Derivation Web

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by researka:v2 · 2026-06-25 08:52:23.337826+04:00

{"publication_id": "49395fbb-d4a2-4334-b9a8-44b8df0e7129", "traces": [{"candidate_sources": [{"doi": "10.1161/jaha.122.027824", "study": "Sodium‐Glucose Cotransporter‐2 Inhibitors After Acute Myocardial Infarction in Patients With Type 2 Diabetes: A Population‐Based Investigation", "url": "https://doi.org/10.1161/jaha.122.027824"}, {"doi": "10.1186/s12933-022-01455-2", "study": "Efficacy and safety of sodium-glucose cotransporter 2 inhibitors initiation in patients with acute heart failure, with and without type 2 diabetes: a systematic review and meta-analysis", "url": "https://doi.org/10.1186/s12933-022-01455-2"}, {"doi": "10.1161/jaha.120.019463", "study": "Effects of Sodium/Glucose Cotransporter 2 (SGLT2) Inhibitors on Cardiovascular and Metabolic Outcomes in Patients Without Diabetes Mellitus: A Systematic Review and Meta‐Analysis of Randomized‐Controlled Trials", "url": "https://doi.org/10.1161/jaha.120.019463"}, {"doi": "10.1016/j.phrs.2021.105836", "study": "SGLT-2 inhibitors reduce the risk of cerebrovascular/cardiovascular outcomes and mortality: A systematic review and meta-analysis of retrospective cohort studies", "url": "https://doi.org/10.1016/j.phrs.2021.105836"}, {"doi": "10.1093/eurjpc/zwab173", "study": "Effect of sodium-glucose cotransporter-2 inhibitors on cardiac remodelling: a systematic review and meta-analysis", "url": "https://doi.org/10.1093/eurjpc/zwab173"}], "claim": "Across retrieved fact-level receipts for SGLT2 inhibitors, which endpoints show directionally favorable versus null/non-convergent signals, and what matched PICO remains untested?", "claim_id": "claim_1"}, {"candidate_sources": [{"doi": "10.1161/jaha.122.027824", "study": "Sodium‐Glucose Cotransporter‐2 Inhibitors After Acute Myocardial Infarction in Patients With Type 2 Diabetes: A Population‐Based Investigation", "url": "https://doi.org/10.1161/jaha.122.027824"}, {"doi": "10.1186/s12933-022-01455-2", "study": "Efficacy and safety of sodium-glucose cotransporter 2 inhibitors initiation in patients with acute heart failure, with and without type 2 diabetes: a systematic review and meta-analysis", "url": "https://doi.org/10.1186/s12933-022-01455-2"}, {"doi": "10.1161/jaha.120.019463", "study": "Effects of Sodium/Glucose Cotransporter 2 (SGLT2) Inhibitors on Cardiovascular and Metabolic Outcomes in Patients Without Diabetes Mellitus: A Systematic Review and Meta‐Analysis of Randomized‐Controlled Trials", "url": "https://doi.org/10.1161/jaha.120.019463"}, {"doi": "10.1016/j.phrs.2021.105836", "study": "SGLT-2 inhibitors reduce the risk of cerebrovascular/cardiovascular outcomes and mortality: A systematic review and meta-analysis of retrospective cohort studies", "url": "https://doi.org/10.1016/j.phrs.2021.105836"}, {"doi": "10.1093/eurjpc/zwab173", "study": "Effect of sodium-glucose cotransporter-2 inhibitors on cardiac remodelling: a systematic review and meta-analysis", "url": "https://doi.org/10.1093/eurjpc/zwab173"}], "claim": "Finding: the early use of SGLT2 inhibitors was associated with lower risks of the primary end point (HR 0.68 [95% CI, 0.54-0.87]; P=0.002)", "claim_id": "claim_2"}, {"candidate_sources": [{"doi": "10.1161/jaha.122.027824", "study": "Sodium‐Glucose Cotransporter‐2 Inhibitors After Acute Myocardial Infarction in Patients With Type 2 Diabetes: A Population‐Based Investigation", "url": "https://doi.org/10.1161/jaha.122.027824"}, {"doi": "10.1186/s12933-022-01455-2", "study": "Efficacy and safety of sodium-glucose cotransporter 2 inhibitors initiation in patients with acute heart