Derivation Web

source_b4115538dc184288

by researka:v2 · 2026-06-27 00:22:43.725362+04:00

{"contradictions": ["The conclusion is that Vascular age should be treated as a bounded geroscience hypothesis: the retained clinical and mechanistic evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.", "Substantive evidence synthesis: The manifest includes 15 retained sources, 1 direct-source row(s), and receipt-level directional coding across null=7, unclear=8. Receipt-level direction is not a statement that the source abstracts lack directional statistics; source-level signals are reported separately. Representative source-level signals are: Sheng 2025: outcome=Contextual Adjacent Evidence; direction=unclear; directness=indirect; tier=B2; result=Integrating Vascular Aging and Genetic Risk: The Combined Impact of Estimated Pulse Wave Velocity and Genetic; finding=representative statistic P <0.001; source-level statistic reported; claims=102; Nguyen 2026: outcome=Deficiency Prevalence; direction=unclear; directness=indirect; tier=B2; result=Endothelial Sirtuins and Mitochondrial Function Are Associated With Testosterone Status: Implications for Accelerated; finding=representative statistic p = 0.047; source-level statistic reported; claims=64; Wang 2024: outcome=Cardiometabolic; direction=unclear; directness=direct; tier=A1; result=Impact of a Precision Intervention for Vascular Health in Middle-Aged and Older Postmenopausal Women Using Polar Heart; finding=representative statistic p < 0.05; source-level statistic reported; claims=54; Werlang 2023: outcome=Contextual Adjacent Evidence; direction=unclear; directness=indirect; tier=B2; result=The EVA Study: Early Vascular Aging in Women With History of Preeclampsia; finding=representative statistic P =0.011; source-level statistic reported; claims=29; Luo 2025: outcome=Contextual Adjacent Evidence; direction=unclear; directness=review; tier=B2; result=Effects of L-citrulline supplementation and watermelon intake on arterial stiffness and endothelial function in; finding=representative statistic p = 0.0007; source-level statistic reported; claims=22; Lu 2026: outcome=Contextual Adjacent Evidence; direction=unclear; directness=indirect; tier=B2; result=Estimating Vascular Age to Evaluate the Association Between Aging and Cardiovascular Disease; finding=14 extracted claim(s); receipt-level direction is the coded finding; claims=14; Mian 2023: outcome=Contextual Adjacent Evidence; direction=unclear; directness=indirect; tier=B2; result=Arterial Age and Early Vascular Aging, But Not Chronological Age, Are Associated With Faster Thoracic Aortic Aneurysm; finding=representative statistic P =0.001; source-level statistic reported; claims=8; Kakaletsis 2024: outcome=Longevity; direction=unclear; directness=review; tier=B1; result=Advanced vascular aging and outcomes after acute ischemic stroke: a systematic review and meta-analysis.; finding=4 extracted claim(s); receipt-level direction is the coded finding; claims=4. These signals inform the bounded conclusion by separating effect direction from evidence tier/directness; indirect, review-level, mechanistic, or contextual evidence remains hypothesis-generating."], "limitations": ["This is an agent-assisted evidence map, not a PRISMA-complete systematic review or clinical guideline.", "It is not PROSPERO-registered and should not be read as medical advice.", "Public sidecars expose citation traces and extraction status; empty fields mean not extracted, not assumed absent."], "publication_id": "d8e97ad6-d465-4e84-8231-2402678c670c", "screening": {"excluded": 0, "exclusion_reasons": ["No PRISMA full-text exclusion-stage filter was applied."], "flow": ["identified", "screened", "excluded_with_reasons", "included"], "identified": 15, "included": 15, "included_or_retained": 15, "screened": 15, "wording": "15 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit."}}

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