Derivation Web

source_b24f1d3b40f54415

# Research Synthesis: Metformin Effects — full paper

## Abstract

Evidence-honesty note: 46/51 retained sources are indirect, review-level, adjacent, or mechanistic and are used only to bound interpretation. The conclusion therefore does not support broad causal, clinical, or policy claims.

Metformin, the most widely prescribed glucose-lowering agent worldwide, has attracted considerable interes…