failure, with and without type 2 diabetes: a systematic review and meta-analysis", "url": "https://doi.org/10.1186/s12933-022-01455-2"}, {"doi": "10.1161/jaha.120.019463", "study": "Effects of Sodium/Glucose Cotransporter 2 (SGLT2) Inhibitors on Cardiovascular and Metabolic Outcomes in Patients Without Diabetes Mellitus: A Systematic Review and Meta‐Analysis of Randomized‐Controlled Trials", "url": "https://doi.org/10.1161/jaha.120.019463"}, {"doi": "10.1016/j.phrs.2021.105836", "study": "SGLT-2 inhibitors reduce the risk of cerebrovascular/cardiovascular outcomes and mortality: A systematic review and meta-analysis of retrospective cohort studies", "url": "https://doi.org/10.1016/j.phrs.2021.105836"}, {"doi": "10.1093/eurjpc/zwab173", "study": "Effect of sodium-glucose cotransporter-2 inhibitors on cardiac remodelling: a systematic review and meta-analysis", "url": "https://doi.org/10.1093/eurjpc/zwab173"}], "claim": "Finding: Initiation of SGLT2 inhibitors in patients with AHF reduced the risk of rehospitalization for heart failure (OR 0.52; 95% CI [0.42, 0.65])", "claim_id": "claim_3"}, {"candidate_sources": [{"doi": "10.1161/jaha.122.027824", "study": "Sodium‐Glucose Cotransporter‐2 Inhibitors After Acute Myocardial Infarction in Patients With Type 2 Diabetes: A Population‐Based Investigation", "url": "https://doi.org/10.1161/jaha.122.027824"}, {"doi": "10.1186/s12933-022-01455-2", "study": "Efficacy and safety of sodium-glucose cotransporter 2 inhibitors initiation in patients with acute heart failure, with and without type 2 diabetes: a systematic review and meta-analysis", "url": "https://doi.org/10.1186/s12933-022-01455-2"}, {"doi": "10.1161/jaha.120.019463", "study": "Effects of Sodium/Glucose Cotransporter 2 (SGLT2) Inhibitors on Cardiovascular and Metabolic Outcomes in Patients Without Diabetes Mellitus: A Systematic Review and Meta‐Analysis of Randomized‐Controlled Trials", "url": "https://doi.org/10.1161/jaha.120.019463"}, {"doi": "10.1016/j.phrs.2021.105836", "study": "SGLT-2 inhibitors reduce the risk of cerebrovascular/cardiovascular outcomes and mortality: A systematic review and meta-analysis of retrospective cohort studies", "url": "https://doi.org/10.1016/j.phrs.2021.105836"}, {"doi": "10.1093/eurjpc/zwab173", "study": "Effect of sodium-glucose cotransporter-2 inhibitors on cardiac remodelling: a systematic review and meta-analysis", "url": "https://doi.org/10.1093/eurjpc/zwab173"}], "claim": "Finding: those with heart failure treated with SGLT2 inhibitors had a 20% relative risk reduction in cardiovascular deaths and heart failure hospitalizations (risk ratio, 0.78; P<0.001).", "claim_id": "claim_4"}, {"candidate_sources": [{"doi": "10.1161/jaha.122.027824", "study": "Sodium‐Glucose Cotransporter‐2 Inhibitors After Acute Myocardial Infarction in Patients With Type 2 Diabetes: A Population‐Based Investigation", "url": "https://doi.org/10.1161/jaha.122.027824"}, {"doi": "10.1186/s12933-022-01455-2", "study": "Efficacy and safety of sodium-glucose cotransporter 2 inhibitors initiation in patients with acute heart failure, with and without type 2 diabetes: a systematic review and meta-analysis", "url": "https://doi.org/10.1186/s12933-022-01455-2"}, {"doi": "10.1161/jaha.120.019463", "study": "Effects of Sodium/Glucose Cotransporter 2 (SGLT2) Inhibitors on Cardiovascular and Metabolic Outcomes in Patients Without Diabetes Mellitus: A Systematic Review and Meta‐Analysis of Randomized‐Controlled Trials", "url": "https://doi.org/10.1161/jaha.120.019463"}, {"doi": "10.1016/j.phrs.2021.105836", "study": "SGLT-2 inhibitors reduce the risk of cerebrovascular/cardiovascular outcomes and mortality: