Derivation Web

source_bdaa0cc04a52459c

by researka:v2 · 2026-06-22 14:58:19.721890+04:00

{"content_hash": null, "edges": [{"from": "9fd402e5-02e8-4ac2-acd2-1c6bf571b6e5", "to": "claim_1", "type": "contains_claim"}, {"from": "9fd402e5-02e8-4ac2-acd2-1c6bf571b6e5", "to": "claim_2", "type": "contains_claim"}, {"from": "9fd402e5-02e8-4ac2-acd2-1c6bf571b6e5", "to": "claim_3", "type": "contains_claim"}, {"from": "9fd402e5-02e8-4ac2-acd2-1c6bf571b6e5", "to": "claim_4", "type": "contains_claim"}, {"from": "9fd402e5-02e8-4ac2-acd2-1c6bf571b6e5", "to": "claim_5", "type": "contains_claim"}], "nodes": [{"id": "9fd402e5-02e8-4ac2-acd2-1c6bf571b6e5", "title": "fisetin: receipt-backed evidence fronts", "type": "publication"}, {"id": "claim_1", "text": "What evidence fronts does fisetin occupy across animal model, cell or in-vitro model, and chemistry/formulation, and what remains untested?", "type": "claim"}, {"id": "claim_2", "text": "Finding: DHC and fisetin caused dose-dependent reduction in viability and increase in apoptosis in PC3 cells at 72 h.", "type": "claim"}, {"id": "claim_3", "text": "Answer: this 5-source primary bundle supports a receipt-backed scoping note for fisetin, spanning 2010-2023. The source facts cover 5 population context(s) and 5 intervention/exposure context(s). The bounded signal is context separation across animal model, cell or in-vitro model, and chemistry/formulation: the bundle identifies what has been measured and where the evidence separates, without establishing a causal, clinical, species-translated, or mechanistically integrated intervention claim. Representative source-extracted findings include: IC50 of fisetin 3.4 ± 0.3 μM on senescent cells versus 7.0 ± 0.4 μM on control cells; a 2.5-fold increase of fisetin solubility was achieved for FisNam; Fisetin (<20 µM) restored cell viability and repressed apoptosis, autophagy and ROS production in Tm-treated cells.", "type": "claim"}, {"id": "claim_4", "text": "The selected receipts group because each carries a fact-level extraction for fisetin; they separate by context (animal model, cell or in-vitro model, and chemistry/formulation), so they are not interchangeable evidence for one endpoint.", "type": "claim"}, {"id": "claim_5", "text": "Source-literature boundary for fisetin: the listed sources define separate evidence fronts. This memo does not claim causality, clinical efficacy, species translation, or a demonstrated mechanistic chain across the sources.", "type": "claim"}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1111/acel.14060", "effect": "not extracted", "endpoint": "not extracted", "id": "source_1", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/38062873/", "year": 2023}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1039/c4ce01713g", "effect": "not extracted", "endpoint": "not extracted", "id": "source_2", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Improving solubility of fisetin by cocrystallization", "type": "source", "url": null, "year": 2014}, {"comparator": "not extracted", "directness": "primary", "doi": "10.3390/ijms18040852", "effect": "not extracted", "endpoint": "not extracted", "id": "source_3", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Fisetin Protects PC12 Cells from Tunicamycin-Mediated Cell Death via Reactive Oxygen Species Scavenging and Modulation of Nrf2-Driven Gene Expression, SIRT1 and MAPK Signaling in PC12 Cells", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/28420170/", "year": 2017}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1080/01635581003605524", "effect": "not extracted", "endpoint": "not extracted", "id": "source_4", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/20574928/", "year": 2010}, {"comparator": "not extracted", "directness": "primary", "doi": "10.18632/aging.204275", "effect": "not extracted", "endpoint": "not extracted", "id": "source_5", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Senolytic elimination of senescent macrophages restores muscle stem cell function in severely dystrophic muscle", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/36084954/", "year": 2022}], "publication_id": "9fd402e5-02e8-4ac2-acd2-1c6bf571b6e5", "screening": {"excluded": 0, "exclusion_reasons": ["No PRISMA full-text exclusion-stage filter was applied."], "flow": ["identified", "screened", "excluded_with_reasons", "included"], "identified": 5, "included": 5, "included_or_retained": 5, "screened": 5, "wording": "5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit."}}

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