source · application/json
source_ba9093b65ce44a06
sha256 ea0cdd7e9986978bc55c5bc1e17e56e33b9532717b882d300d41502d78eb1122
by researka:v2 · 2026-05-24 11:44:00.955885+04:00
{"publication_id": "3b113aa9-b186-46fc-b8f4-57f813513544", "traces": [{"candidate_sources": [{"doi": "10.1152/ajpendo.00600.2013", "study": "Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin", "url": null}, {"doi": "10.1158/0008-5472.can-16-3125", "study": "Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development", "url": null}, {"doi": "10.1161/hypertensionaha.114.03510", "study": "Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years", "url": null}, {"doi": "10.1158/1940-6207.capr-20-0188", "study": "Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial", "url": null}, {"doi": "10.1158/1055-9965.epi-13-0337", "study": "Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial", "url": null}], "claim": "Source scope:** 16 A/B-bound receipts across 10 evidence sources; 12 total references in the source bundle. Two source-bundle entries are corpus-context references for breadth, not thesis proof; schema labels still use primary/review only.", "claim_id": "claim_1"}, {"candidate_sources": [{"doi": "10.1152/ajpendo.00600.2013", "study": "Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin", "url": null}, {"doi": "10.1158/0008-5472.can-16-3125", "study": "Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development", "url": null}, {"doi": "10.1161/hypertensionaha.114.03510", "study": "Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years", "url": null}, {"doi": "10.1158/1940-6207.capr-20-0188", "study": "Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial", "url": null}, {"doi": "10.1158/1055-9965.epi-13-0337", "study": "Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial", "url": null}], "claim": "The exercise corpus in this run supports a broader alpha signal: exercise effects are endpoint- and context-specific rather than uniformly generalizable. The strongest bound receipts span inflammatory markers, exercise capacity and mortality, tumor-model response, angiogenesis biomarkers, muscle-protein synthesis, peripheral oxygen extraction, dietary inflammatory index, and NO/exercise muscle effects.", "claim_id": "claim_2"}, {"candidate_sources": [{"doi": "10.1152/ajpendo.00600.2013", "study": "Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin", "url": null}, {"doi": "10.1158/0008-5472.can-16-3125", "study": "Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development", "url": null}, {"doi": "10.1161/hypertensionaha.114.03510", "study": "Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years", "url": null}, {"doi": "10.1158/1940-6207.capr-20-0188", "study": "Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial", "url": null}, {"doi": "10.1158/1055-9965.epi-13-0337", "study": "Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial", "url": null}], "claim": "The common story treats exercise as a single beneficial geroscience intervention. This evidence map says the more useful signal is specificity: different populations, endpoints, and mechanisms move differently, so the publishable claim is not “exercise works,” but “exercise signals need endpoint- and context-specific interpretation.”", "claim_id": "claim_3"}, {"candidate_sources": [{"doi": "10.1152/ajpendo.00600.2013", "study": "Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin", "url": null}, {"doi": "10.1158/0008-5472.can-16-3125", "study": "Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development", "url": null}, {"doi": "10.1161/hypertensionaha.114.03510", "study": "Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years", "url": null}, {"doi": "10.1158/1940-6207.capr-20-0188", "study": "Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial", "url": null}, {"doi": "10.1158/1055-9965.epi-13-0337", "study": "Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial", "url": null}], "claim": "`fact_id=12572` (`A_core`) — Mixed-muscle protein fractional synthetic rate increased by 42% at 3 h postexercise and 69% at 24 h postexercise in CON. DOI `10.1152/ajpendo.00600.2013`", "claim_id": "claim_4"}, {"candidate_sources": [{"doi": "10.1152/ajpendo.00600.2013", "study": "Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin", "url": null}, {"doi": "10.1158/0008-5472.can-16-3125", "study": "Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development", "url": null}, {"doi": "10.1161/hypertensionaha.114.03510", "study": "Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years", "url": null}, {"doi": "10.1158/1940-6207.capr-20-0188", "study": "Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial", "url": null}, {"doi": "10.1158/1055-9965.epi-13-0337", "study": "Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial", "url": null}], "claim": "`fact_id=12573` (`A_core`) — Mixed-muscle