A systematic review and meta-analysis of retrospective cohort studies", "url": "https://doi.org/10.1016/j.phrs.2021.105836"}, {"doi": "10.1093/eurjpc/zwab173", "study": "Effect of sodium-glucose cotransporter-2 inhibitors on cardiac remodelling: a systematic review and meta-analysis", "url": "https://doi.org/10.1093/eurjpc/zwab173"}], "claim": "SGLT-2 inhibitors reduce the risk of cerebrovascular/cardiovascular outcomes and mortality: A systematic review and meta-analysis of retrospective cohort studies [review; 2021] doi:10.1016/j.phrs.2021.105836", "claim_id": "claim_5"}, {"candidate_sources": [{"doi": "10.1161/jaha.122.027824", "study": "Sodium‐Glucose Cotransporter‐2 Inhibitors After Acute Myocardial Infarction in Patients With Type 2 Diabetes: A Population‐Based Investigation", "url": "https://doi.org/10.1161/jaha.122.027824"}, {"doi": "10.1186/s12933-022-01455-2", "study": "Efficacy and safety of sodium-glucose cotransporter 2 inhibitors initiation in patients with acute heart failure, with and without type 2 diabetes: a systematic review and meta-analysis", "url": "https://doi.org/10.1186/s12933-022-01455-2"}, {"doi": "10.1161/jaha.120.019463", "study": "Effects of Sodium/Glucose Cotransporter 2 (SGLT2) Inhibitors on Cardiovascular and Metabolic Outcomes in Patients Without Diabetes Mellitus: A Systematic Review and Meta‐Analysis of Randomized‐Controlled Trials", "url": "https://doi.org/10.1161/jaha.120.019463"}, {"doi": "10.1016/j.phrs.2021.105836", "study": "SGLT-2 inhibitors reduce the risk of cerebrovascular/cardiovascular outcomes and mortality: A systematic review and meta-analysis of retrospective cohort studies", "url": "https://doi.org/10.1016/j.phrs.2021.105836"}, {"doi": "10.1093/eurjpc/zwab173", "study": "Effect of sodium-glucose cotransporter-2 inhibitors on cardiac remodelling: a systematic review and meta-analysis", "url": "https://doi.org/10.1093/eurjpc/zwab173"}], "claim": "Finding: reduced risk of stroke with SGLT2 inhibitors compared to DPP-4 inhibitors (Hazard ratio HR, 0.89; 95%CI, 0.82-0.96)", "claim_id": "claim_6"}, {"candidate_sources": [{"doi": "10.1161/jaha.122.027824", "study": "Sodium‐Glucose Cotransporter‐2 Inhibitors After Acute Myocardial Infarction in Patients With Type 2 Diabetes: A Population‐Based Investigation", "url": "https://doi.org/10.1161/jaha.122.027824"}, {"doi": "10.1186/s12933-022-01455-2", "study": "Efficacy and safety of sodium-glucose cotransporter 2 inhibitors initiation in patients with acute heart failure, with and without type 2 diabetes: a systematic review and meta-analysis", "url": "https://doi.org/10.1186/s12933-022-01455-2"}, {"doi": "10.1161/jaha.120.019463", "study": "Effects of Sodium/Glucose Cotransporter 2 (SGLT2) Inhibitors on Cardiovascular and Metabolic Outcomes in Patients Without Diabetes Mellitus: A Systematic Review and Meta‐Analysis of Randomized‐Controlled Trials", "url": "https://doi.org/10.1161/jaha.120.019463"}, {"doi": "10.1016/j.phrs.2021.105836", "study": "SGLT-2 inhibitors reduce the risk of cerebrovascular/cardiovascular outcomes and mortality: A systematic review and meta-analysis of retrospective cohort studies", "url": "https://doi.org/10.1016/j.phrs.2021.105836"}, {"doi": "10.1093/eurjpc/zwab173", "study": "Effect of sodium-glucose cotransporter-2 inhibitors on cardiac remodelling: a systematic review and meta-analysis", "url": "https://doi.org/10.1093/eurjpc/zwab173"}], "claim": "This receipt-backed scoping note has one bounded signal: SGLT2 inhibitors shows directionally consistent signals across heterogeneous contexts across this 5-source primary/review bundle (2021-2023). Grouped by direction: directionally favorable: 