Derivation Web

source_c08f5ec764d3423f

by researka:v2 · 2026-06-15 01:09:06.960608+04:00

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "24f229e0-b6b2-4735-912f-34831eeac380", "sources": [{"directness": "primary", "doi": "10.2337/dc24-1597", "risk_of_bias": "not appraised in public sidecar", "study": "Metformin Treatment With or Without Mediterranean Diet for the Prevention of Age-Related Diseases in People With Metabolic Syndrome: The MeMeMe Randomized Trial"}, {"directness": "review-level", "doi": "10.1111/acel.13733", "risk_of_bias": "not appraised in public sidecar", "study": "Metformin has heterogeneous effects on model organism lifespans and is beneficial when started at an early age in Caenorhabditis elegans : A systematic review and meta‐analysis"}, {"directness": "primary", "doi": "10.1038/s41467-025-67087-8", "risk_of_bias": "not appraised in public sidecar", "study": "Letrozole, abemaciclib and metformin in endometrial cancer: a non-randomized phase 2 trial"}, {"directness": "primary", "doi": "10.1093/jncics/pkad017", "risk_of_bias": "not appraised in public sidecar", "study": "Association of metformin, aspirin, and cancer incidence with mortality risk in adults with diabetes"}, {"directness": "primary", "doi": "10.3390/ijms27104195", "risk_of_bias": "not appraised in public sidecar", "study": "Do We Have Enough Evidence That Metformin Is Superior to Other Antidiabetic Drugs in Pancreatic Cancer Risk Reduction?"}, {"directness": "primary", "doi": "10.1038/s41467-025-56914-7", "risk_of_bias": "not appraised in public sidecar", "study": "Olaparib combined to metronomic cyclophosphamide and metformin in women with recurrent advanced/metastatic endometrial cancer: the ENDOLA phase I/II trial"}, {"directness": "review-level", "doi": "10.3390/medicina61061021", "risk_of_bias": "not appraised in public sidecar", "study": "Metformin: A Dual-Role Player in Cancer Treatment and Prevention: A Comprehensive Systematic Review and Meta-Analysis"}, {"directness": "primary", "doi": "10.1038/s41598-025-09393-1", "risk_of_bias": "not appraised in public sidecar", "study": "Metformin and weight loss medication impact on survival outcomes in older women with obesity-related cancers"}, {"directness": "review-level", "doi": "10.1002/jcsm.13509", "risk_of_bias": "not appraised in public sidecar", "study": "Effects of exercise or metformin on myokine concentrations in patients with breast and colorectal cancer: A phase II multi‐centre factorial randomized trial"}, {"directness": "primary", "doi": "10.1590/1414-431X2024e14060", "risk_of_bias": "not appraised in public sidecar", "study": "Clenbuterol and metformin ameliorate cachexia parameters, but only clenbuterol reduces tumor growth via lipid peroxidation in Walker 256 tumor-bearing rats"}, {"directness": "review-level", "doi": "10.1371/journal.pone.0310687", "risk_of_bias": "not appraised in public sidecar", "study": "Association of metformin use with risk and survival outcome of esophageal cancer in patients with diabetes: A systematic review and meta-analysis"}, {"directness": "review-level", "doi": "10.3389/fphar.2026.1752095", "risk_of_bias": "not appraised in public sidecar", "study": "Efficacy of metformin as an adjuvant therapy in gynecologic malignancies: a meta-analysis of randomized controlled trials"}, {"directness": "primary", "doi": "10.1158/1940-6207.CAPR-25-0104", "risk_of_bias": "not appraised in public sidecar", "study": "Time-Restricted Eating and Metformin in Invasive Breast Cancer or DCIS: A Randomized, Phase IIb, Presurgical Trial. Preliminary Safety Analysis"}, {"directness": "review-level", "doi": "10.1038/s41416-025-03070-w", "risk_of_bias": "not appraised in public sidecar", "study": "Statin use and breast cancer-specific mortality and recurrence: a systematic review and meta-analysis including the role of immortal time bias and tumour characteristics"}, {"directness": "primary", "doi": "10.1158/1078-0432.CCR-25-1098", "risk_of_bias": "not appraised in public sidecar", "study": "Extracellular Matrix–MYCAF Signatures Correlate with Resistance to Neoadjuvant aPD-L1 Immune Checkpoint Inhibition with Durvalumab + Metformin in HPV+ HNSCC"}, {"directness": "review-level", "doi": "10.2340/1651-226X.2025.43045", "risk_of_bias": "not appraised in public sidecar", "study": "Tolerability, safety and feasibility of metformin combined with chemoradiotherapy in patients with locally advanced cervical cancer: a phase II, randomized study"}, {"directness": "review-level", "doi": "10.3389/fphar.2025.1710176", "risk_of_bias": "not appraised in public sidecar", "study": "Effectiveness of drug-loaded poly(ethylene glycol) and poly(lactic-co-glycolic-acid) nanoparticles in the in vitro treatment of breast cancer: a systematic review"}, {"directness": "primary", "doi": "10.2196/79739", "risk_of_bias": "not appraised in public sidecar", "study": "Smartphone-Based Physical Activity Program to Reduce “Chemo-Brain” Symptoms and Improve Health in Cancer Survivors With and Without Type 2 Diabetes: Protocol for a Single-Arm Pre-Post Pilot Trial"}, {"directness": "primary", "doi": "10.1038/s41598-025-01705-9", "risk_of_bias": "not appraised in public sidecar", "study": "Effects of metformin on transcriptomic and metabolomic profiles in breast cancer survivors enrolled in the randomized placebo-controlled MetBreCS trial"}, {"directness": "primary", "doi": "10.3389/fimmu.2024.1526481", "risk_of_bias": "not appraised in public sidecar", "study": "Bibliometric analysis of metformin as an immunomodulator (2013–2024)"}, {"directness": "primary", "doi": "10.1136/bmjopen-2026-117537", "risk_of_bias": "not appraised in public sidecar", "study": "Association between preoperative metformin exposure and postoperative nausea and vomiting in patients undergoing general anaesthesia: a protocol for a prospective observational cohort study in a Chinese tertiary hospital"}, {"directness": "review-level", "doi": "10.1056/nejm198812293192604", "risk_of_bias": "not appraised in public sidecar", "study": "**Tinetti 1988.** _Tinetti ME, Speechley M, Ginter SF. Risk factors for falls among elderly persons living in the community. N Engl J Med. 1988;319(26):1701-1707._ DOI: 10.1056/NEJM198812293192604. PMID: 3205267."}, {"directness": "review-level", "doi": "10.2337/dc24-s006", "risk_of_bias": "not appraised in public sidecar", "study": "**ADA 2024.** _American Diabetes Association. Standards of Care in Diabetes. Diabetes Care. 2024;47(Suppl 1)._ DOI: 10.2337/dc24-S006."}, {"directness": "review-level", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Owen 2000.** _Owen MR, Doran E, Halestrap AP. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem J. 2000;348 Pt 3:607-614._ PMID: 10839993."}, {"directness": "review-level", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Anisimov 2008.** _Anisimov VN, Berstein LM, Egormin PA, et al. Metformin slows down aging and extends life span of female SHR mice. Cell Cycle. 2008;7(17):2769-2773._ PMID: 18728386."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen."}]}

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  "researka_submission_id": "20db358e-4697-4954-87cf-39e340145b6b",
  "sidecar_name": "risk_of_bias.json",
  "sidecar_url": "https://api.researka.org/publications/24f229e0-b6b2-4735-912f-34831eeac380/sidecars/risk_of_bias.json"
}