Derivation Web

source_b861ca5d7944420a

by researka:v2 · 2026-06-23 08:26:01.428382+04:00

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
"Immunogenicity and safety of quadrivalent influenza vaccine among young and older adults in Tianjin, China: implication of immunosenescence as a risk factor",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Kaempferol alleviates T-cell immunosenescence and inflammaging in aged mice via the SIRT3-LKB1-AMPK-mitophagy pathway,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
BC02-adjuvanted varicella-zoster virus glycoprotein E subunit vaccine overcomes immunosenescence to induce robust neutralizing antibodies and multifunctional T-cell immunity in seropositive aged murine models,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Physical activity decreases cancer burden by alleviating immunosenescence-related inflammation and improving overall immunity,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Predictors of Severe Herpes Zoster: Contributions of Immunosenescence, Metabolic Risk, and Lifestyle Behaviors",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Biological age and immunosenescence in Colombian centenarians,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Immunosenescence Profile Is Associated With Increased Susceptibility to Severe COVID ‐19,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Fasting and calorie restriction modulate age‐associated immunosenescence and inflammaging,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The impact of growth hormone (GH) on immunosenescence: exploring the role of B and T cells,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Preliminary Data on the Senolytic Effects of Agrimonia pilosa Ledeb. Extract Containing Agrimols for Immunosenescence in Middle-Aged Humans: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparison Study",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
CD31 + naïve T cells associate with immunosenescence and responsiveness to multiple vaccines in older adults,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Co-administration of vitamin D and N-acetylcysteine to modulate immunosenescence in older adults with vitamin D deficiency: a randomized clinical trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Age-related changes in circulating immune factors reveal biomarkers of immunosenescence,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Living in endemic area for infectious diseases is associated to differences in immunosenescence and inflammatory signatures,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Differential associations of anti-cytomegalovirus antibodies and soluble CD14 levels with immunosenescence in people living with HIV on long term antiretroviral therapy,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Immunosenescence and cytomegalovirus-associated immune signatures on severe acute respiratory syndrome coronavirus 2 booster responses,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
MAM‐STAT3‐Driven Mitochondrial Ca +2 Upregulation Contributes to Immunosenescence in Type A Mandibuloacral Dysplasia Patients,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Enhancing flu vaccine responses in older adults: preliminary insights from the ISOLDA study on immunosenescence and antioxidant and anti-inflammatory approaches,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Lymphocyte-To-Monocyte Ratio is Partially Mediated in Age-Related Cardiovascular Mortality in HFpEF: Immunosenescence, Inflamm-Aging, and Longevity",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Aging, inflammaging and immunosenescence as risk factors of severe COVID-19",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Immunosenescence and its impact on ischemic stroke risk and outcomes in older adults: a systematic review,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
A randomized controlled trial to assess the efficacy of standardized tai chi in prefrail older adults with immunosenescence: design and protocol,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Disease Aggravation With Age in an Experimental Model of Multiple Sclerosis: Role of Immunosenescence,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Deciphering Immunosenescence From Child to Frailty: Transcriptional Changes, Inflammation Dynamics, and Adaptive Immune Alterations",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The pathophysiological mechanisms of immunosenescence in coronary artery disease,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Immunosenescence is a therapeutic target for frailty in older adults: a narrative review,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Immunosenescence and Vaccine Efficacy in Aging: Dynamic Interplay of Gut Microbiota and mTOR Signaling Pathways,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Aging-associated transcriptional programs in T cells signify constituents of TGF-β signaling for immunosenescence,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Markers of Type 2 Inflammation and Immunosenescence Are Upregulated in Localized Scleroderma,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Gene Expression Changes as Biomarkers of Immunosenescence in Bulgarian Individuals of Active Age,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Age Versus Immunity: Dietary Influences on Immunosenescence,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
HIV infection and immunosenescence: challenges and intervention strategies,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Bridging aging and colorectal cancer: synergistic roles of inflammaging and immunosenescence,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Red ginseng extract enhances mitochondrial function and alleviates immunosenescence in T cells,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Immunosenescence: How Aging Increases Susceptibility to Bacterial Infections and Virulence Factors,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"The 3 I’s of immunity and aging: immunosenescence, inflammaging, and immune resilience",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Immunosenescence and Allergy: Molecular and Cellular Links Between Inflammaging, Neuro-Immune Aging, and Response to Biologic Therapies",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Immunosenescence and susceptibility to respiratory viruses: a state-of-the-art review,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Multivariate analysis of immunosenescence data in healthy humans and diverse diseases,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Nanoparticle-mediated delivery of herbal-derived natural products to modulate immunosenescence-induced drug resistance in cancer therapy: a comprehensive review,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Rheumatoid Arthritis and Osteoporosis as Prototypes of Immunosenescence in Osteoimmunology: Molecular Pathways of Inflammaging and Targeted Therapies,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Insights into tumor vaccines for elderly individuals in the context of immunosenescence,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Inflammaging and Immunosenescence in the Post‐COVID Era: Small Molecules, Big Challenges",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
“Immunopause” no more: exercise to counter immunosenescence in aging,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Impact and potential value of immunosenescence on solid gastrointestinal tumors,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"The role of autoantibodies in bridging obesity, aging, and immunosenescence",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Ioannidis 2005,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation

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