5 receipt(s). The source facts cover 5 population context(s) and 4 intervention/exposure context(s), so this is a scoping signal about where endpoints diverge, without establishing a causal, clinical, species-translated, or mechanistically integrated claim. Direction is homogeneous: all selected receipts are directionally favorable. The boundary is population, comparator, and endpoint diversity, not directional disagreement. The listed effect sizes remain source-specific across endpoints and populations; they are not pooled or averaged. This is a heterogeneous indication/context map, not a unified disease-specific or endpoint-family claim. Concrete source-level examples: the early use of SGLT2 inhibitors was associated with lower risks of the primary end point (HR 0.68 [95% CI, 0.54-0.87]; P=0.002); Initiation of SGLT2 inhibitors in patients with AHF reduced the risk of rehospitalization for heart failure (OR 0.52; 95% CI [0.42, 0.65]); those with heart failure treated with SGLT2 inhibitors had a 20% relative risk reduction in cardiovascular deaths and heart failure hospitalizations (risk ratio, 0.78....", "claim_id": "claim_7"}, {"candidate_sources": [{"doi": "10.1161/jaha.122.027824", "study": "Sodium‐Glucose Cotransporter‐2 Inhibitors After Acute Myocardial Infarction in Patients With Type 2 Diabetes: A Population‐Based Investigation", "url": "https://doi.org/10.1161/jaha.122.027824"}, {"doi": "10.1186/s12933-022-01455-2", "study": "Efficacy and safety of sodium-glucose cotransporter 2 inhibitors initiation in patients with acute heart failure, with and without type 2 diabetes: a systematic review and meta-analysis", "url": "https://doi.org/10.1186/s12933-022-01455-2"}, {"doi": "10.1161/jaha.120.019463", "study": "Effects of Sodium/Glucose Cotransporter 2 (SGLT2) Inhibitors on Cardiovascular and Metabolic Outcomes in Patients Without Diabetes Mellitus: A Systematic Review and Meta‐Analysis of Randomized‐Controlled Trials", "url": "https://doi.org/10.1161/jaha.120.019463"}, {"doi": "10.1016/j.phrs.2021.105836", "study": "SGLT-2 inhibitors reduce the risk of cerebrovascular/cardiovascular outcomes and mortality: A systematic review and meta-analysis of retrospective cohort studies", "url": "https://doi.org/10.1016/j.phrs.2021.105836"}, {"doi": "10.1093/eurjpc/zwab173", "study": "Effect of sodium-glucose cotransporter-2 inhibitors on cardiac remodelling: a systematic review and meta-analysis", "url": "https://doi.org/10.1093/eurjpc/zwab173"}], "claim": "null/non-convergent or other/mixed: the extracted fact is null, mixed, or not directionally interpretable.", "claim_id": "claim_8"}, {"candidate_sources": [{"doi": "10.1161/jaha.122.027824", "study": "Sodium‐Glucose Cotransporter‐2 Inhibitors After Acute Myocardial Infarction in Patients With Type 2 Diabetes: A Population‐Based Investigation", "url": "https://doi.org/10.1161/jaha.122.027824"}, {"doi": "10.1186/s12933-022-01455-2", "study": "Efficacy and safety of sodium-glucose cotransporter 2 inhibitors initiation in patients with acute heart failure, with and without type 2 diabetes: a systematic review and meta-analysis", "url": "https://doi.org/10.1186/s12933-022-01455-2"}, {"doi": "10.1161/jaha.120.019463", "study": "Effects of Sodium/Glucose Cotransporter 2 (SGLT2) Inhibitors on Cardiovascular and Metabolic Outcomes in Patients Without Diabetes Mellitus: A Systematic Review and Meta‐Analysis of Randomized‐Controlled Trials", "url": "https://doi.org/10.1161/jaha.120.019463"}, {"doi": "10.1016/j.phrs.2021.105836", "study": "SGLT-2 inhibitors reduce the risk of cerebrovascular/cardiovascular outcomes and mortality: A systematic review and meta-analysis