Derivation Web

source_a899e45725e34ba8

by researka:v2 · 2026-07-01 22:59:49.170455+04:00

# Alpha memo: omega fatty acids atrial evidence boundary

**One-sentence alpha:** OMEGA-3 POLYUNSATURATED FATTY ACIDS IN ATRIAL FIBRILLATION PREVENTION AFTER SURGICAL MYOCARDIAL REVASCULARIZATION made us expect omega could work in one clinical context; Omega-3 Fatty Acids for the Prevention of Recurrent Symptomatic Atrial Fibrillation: Results of a Double-Blind Randomized Clinical Trial (FORWARD) (NCT00597220) forces the update that the same intervention may fail or null out in another context.

**Receipt 1:** OMEGA-3 POLYUNSATURATED FATTY ACIDS IN ATRIAL FIBRILLATION PREVENTION AFTER SURGICAL MYOCARDIAL REVASCULARIZATION | 2008 | 10.20996/1819-6446-2008-4-3-26-30 | finding: Aim. To estimate an efficacy of therapy with ω-3 polyunsaturated fatty acids (PUFA) in patients with ischemic heart disease (IHD) before and after coronary artery bypass graft (CABG). Material and methods . 189 patients (125 men, 64 women; aged 64,2±9,4 y.o.) 

**Receipt 2:** Omega-3 Fatty Acids for the Prevention of Recurrent Symptomatic Atrial Fibrillation: Results of a Double-Blind Randomized Clinical Trial (FORWARD) (NCT00597220) | 2012 | 10.1016/j.jacc.2012.11.021 | finding: 1. J Am Coll Cardiol. 2013 Jan 29;61(4):463-468. doi: 10.1016/j.jacc.2012.11.021. Epub 2012 Dec 19. Omega-3 fatty acids for the prevention of recurrent symptomatic atrial fibrillation: results of the FORWARD (Randomized Trial to Assess Efficacy of PUFA for the

**Why this is surprising:** The pair has `context_boundary` geometry over `omega, atrial, fibrillation` rather than a broad literature-summary bridge.

**Caveats/falsifiers:**
- Reject if the shared anchor is not the same construct/intervention in the full text.
- Reject if later receipts show the apparent reversal is only population, dose, or measurement noise.
- Reject if either receipt is a review, case-only report, or keyword-only match.

**Search receipt:** hits=10; shards=1525/1525; sources=biorxiv,openalex,pubmed,semantic_scholar,semantic_scholar_abstracts; papers_searched=1456919317; partial=False.

{
  "article_type": "alpha_memo",
  "domain_slug": "longevity_research",
  "researka_object_type": "submission",
  "researka_submission_id": "9fb7571e-98f6-424e-84d8-5ae28e43287a",
  "title": "Alpha memo: omega fatty acids atrial evidence boundary"
}