Derivation Web

source_b6a6fa612c6d4f51

by researka:v2 · 2026-06-05 16:07:30.659849+04:00

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "fa3d00ab-72a0-4cb6-aaa0-48b50e0f9875", "sources": [{"directness": "primary", "doi": "10.1038/s41598-026-37044-6", "risk_of_bias": "not appraised in public sidecar", "study": "Potential biomarkers for early periodontal inflammation: investigating CD5 + B cells, salivary cytokines and oral microbiome"}, {"directness": "primary", "doi": "10.1038/s41522-024-00476-x", "risk_of_bias": "not appraised in public sidecar", "study": "Nisin lantibiotic prevents NAFLD liver steatosis and mitochondrial oxidative stress following periodontal disease by abrogating oral, gut and liver dysbiosis"}, {"directness": "primary", "doi": "10.1111/jre.70046", "risk_of_bias": "not appraised in public sidecar", "study": "Oral Microbiome Signatures in Periodontitis and Edentulism—A Population‐Based Study"}, {"directness": "primary", "doi": "10.3390/ani13223544", "risk_of_bias": "not appraised in public sidecar", "study": "The Oral Microbiome across Oral Sites in Cats with Chronic Gingivostomatitis, Periodontal Disease, and Tooth Resorption Compared with Healthy Cats"}, {"directness": "primary", "doi": "10.1111/jcpe.14201", "risk_of_bias": "not appraised in public sidecar", "study": "Non‐Surgical Periodontal Therapy Modulates Oral Microbiome in Primary Immunodeficient Children"}, {"directness": "primary", "doi": "10.1111/jre.70055", "risk_of_bias": "not appraised in public sidecar", "study": "Multi‐Omics Signatures of Periodontitis and Periodontal Therapy on the Oral and Gut Microbiome"}, {"directness": "primary", "doi": "10.1038/s41598-025-91105-w", "risk_of_bias": "not appraised in public sidecar", "study": "Involvement of propionate, citrulline, homoserine, and succinate in oral microbiome metabolite-driven periodontal disease progression"}, {"directness": "primary", "doi": "10.3390/ijms22115876", "risk_of_bias": "not appraised in public sidecar", "study": "Oral Microbiome in Relation to Periodontitis Severity and Systemic Inflammation"}, {"directness": "primary", "doi": "10.3390/ani15131834", "risk_of_bias": "not appraised in public sidecar", "study": "The Oral Microbiome in Queensland Free-Ranging Koalas ( Phascolarctos cinereus ) and Its Association with Age and Periodontal Disease"}, {"directness": "primary", "doi": "10.1128/msystems.00683-23", "risk_of_bias": "not appraised in public sidecar", "study": "Dysbiosis of oral microbiome persists after dental treatment-induced remission of periodontal disease and dental caries"}, {"directness": "primary", "doi": "10.1038/s44400-025-00004-4", "risk_of_bias": "not appraised in public sidecar", "study": "Oral microbiome brain axis and cognitive performance in older adults"}, {"directness": "primary", "doi": "10.1002/alz70856_103436", "risk_of_bias": "not appraised in public sidecar", "study": "Association between Periodontal Disease and Alzheimer's Disease Risk Factors: A Longitudinal Oral Microbiome Study"}, {"directness": "primary", "doi": "10.3390/microorganisms13112573", "risk_of_bias": "not appraised in public sidecar", "study": "Neutrophils at the Crossroads of Oral Microbiome Dysbiosis and Periodontal Disease"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen."}]}

{
  "researka_object_type": "publication_sidecar",
  "researka_publication_id": "fa3d00ab-72a0-4cb6-aaa0-48b50e0f9875",
  "researka_submission_id": "052c76e8-8313-4963-94ee-df7cea793bc3",
  "sidecar_name": "risk_of_bias.json",
  "sidecar_url": "https://api.researka.org/publications/fa3d00ab-72a0-4cb6-aaa0-48b50e0f9875/sidecars/risk_of_bias.json"
}