of retrospective cohort studies", "url": "https://doi.org/10.1016/j.phrs.2021.105836"}, {"doi": "10.1093/eurjpc/zwab173", "study": "Effect of sodium-glucose cotransporter-2 inhibitors on cardiac remodelling: a systematic review and meta-analysis", "url": "https://doi.org/10.1093/eurjpc/zwab173"}], "claim": "directionally favorable: Sodium‐Glucose Cotransporter‐2 Inhibitors After Acute Myocardial Infarction in Patients With Type 2 Diabetes: A Population‐Based Investigation — the early use of SGLT2 inhibitors was associated with lower risks of the primary end point (HR 0.68 [95% CI, 0.54-0.87]; P=0.002)", "claim_id": "claim_9"}, {"candidate_sources": [{"doi": "10.1161/jaha.122.027824", "study": "Sodium‐Glucose Cotransporter‐2 Inhibitors After Acute Myocardial Infarction in Patients With Type 2 Diabetes: A Population‐Based Investigation", "url": "https://doi.org/10.1161/jaha.122.027824"}, {"doi": "10.1186/s12933-022-01455-2", "study": "Efficacy and safety of sodium-glucose cotransporter 2 inhibitors initiation in patients with acute heart failure, with and without type 2 diabetes: a systematic review and meta-analysis", "url": "https://doi.org/10.1186/s12933-022-01455-2"}, {"doi": "10.1161/jaha.120.019463", "study": "Effects of Sodium/Glucose Cotransporter 2 (SGLT2) Inhibitors on Cardiovascular and Metabolic Outcomes in Patients Without Diabetes Mellitus: A Systematic Review and Meta‐Analysis of Randomized‐Controlled Trials", "url": "https://doi.org/10.1161/jaha.120.019463"}, {"doi": "10.1016/j.phrs.2021.105836", "study": "SGLT-2 inhibitors reduce the risk of cerebrovascular/cardiovascular outcomes and mortality: A systematic review and meta-analysis of retrospective cohort studies", "url": "https://doi.org/10.1016/j.phrs.2021.105836"}, {"doi": "10.1093/eurjpc/zwab173", "study": "Effect of sodium-glucose cotransporter-2 inhibitors on cardiac remodelling: a systematic review and meta-analysis", "url": "https://doi.org/10.1093/eurjpc/zwab173"}], "claim": "directionally favorable: Efficacy and safety of sodium-glucose cotransporter 2 inhibitors initiation in patients with acute heart failure, with and without type 2 diabetes: a systematic review and meta-analysis — Initiation of SGLT2 inhibitors in patients with AHF reduced the risk of rehospitalization for heart failure (OR 0.52; 95% CI [0.42, 0.65])", "claim_id": "claim_10"}, {"candidate_sources": [{"doi": "10.1161/jaha.122.027824", "study": "Sodium‐Glucose Cotransporter‐2 Inhibitors After Acute Myocardial Infarction in Patients With Type 2 Diabetes: A Population‐Based Investigation", "url": "https://doi.org/10.1161/jaha.122.027824"}, {"doi": "10.1186/s12933-022-01455-2", "study": "Efficacy and safety of sodium-glucose cotransporter 2 inhibitors initiation in patients with acute heart failure, with and without type 2 diabetes: a systematic review and meta-analysis", "url": "https://doi.org/10.1186/s12933-022-01455-2"}, {"doi": "10.1161/jaha.120.019463", "study": "Effects of Sodium/Glucose Cotransporter 2 (SGLT2) Inhibitors on Cardiovascular and Metabolic Outcomes in Patients Without Diabetes Mellitus: A Systematic Review and Meta‐Analysis of Randomized‐Controlled Trials", "url": "https://doi.org/10.1161/jaha.120.019463"}, {"doi": "10.1016/j.phrs.2021.105836", "study": "SGLT-2 inhibitors reduce the risk of cerebrovascular/cardiovascular outcomes and mortality: A systematic review and meta-analysis of retrospective cohort studies", "url": "https://doi.org/10.1016/j.phrs.2021.105836"}, {"doi": "10.1093/eurjpc/zwab173", "study": "Effect of sodium-glucose cotransporter-2 inhibitors on cardiac remodelling: a systematic review and