protein fractional synthetic rate increased by 42% at 3 h postexercise and 69% at 24 h postexercise in CON. DOI `10.1152/ajpendo.00600.2013`", "claim_id": "claim_5"}, {"candidate_sources": [{"doi": "10.1152/ajpendo.00600.2013", "study": "Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin", "url": null}, {"doi": "10.1158/0008-5472.can-16-3125", "study": "Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development", "url": null}, {"doi": "10.1161/hypertensionaha.114.03510", "study": "Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years", "url": null}, {"doi": "10.1158/1940-6207.capr-20-0188", "study": "Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial", "url": null}, {"doi": "10.1158/1055-9965.epi-13-0337", "study": "Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial", "url": null}], "claim": "`fact_id=12544` (`A_core`) — Mortality risk was 11% lower (hazard ratio, 0.89; 95% confidence interval, 0.86-0.93; P<0.001) for every 1-MET increase in exercise capacity. DOI `10.1161/hypertensionaha.114.03510`", "claim_id": "claim_6"}, {"candidate_sources": [{"doi": "10.1152/ajpendo.00600.2013", "study": "Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin", "url": null}, {"doi": "10.1158/0008-5472.can-16-3125", "study": "Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development", "url": null}, {"doi": "10.1161/hypertensionaha.114.03510", "study": "Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years", "url": null}, {"doi": "10.1158/1940-6207.capr-20-0188", "study": "Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial", "url": null}, {"doi": "10.1158/1055-9965.epi-13-0337", "study": "Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial", "url": null}], "claim": "`fact_id=30392` (`A_core`) — IGF-I/IGFBP-3 ratio increased significantly in the diet + exercise group (+5.4%, P < 0.01) compared with control. DOI `10.1158/1055-9965.epi-13-0337`", "claim_id": "claim_7"}, {"candidate_sources": [{"doi": "10.1152/ajpendo.00600.2013", "study": "Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin", "url": null}, {"doi": "10.1158/0008-5472.can-16-3125", "study": "Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development", "url": null}, {"doi": "10.1161/hypertensionaha.114.03510", "study": "Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years", "url": null}, {"doi": "10.1158/1940-6207.capr-20-0188", "study": "Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial", "url": null}, {"doi": "10.1158/1055-9965.epi-13-0337", "study": "Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial", "url": null}], "claim": "`fact_id=34200` (`A_core`) — NO-donor treatment with isosorbide dinitrate for 6 wk, in combination with voluntary exercise for 3 wk, increased muscle mass by 25% DOI `10.1152/ajpcell.00305.2011`", "claim_id": "claim_8"}, {"candidate_sources": [{"doi": "10.1152/ajpendo.00600.2013", "study": "Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin", "url": null}, {"doi": "10.1158/0008-5472.can-16-3125", "study": "Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development", "url": null}, {"doi": "10.1161/hypertensionaha.114.03510", "study": "Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years", "url": null}, {"doi": "10.1158/1940-6207.capr-20-0188", "study": "Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial", "url": null}, {"doi": "10.1158/1055-9965.epi-13-0337", "study": "Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial", "url": null}], "claim": "2. Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development (2017). DOI `10.1158/0008-5472.can-16-3125` — `primary`", "claim_id": "claim_9"}, {"candidate_sources": [{"doi": "10.1152/ajpendo.00600.2013", "study": "Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin", "url": null}, {"doi": "10.1158/0008-5472.can-16-3125", "study": "Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development", "url": null}, {"doi": "10.1161/hypertensionaha.114.03510", "study": "Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years", "url": null}, {"doi": "10.1158/1940-6207.capr-20-0188", "study": "Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial", "url": null}, {"doi": "10.1158/1055-9965.epi-13-0337", "study": "Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial", "url": null}], "claim": "10. Nitric