Derivation Web

source_b36a457f65d24a72

by researka:v2 · 2026-06-21 23:11:13.566752+04:00

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Association of serum Klotho and fibroblast growth factor-23 levels with vascular calcification severity in patients with chronic kidney disease: an observational cohort study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Effects of acute, subacute, and chronic exercise on plasma s-Klotho levels: a systematic review and meta-analysis",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Role of klotho and fibroblast growth factor 23 in arterial calcification, thickness, and stiffness: a meta-analysis of observational studies",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Soluble Klotho, a biomarker and therapeutic strategy to reduce bronchopulmonary dysplasia and pulmonary hypertension in preterm infants",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Circulating α-Klotho and Multidimensional Aging and Frailty Outcomes: A Systematic Review and Meta-Analysis from the European Renal Association CKD-MBD Working Group,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Associations Between Klotho/FGF-Related Protein Expression in Peripheral Blood Mononuclear Cells, Inflammation, and Muscle Function in Middle-Aged Adults with Obesity: A Pilot Study",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Influence of Klotho Protein Levels in Obesity and Sarcopenia: A Systematic Review,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Interaction Effect of Estimated Pulse Wave Velocity and Serum Klotho Level on Chronic Kidney Disease,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
α -Klotho: An Early Risk-Predictive Biomarker for Acute Kidney Injury in Patients with Acute Myocardial Infarction,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
α -klotho as a biomarker of amyloid β levels in the cerebrospinal fluid,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Low serum klotho concentration is associated with worse cognition, psychological components of frailty, dependence, and falls in nursing home residents",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Association between serum α-Klotho levels and tinnitus stratified by sex and depression: A cross-sectional study from NHANES,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"High-Intensity Interval and Aerobic Training Alleviate Cardiac Pathology, Apoptosis, and Atrial Fibrillation in Rats with Chronic Kidney Disease: The Roles of FGF23 and Klotho",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Association of magnesium depletion score with serum anti-aging protein Klotho in the middle-aged and older populations,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Interplay Between Fibroblast Growth Factor-19, Beta-Klotho, and Receptors Impacts Cardiovascular Risk in Chronic Kidney Disease",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Role of soluble alpha-klotho as a novel biomarker for characterizing children with autism spectrum disorder in Kurdistan, Iraq",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Anti-aging protein α-Klotho is potential for reducing comorbidity risk of cardiometabolic diseases in vulnerable populations and enhancing long-term prognosis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Serum klotho is inversely associated with girth in older women but is not associated with falls or musculoskeletal measures in either sex,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
A systematic review and meta-analysis demonstrating Klotho as an emerging exerkine,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Sex differences in the association between Life’s Essential 8 and serum anti-aging Klotho protein levels: a cross-sectional analysis in middle-aged to older adults,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Associations of KLOTHO-VS heterozygosity and α-Klotho protein with cerebrospinal fluid Alzheimer's disease biomarkers,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Circulating Klotho and mortality patterns among US cancer survivors: A cohort study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Modulation of PKCα/ETS1 by klotho restores CYB5R4-dependent mitochondrial function in proximal tubular epithelial cells to attenuate the progression of diabetic kidney disease,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Sex differences between atherogenic index of plasma and α-klotho levels in middle-aged and older adults: NHANES 2007–2016,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Beneficial effects of physical exercise on the osteo-renal Klotho-FGF-23 axis in Chronic Kidney Disease: A systematic review with meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Examining Insulin Resistance and BMI in the Context of Alpha-Klotho and Functional Decline,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Correlation between soluble klotho and chronic kidney disease–mineral and bone disorder in chronic kidney disease: a meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Correlation Between Soluble Klotho and Vascular Calcification in Chronic Kidney Disease: A Meta-Analysis and Systematic Review,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Association of Increased Cardio-Ankle Vascular Index (CAVI) with Echocardiographically Impaired Diastolic Dysfunction and Low Klotho Levels in Kidney Transplant Patients,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Risk factors for developing osteoporosis in diabetic kidney disease and its correlation with calcium-phosphorus metabolism, FGF23, and Klotho",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Serum cystatin C, kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, klotho and fibroblast growth factor-23 in the early prediction of acute kidney injury associated with sepsis in a Chinese emergency cohort study",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Low levels of circulating anti-ageing hormone Klotho predict the onset and progression of diabetic retinopathy,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Central adiposity and α-klotho: inflammatory mechanisms underlying aging biomarkers related to body roundness index,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Relationship of Soluble Klotho and Early Stage of Diabetic Nephropathy: A Systematic Review and Meta-Analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Klotho and Clinical Outcomes in CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Preeclampsia as a Study Model for Aging: The Klotho Gene Paradigm,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Sodium-glucose co-transporter-2 inhibitors increase Klotho in patients with diabetic kidney disease: A clinical and experimental study.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Abstract 4365476: The Klotho Protein Reduces Vascular Calcification via Suppressing GPX4-mediated Ferroptosis in Vascular Smooth Muscle Cells,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
The Anti-Inflammatory Actions of Soluble Klotho in Brain Aging and Its Main Associated Diseases,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Lower circulating soluble Klotho level is associated with increased risk of all-cause mortality in chronic kidney disease patients: a systematic review and meta-analysis.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Paradoxical prognostic role of alpha-klotho protein: a marker of increased mortality risk in the post-myocardial infarction setting,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Age-related alterations in plasma biomarkers of relevance to Alzheimer's disease are attenuated in KLOTHO KL-VS heterozygotes,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Association between serum Klotho and thrombocytopenia in middle-aged and older adults: A cross-sectional study based on NHANES.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Serum klotho is inversely associated with metabolic syndrome in chronic kidney disease: results from the KNOW-CKD study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Influence of exogenous growth hormone administration on circulating concentrations of α-klotho in healthy and chronic kidney disease subjects: a prospective, single-center open case-control pilot study",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The FGF23–Klotho axis and cardiac tissue Doppler imaging in pediatric chronic kidney disease—a prospective cohort study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Correlation between Soluble α -Klotho and Renal Function in Patients with Chronic Kidney Disease: A Review and Meta-Analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Prognostic Value and Link to Atrial Fibrillation of Soluble Klotho and FGF23 in Hemodialysis Patients,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The Prognostic Role of Klotho in Patients with Chronic Kidney Disease: A Systematic Review and Meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
The association between soluble klotho and cardiovascular parameters in chronic kidney disease: results from the KNOW-CKD study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Expression of Longevity Genes Induced by a Low-Dose Fluvastatin and Valsartan Combination with the Potential to Prevent/Treat “Aging-Related Disorders”,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"The effect of nephrectomy on Klotho, FGF-23 and bone metabolism",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Studenski 2011,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Cesari 2009,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Perera 2006,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Bohannon 1997,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Cruz-Jentoft 2019,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Anisimov 2008,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Tinetti 1988,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Ioannidis 2005,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation

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