Derivation Web

source_ba287a43cce745e1

by researka:v2 · 2026-06-27 10:16:23.715079+04:00

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{"directness": "primary", "doi": "10.1038/s41598-021-00247-0", "risk_of_bias": "not appraised in public sidecar", "study": "TCTP protein degradation by targeting mTORC1 and signaling through S6K, Akt, and Plk1 sensitizes lung cancer cells to DNA-damaging drugs"}, {"directness": "review-level", "doi": "10.1007/s12029-026-01420-2", "risk_of_bias": "not appraised in public sidecar", "study": "Physical Activity and Hepatocellular Carcinoma Outcomes: a Narrative Review of Pre-clinical, Observational, and Interventional Evidence"}, {"directness": "primary", "doi": "10.1016/j.isci.2026.114734", "risk_of_bias": "not appraised in public sidecar", "study": "KNSTRN knockdown impairs autophagy flux to inhibit bladder cancer progression"}, {"directness": "primary", "doi": "10.1016/j.tranon.2026.102688", "risk_of_bias": "not appraised in public sidecar", "study": "The novel tertiary amine LSD1 inhibitor 596 inhibits endometrial cancer through the mTOR signal transduction pathway"}, {"directness": "primary", "doi": "10.1158/1078-0432.CCR-25-4158", "risk_of_bias": "not appraised in public sidecar", "study": "Zanidatamab, a Dual HER2-Targeted Bispecific Antibody, in Patients with Unresectable Locally Advanced or Metastatic HER2-Positive Salivary Gland Cancer: A Combined Analysis of Early-Phase Studies"}, {"directness": "primary", "doi": "10.1021/acsomega.5c02820", "risk_of_bias": "not appraised in public sidecar", "study": "Targeted Delivery of Rapamycin via Epidermal Growth Factor Receptors in Pancreatic Cancer Cells Inhibits Cell Proliferation and Induces Apoptosis"}, {"directness": "review-level", "doi": "10.1186/s12916-023-03238-2", "risk_of_bias": "not appraised in public sidecar", "study": "A network meta-analysis of efficacy and safety for first-line and second/further-line therapies in postmenopausal women with hormone receptor-positive, HER2-negative, advanced breast cancer"}, {"directness": "primary", "doi": "10.3389/fonc.2021.608570", "risk_of_bias": "not appraised in public sidecar", "study": "Rapamycin Antagonizes BCRP-Mediated Drug Resistance Through the PI3K/Akt/mTOR Signaling Pathway in mPRα-Positive Breast Cancer"}, {"directness": "primary", "doi": "10.1186/s12964-025-02385-8", "risk_of_bias": "not appraised in public sidecar", "study": "BEX2 regulates autophagy by inhibiting PIK3CA-p85 interaction in non-small-cell lung cancer cells"}, {"directness": "primary", "doi": "10.1186/s13048-021-00767-3", "risk_of_bias": "not appraised in public sidecar", "study": "Human recombinant arginase I [HuArgI (Co)-PEG5000]-induced arginine depletion inhibits ovarian cancer cell adhesion and migration through autophagy-mediated inhibition of RhoA"}, {"directness": "primary", "doi": "10.1186/1476-4598-8-57", "risk_of_bias": "not appraised in public sidecar", "study": "Depletion of intrinsic expression of Interleukin-8 in prostate cancer cells causes cell cycle arrest, spontaneous apoptosis and increases the efficacy of chemotherapeutic drugs"}, {"directness": "primary", "doi": "10.1186/1756-9966-30-28", "risk_of_bias": "not appraised in public sidecar", "study": "Rapamycin potentiates cytotoxicity by docetaxel possibly through downregulation of Survivin in lung cancer cells"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen."}, {"directness": "citation", "doi": "10.1371/journal.pmed.0020124", "risk_of_bias": "not appraised in public sidecar", "study": "Ioannidis 2005"}]}

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