Derivation Web

source_b069b3f75d214d68

by researka:v2 · 2026-06-27 10:16:23.682448+04:00

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
The effect of rapamycin and its analogues on age-related musculoskeletal diseases: a systematic review,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Safety Evaluations of Rapamycin Perfluorocarbon Nanoparticles in Ovarian Tumor-Bearing Mice,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
DESTINY-Breast08: A Phase Ib Study of Trastuzumab Deruxtecan in Combination with Other Anticancer Therapies in Patients with HER2-Low Metastatic Breast Cancer,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Anti-Mullerian hormone attenuates both cyclophosphamide-induced damage and PI3K signalling activation, while rapamycin attenuates only PI3K signalling activation, in human ovarian cortex in vitro",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Rapamycin-resistant polyclonal Th1/Tc1 cell therapy (RAPA-201) safely induces disease remissions in relapsed, refractory multiple myeloma",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Systematic review: The gut microbiota as a link between colorectal cancer and obesity,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
mTOR inhibition modulates vaccine-induced immune responses to generate memory T cells in patients with solid tumors,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"TCTP protein degradation by targeting mTORC1 and signaling through S6K, Akt, and Plk1 sensitizes lung cancer cells to DNA-damaging drugs",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Physical Activity and Hepatocellular Carcinoma Outcomes: a Narrative Review of Pre-clinical, Observational, and Interventional Evidence",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
KNSTRN knockdown impairs autophagy flux to inhibit bladder cancer progression,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The novel tertiary amine LSD1 inhibitor 596 inhibits endometrial cancer through the mTOR signal transduction pathway,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Zanidatamab, a Dual HER2-Targeted Bispecific Antibody, in Patients with Unresectable Locally Advanced or Metastatic HER2-Positive Salivary Gland Cancer: A Combined Analysis of Early-Phase Studies",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Targeted Delivery of Rapamycin via Epidermal Growth Factor Receptors in Pancreatic Cancer Cells Inhibits Cell Proliferation and Induces Apoptosis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"A network meta-analysis of efficacy and safety for first-line and second/further-line therapies in postmenopausal women with hormone receptor-positive, HER2-negative, advanced breast cancer",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Rapamycin Antagonizes BCRP-Mediated Drug Resistance Through the PI3K/Akt/mTOR Signaling Pathway in mPRα-Positive Breast Cancer,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
BEX2 regulates autophagy by inhibiting PIK3CA-p85 interaction in non-small-cell lung cancer cells,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Human recombinant arginase I [HuArgI (Co)-PEG5000]-induced arginine depletion inhibits ovarian cancer cell adhesion and migration through autophagy-mediated inhibition of RhoA,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Depletion of intrinsic expression of Interleukin-8 in prostate cancer cells causes cell cycle arrest, spontaneous apoptosis and increases the efficacy of chemotherapeutic drugs",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Rapamycin potentiates cytotoxicity by docetaxel possibly through downregulation of Survivin in lung cancer cells,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Ioannidis 2005,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation

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