meta-analysis", "url": "https://doi.org/10.1093/eurjpc/zwab173"}], "claim": "directionally favorable: Effects of Sodium/Glucose Cotransporter 2 (SGLT2) Inhibitors on Cardiovascular and Metabolic Outcomes in Patients Without Diabetes Mellitus: A Systematic Review and Meta‐Analysis of Randomized‐Controlled Trials — those with heart failure treated with SGLT2 inhibitors had a 20% relative risk reduction in cardiovascular deaths and heart failure hospitalizations (risk ratio, 0.78; P<0.001).", "claim_id": "claim_11"}, {"candidate_sources": [{"doi": "10.1161/jaha.122.027824", "study": "Sodium‐Glucose Cotransporter‐2 Inhibitors After Acute Myocardial Infarction in Patients With Type 2 Diabetes: A Population‐Based Investigation", "url": "https://doi.org/10.1161/jaha.122.027824"}, {"doi": "10.1186/s12933-022-01455-2", "study": "Efficacy and safety of sodium-glucose cotransporter 2 inhibitors initiation in patients with acute heart failure, with and without type 2 diabetes: a systematic review and meta-analysis", "url": "https://doi.org/10.1186/s12933-022-01455-2"}, {"doi": "10.1161/jaha.120.019463", "study": "Effects of Sodium/Glucose Cotransporter 2 (SGLT2) Inhibitors on Cardiovascular and Metabolic Outcomes in Patients Without Diabetes Mellitus: A Systematic Review and Meta‐Analysis of Randomized‐Controlled Trials", "url": "https://doi.org/10.1161/jaha.120.019463"}, {"doi": "10.1016/j.phrs.2021.105836", "study": "SGLT-2 inhibitors reduce the risk of cerebrovascular/cardiovascular outcomes and mortality: A systematic review and meta-analysis of retrospective cohort studies", "url": "https://doi.org/10.1016/j.phrs.2021.105836"}, {"doi": "10.1093/eurjpc/zwab173", "study": "Effect of sodium-glucose cotransporter-2 inhibitors on cardiac remodelling: a systematic review and meta-analysis", "url": "https://doi.org/10.1093/eurjpc/zwab173"}], "claim": "directionally favorable: SGLT-2 inhibitors reduce the risk of cerebrovascular/cardiovascular outcomes and mortality: A systematic review and meta-analysis of retrospective cohort studies — reduced risk of stroke with SGLT2 inhibitors compared to DPP-4 inhibitors (Hazard ratio HR, 0.89; 95%CI, 0.82-0.96)", "claim_id": "claim_12"}, {"candidate_sources": [{"doi": "10.1161/jaha.122.027824", "study": "Sodium‐Glucose Cotransporter‐2 Inhibitors After Acute Myocardial Infarction in Patients With Type 2 Diabetes: A Population‐Based Investigation", "url": "https://doi.org/10.1161/jaha.122.027824"}, {"doi": "10.1186/s12933-022-01455-2", "study": "Efficacy and safety of sodium-glucose cotransporter 2 inhibitors initiation in patients with acute heart failure, with and without type 2 diabetes: a systematic review and meta-analysis", "url": "https://doi.org/10.1186/s12933-022-01455-2"}, {"doi": "10.1161/jaha.120.019463", "study": "Effects of Sodium/Glucose Cotransporter 2 (SGLT2) Inhibitors on Cardiovascular and Metabolic Outcomes in Patients Without Diabetes Mellitus: A Systematic Review and Meta‐Analysis of Randomized‐Controlled Trials", "url": "https://doi.org/10.1161/jaha.120.019463"}, {"doi": "10.1016/j.phrs.2021.105836", "study": "SGLT-2 inhibitors reduce the risk of cerebrovascular/cardiovascular outcomes and mortality: A systematic review and meta-analysis of retrospective cohort studies", "url": "https://doi.org/10.1016/j.phrs.2021.105836"}, {"doi": "10.1093/eurjpc/zwab173", "study": "Effect of sodium-glucose cotransporter-2 inhibitors on cardiac remodelling: a systematic review and meta-analysis", "url": "https://doi.org/10.1093/eurjpc/zwab173"}], "claim": "Specific moderators in this bundle are population/indication (patients hospitalized with acute heart failure; patients with type 2 diabetes and acute myocardial