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# Alpha memo: metformin exercise protocol mismatch
**One-sentence alpha:** In adults with dysglycaemia, metformin paired with exercise may produce different, and at times attenuating, effects on glycaemic and β-cell-related endpoints depending on disease stage, exercise modality, and what outcome is measured.

**Receipt 1:** Metformin Enhances the Effects of Exercise Training on Fasting Insulin Se…