oxide and voluntary exercise together promote quadriceps hypertrophy and increase vascular density in female 18-mo-old mice (2012). DOI `10.1152/ajpcell.00305.2011` — `primary`", "claim_id": "claim_10"}, {"candidate_sources": [{"doi": "10.1152/ajpendo.00600.2013", "study": "Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin", "url": null}, {"doi": "10.1158/0008-5472.can-16-3125", "study": "Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development", "url": null}, {"doi": "10.1161/hypertensionaha.114.03510", "study": "Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years", "url": null}, {"doi": "10.1158/1940-6207.capr-20-0188", "study": "Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial", "url": null}, {"doi": "10.1158/1055-9965.epi-13-0337", "study": "Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial", "url": null}], "claim": "Do not treat exercise as one generic anti-aging lever in review or trial design. Split claims by endpoint family before making a broad conclusion: inflammation, tumor biology, vascular oxygenation, muscle synthesis, mortality/exercise capacity, and diet-linked biomarker changes are different evidence lanes.", "claim_id": "claim_11"}, {"candidate_sources": [{"doi": "10.1152/ajpendo.00600.2013", "study": "Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin", "url": null}, {"doi": "10.1158/0008-5472.can-16-3125", "study": "Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development", "url": null}, {"doi": "10.1161/hypertensionaha.114.03510", "study": "Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years", "url": null}, {"doi": "10.1158/1940-6207.capr-20-0188", "study": "Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial", "url": null}, {"doi": "10.1158/1055-9965.epi-13-0337", "study": "Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial", "url": null}], "claim": "The topic is heterogeneous, so the memo should guide subtopic extraction rather than support one pooled treatment-effect claim.", "claim_id": "claim_12"}, {"candidate_sources": [{"doi": "10.1152/ajpendo.00600.2013", "study": "Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin", "url": null}, {"doi": "10.1158/0008-5472.can-16-3125", "study": "Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development", "url": null}, {"doi": "10.1161/hypertensionaha.114.03510", "study": "Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years", "url": null}, {"doi": "10.1158/1940-6207.capr-20-0188", "study": "Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial", "url": null}, {"doi": "10.1158/1055-9965.epi-13-0337", "study": "Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial", "url": null}], "claim": "No A_core/B_context counter-evidence was classified in this run, but the heterogeneity of endpoints is itself a constraint on broad claims.", "claim_id": "claim_13"}, {"candidate_sources": [{"doi": "10.1152/ajpendo.00600.2013", "study": "Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin", "url": null}, {"doi": "10.1158/0008-5472.can-16-3125", "study": "Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development", "url": null}, {"doi": "10.1161/hypertensionaha.114.03510", "study": "Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years", "url": null}, {"doi": "10.1158/1940-6207.capr-20-0188", "study": "Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial", "url": null}, {"doi": "10.1158/1055-9965.epi-13-0337", "study": "Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial", "url": null}], "claim": "Re-run counter-evidence search against each child topic so “no counter-evidence found” is not confused with proof of absence.", "claim_id": "claim_14"}, {"candidate_sources": [{"doi": "10.1152/ajpendo.00600.2013", "study": "Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin", "url": null}, {"doi": "10.1158/0008-5472.can-16-3125", "study": "Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development", "url": null}, {"doi": "10.1161/hypertensionaha.114.03510", "study": "Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years", "url": null}, {"doi": "10.1158/1940-6207.capr-20-0188", "study": "Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial", "url": null}, {"doi": "10.1158/1055-9965.epi-13-0337", "study": "Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial", "url": null}], "claim": "Suggested citation:** Dom Lynch. (2026). Exercise signals are endpoint-specific, not uniformly generalizable. ReseaRka Evidence Index. Version 1.0.", "claim_id": "claim_15"}]}
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