source · application/json
source_afa291d655a24ea2
sha256 9f701dfb7d3b2e8d82ff70570036b9be9f5e3546d93b9029773f7b09eed4c6d9
by researka:v2 · 2026-06-12 16:20:34.991772+04:00
{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "b1750150-b7b0-4272-9e1c-c6eaf8f52abc", "sources": [{"directness": "primary", "doi": "10.1038/s41598-025-32673-9", "risk_of_bias": "not appraised in public sidecar", "study": "Comparative effects of intermittent fasting and calorie restriction on cardiovascular health in adults with overweight or obesity"}, {"directness": "review-level", "doi": "10.3390/nu17121992", "risk_of_bias": "not appraised in public sidecar", "study": "Effects of Intermittent Fasting and Calorie Restriction on Exercise Performance: A Systematic Review and Meta-Analysis"}, {"directness": "review-level", "doi": "10.3390/nu18091450", "risk_of_bias": "not appraised in public sidecar", "study": "Intermittent Fasting and Healthy Aging in Older Adults: A Systematic Review of Cardiometabolic, Mental Health and Cognitive Outcomes with a Network Meta-Analysis of Anthropometric Measures"}, {"directness": "review-level", "doi": "10.1007/s13668-025-00684-7", "risk_of_bias": "not appraised in public sidecar", "study": "Intermittent Fasting for the Prevention of Cardiovascular Disease Risks: Systematic Review and Network Meta-Analysis"}, {"directness": "review-level", "doi": "10.1186/s41043-025-01039-2", "risk_of_bias": "not appraised in public sidecar", "study": "The effect of intermittent fasting on insulin resistance, lipid profile, and inflammation on metabolic syndrome: a GRADE assessed systematic review and meta-analysis"}, {"directness": "review-level", "doi": "10.1007/s13679-025-00645-9", "risk_of_bias": "not appraised in public sidecar", "study": "Additional Effect of Exercise to Intermittent Fasting on Body Composition and Cardiometabolic Health in Adults With Overweight/obesity: A Systematic Review and Meta-analysis"}, {"directness": "review-level", "doi": "10.3389/fnut.2026.1833688", "risk_of_bias": "not appraised in public sidecar", "study": "Intermittent fasting versus continuous energy restriction in MASLD: a systematic review and meta-analysis"}, {"directness": "review-level", "doi": "10.1136/bmj-2024-082007", "risk_of_bias": "not appraised in public sidecar", "study": "Intermittent fasting strategies and their effects on body weight and other cardiometabolic risk factors: systematic review and network meta-analysis of randomised clinical trials"}, {"directness": "review-level", "doi": "10.3390/nu17152436", "risk_of_bias": "not appraised in public sidecar", "study": "Effect of Intermittent Fasting on Anthropometric Measurements, Metabolic Profile, and Hormones in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis"}, {"directness": "review-level", "doi": "10.3389/fnut.2026.1699384", "risk_of_bias": "not appraised in public sidecar", "study": "Effects of intermittent fasting on HbA1c and weight in insulin versus oral hypoglycemic therapy-treated patients with type 2 diabetes mellitus: a systematic review and meta-analysis"}, {"directness": "review-level", "doi": "10.3390/nu17152388", "risk_of_bias": "not appraised in public sidecar", "study": "The Effects of Intermittent Fasting on Inflammatory Markers in Adults: A Systematic Review and Pairwise and Network Meta-Analyses"}, {"directness": "review-level", "doi": "10.1186/s12937-025-01178-6", "risk_of_bias": "not appraised in public sidecar", "study": "The impact of intermittent fasting on body composition and cardiometabolic outcomes in overweight and obese adults: a systematic review and meta-analysis of randomized controlled trials"}, {"directness": "review-level", "doi": "10.7717/peerj.21185", "risk_of_bias": "not appraised in public sidecar", "study": "Intermittent fasting for rheumatic diseases: a systematic review and meta-analysis of conflicting evidence from observational studies and randomized controlled trials"}, {"directness": "primary", "doi": "10.3390/nu17071121", "risk_of_bias": "not appraised in public sidecar", "study": "Influence of Intermittent Fasting on Body Composition, Physical Performance, and the Orexinergic System in Postmenopausal Women: A Pilot Study"}, {"directness": "review-level", "doi": "10.1177/02601060261446178", "risk_of_bias": "not appraised in public sidecar", "study": "Effects of intermittent fasting combined with a ketogenic diet versus a hypocaloric diet on metabolic outcomes in adults with type 2 diabetes mellitus: A controlled clinical study"}, {"directness": "review-level", "doi": "10.64149/j.carcinog.24.10s.2833", "risk_of_bias": "not appraised in public sidecar", "study": "Impact of Intermittent Fasting on Gut Barrier Function and Inflammation"}, {"directness": "primary", "doi": "10.1016/j.numecd.2025.104132", "risk_of_bias": "not appraised in public sidecar", "study": "The impact of intermittent fasting and Mediterranean diet on older adults' physical health and quality of life: A randomized clinical trial."}, {"directness": "review-level", "doi": "10.1136/bmj.c332", "risk_of_bias": "not appraised in public sidecar", "study": "**Schulz 2010.** _Schulz KF, Altman DG, Moher D. CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials. BMJ. 2010;340:c332._ DOI: 10.1136/bmj.c332."}, {"directness": "review-level", "doi": "10.1371/journal.pmed.0020124", "risk_of_bias": "not appraised in public sidecar", "study": "**Ioannidis 2005.** _Ioannidis JPA. Why most published research findings are false. PLoS Med. 2005;2(8):e124._ DOI: 10.1371/journal.pmed.0020124. PMID: 16060722."}, {"directness": "review-level", "doi": "10.2337/dc24-s006", "risk_of_bias": "not appraised in public sidecar", "study": "**ADA 2024.** _American Diabetes Association. Standards of Care in Diabetes. Diabetes Care. 2024;47(Suppl 1)._ DOI: 10.2337/dc24-S006."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen."}]}
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}