Derivation Web

source_c0768783b20f4ce5

by researka:v2 · 2026-06-25 09:00:22.347655+04:00

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
"Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Evaluating the Impact of Urolithin A Supplementation on Running Performance, Recovery, and Mitochondrial Biomarkers in Highly Trained Male Distance Runners",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effect of urolithin A on the improvement of vascular endothelial function depends on the gut microbiota,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Ameliorative Effects of Urolithin A Against Cadmium-Induced NLRP3-Mediated Pyroptosis and Cognitive Deficits Via Regulating Aryl Hydrocarbon Receptor Signaling,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Urolithin A provides cardioprotection and mitochondrial quality enhancement preclinically and improves human cardiovascular health biomarkers,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Assessment of Urolithin A effects on muscle endurance, strength, inflammation, oxidative stress, and protein metabolism in male athletes with resistance training: an 8-week randomized, double-blind, placebo-controlled study",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effects of Urolithin A supplementation on performance and antioxidant status in academy soccer players during preseason: a pilot randomised controlled trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effects of Urolithin A on Mitochondrial Parameters in a Cellular Model of Early Alzheimer Disease,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Absorption and Metabolism of Urolithin A and Ellagic Acid in Mice and Their Cytotoxicity in Human Colorectal Cancer Cells,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The polyphenol metabolite urolithin A suppresses myostatin expression and augments glucose uptake in human skeletal muscle cells,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Urolithin A Protects Chondrocytes From Mechanical Overloading-Induced Injuries,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Mitophagy Activation by Urolithin A to Target Muscle Aging,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Functionalized hydrogels of CeO 2 and Urolithin A synergistically scavenge ROS and activate mitophagy for cartilage repair,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The gut microbiota metabolite urolithin A inhibits NF-κB activation in LPS stimulated BMDMs,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Urolithin A and nicotinamide riboside differentially regulate innate immune defenses and metabolism in human microglial cells,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
In vitro conversion of ellagic acid to urolithin A by different gut microbiota of urolithin metabotype A,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Urolithin A Protects Hepatocytes from Palmitic Acid-Induced ER Stress by Regulating Calcium Homeostasis in the MAM,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Diet-derived urolithin A is produced by a dehydroxylase encoded by human gut Enterocloster species,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Urolithin A supplementation alleviates osteogenic disfunction and promotes bone fracture healing in inflammatory environments,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Urolithin A Alleviates Doxorubicin-Induced Senescence in Mesenchymal Stem Cells,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Urolithin A enhances muscle performance in elderly and positively impacts biomarkers linked to cellular health,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Urolithin A enhances muscle performance in elderly and positively impacts biomarkers linked to cellular health,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Mitigating Pro‐Inflammatory SASP and DAMP With Urolithin A: A Novel Senomorphic Strategy,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Topical application of Urolithin A slows intrinsic skin aging and protects from UVB-mediated photodamage: Findings from Randomized Clinical Trials,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Influence of the Urolithin A on the Population With BMI Higher Than 30 During Restricted Eating.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Urolithin A: a multi-target therapeutic candidate derived from the gut microbiota for obesity and metabolic dysfunction,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Microbial Metabolite, Macro Impact: Urolithin A in the Nexus of Insulin Resistance and Colorectal Tumorigenesis",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Evaluation of Urolithin A Efficacy in Heart Failure Patients with Reduced Ejection Fraction: A Randomized, Double-blind, Crossover, Placebo-controlled Clinical Trial.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"The effects of urolithin A supplementation on muscle strength, muscle mass and physical performance in humans - a systematic review",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Sulforaphane, Urolithin A, and ZLN005 induce time-dependent alterations in antioxidant capacity, mitophagy, and mitochondrial biogenesis in muscle cells",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Evaluation of Urolithin A and Fisetin on Improving Sleep and Aging Biomarkers,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Urolithin A supplementation to improve endothelial and cerebrovascular function in middle-aged adults with obesity: Study protocol for a double-blind placebo-controlled randomized study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Impact of urolithin A supplementation, a mitophagy activator on mitochondrial health of immune cells (MitoIMMUNE): A randomized, double-blind, placebo-controlled trial in healthy adults.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Ellagitannins (Ellagic Acid, Urolithin A, Urolithin B) Inhibit the Catalytic Activity of Human Recombinant Metalloproteinase 9",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Targeting aging with urolithin A in humans: A systematic review.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Unveiling the potential of Urolithin A in Cancer Therapy: Mechanistic Insights to Future Perspectives of Nanomedicine,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Unripe Rubus occidentalis , Ellagic Acid, and Urolithin A Attenuate Inflammatory Responses in IL-1β-Stimulated A549 Cells and PMA-Stimulated Differentiated HL-60 Cells",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Urolithin A Supplementation in Middle-aged Adults With Obesity,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Urolithin A in Central Nervous System Disorders: Therapeutic Applications and Challenges,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Effects of Mitopure (Urolithin A) on Skeletal Muscle Function, Iron Metabolism and Endurance Performance",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Pomegranate Juice Metabolites, Ellagic Acid and Urolithin A, Synergistically Inhibit Androgen-Independent Prostate Cancer Cell Growth via Distinct Effects on Cell Cycle Control and Apoptosis",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Pomegranate ellagitannin metabolite, Urolithin A, inhibits prostate cancer cell proliferation via inhibition of IGF‐1 signaling pathway",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
The Effect of Urolithin A (Mitopure®) Supplementation on Muscle Strength in Healthy Middle-Aged Adults,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55 >= Years Old: A Randomized Triple-Masked Controlled Clinical Trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Urolithin a Enhances Muscle 2021,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Influence of the Urolithin a on the Population 2026,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Evaluation of Urolithin a and Fisetin 2026,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Effect of Urolithin a Mitopure n.d.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Effects of Mitopure Urolithin 2022,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Effects of Urolithin a Supplementation n.d.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Urolithin a Supplementation in Middle-aged 2025,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Perera 2006,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
WHO 2000,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Cruz-Jentoft 2019,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Anisimov 2008,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Ioannidis 2005,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation

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