infarction undergoing percutaneous coronary intervention; patients with type 2 diabetes mellitus; patients with type 2 diabetes mellitus and/or heart failure (13 RCTs, 1251 patients); patients without diabetes mellitus with heart failure), study design/evidence type (primary/review). Single primary-study estimates are separated from pooled review or meta-analytic estimates rather than treated as interchangeable.", "claim_id": "claim_13"}, {"candidate_sources": [{"doi": "10.1161/jaha.122.027824", "study": "Sodium‐Glucose Cotransporter‐2 Inhibitors After Acute Myocardial Infarction in Patients With Type 2 Diabetes: A Population‐Based Investigation", "url": "https://doi.org/10.1161/jaha.122.027824"}, {"doi": "10.1186/s12933-022-01455-2", "study": "Efficacy and safety of sodium-glucose cotransporter 2 inhibitors initiation in patients with acute heart failure, with and without type 2 diabetes: a systematic review and meta-analysis", "url": "https://doi.org/10.1186/s12933-022-01455-2"}, {"doi": "10.1161/jaha.120.019463", "study": "Effects of Sodium/Glucose Cotransporter 2 (SGLT2) Inhibitors on Cardiovascular and Metabolic Outcomes in Patients Without Diabetes Mellitus: A Systematic Review and Meta‐Analysis of Randomized‐Controlled Trials", "url": "https://doi.org/10.1161/jaha.120.019463"}, {"doi": "10.1016/j.phrs.2021.105836", "study": "SGLT-2 inhibitors reduce the risk of cerebrovascular/cardiovascular outcomes and mortality: A systematic review and meta-analysis of retrospective cohort studies", "url": "https://doi.org/10.1016/j.phrs.2021.105836"}, {"doi": "10.1093/eurjpc/zwab173", "study": "Effect of sodium-glucose cotransporter-2 inhibitors on cardiac remodelling: a systematic review and meta-analysis", "url": "https://doi.org/10.1093/eurjpc/zwab173"}], "claim": "The selected receipts group because each carries a fact-level extraction for SGLT2 inhibitors; they separate by context (human clinical/observational) and endpoint, so they are not interchangeable evidence for one pooled claim.", "claim_id": "claim_14"}, {"candidate_sources": [{"doi": "10.1161/jaha.122.027824", "study": "Sodium‐Glucose Cotransporter‐2 Inhibitors After Acute Myocardial Infarction in Patients With Type 2 Diabetes: A Population‐Based Investigation", "url": "https://doi.org/10.1161/jaha.122.027824"}, {"doi": "10.1186/s12933-022-01455-2", "study": "Efficacy and safety of sodium-glucose cotransporter 2 inhibitors initiation in patients with acute heart failure, with and without type 2 diabetes: a systematic review and meta-analysis", "url": "https://doi.org/10.1186/s12933-022-01455-2"}, {"doi": "10.1161/jaha.120.019463", "study": "Effects of Sodium/Glucose Cotransporter 2 (SGLT2) Inhibitors on Cardiovascular and Metabolic Outcomes in Patients Without Diabetes Mellitus: A Systematic Review and Meta‐Analysis of Randomized‐Controlled Trials", "url": "https://doi.org/10.1161/jaha.120.019463"}, {"doi": "10.1016/j.phrs.2021.105836", "study": "SGLT-2 inhibitors reduce the risk of cerebrovascular/cardiovascular outcomes and mortality: A systematic review and meta-analysis of retrospective cohort studies", "url": "https://doi.org/10.1016/j.phrs.2021.105836"}, {"doi": "10.1093/eurjpc/zwab173", "study": "Effect of sodium-glucose cotransporter-2 inhibitors on cardiac remodelling: a systematic review and meta-analysis", "url": "https://doi.org/10.1093/eurjpc/zwab173"}], "claim": "The signal is purely descriptive of effect-direction heterogeneity; it cannot support even a weak causal or comparative-efficacy inference, and pooling across these PICOs would be inappropriate.", "claim_id": "claim_15"}]}

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