Derivation Web

source_c0e135cd3129475d

by researka:v2 · 2026-05-27 16:11:01.403137+04:00

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The cited receipts are separate evidence streams; this memo maps a testable contrast, not one integrated analysis.", "type": "claim"}, {"id": "claim_3", "text": "Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication.", "type": "claim"}, {"id": "claim_4", "text": "The discordance between acarbose's pronounced male-specific lifespan extension in genetically heterogeneous mice and its female-preferential dementia risk reduction in human type 2 diabetes patients suggests that sex-hormone interactions or differential gut-brain axis modulation may underpin its geroprotective effects, inviting mechanistic studies beyond glucose lowering.", "type": "claim"}, {"id": "claim_5", "text": "Real tension: Acarbose increased median lifespan by 22% in male mice but only 5% in female mice (facts 3,4), whereas in human T2D patients, it reduced dementia risk only in women with an HR of 0.783 (fact 12).", "type": "claim"}, {"id": "claim_6", "text": "`fact_id=187300` (`A_core`) — reduced risk associated with acarbose was only observed... in non-users of metformin (adjusted hazard ratio, 0.635; 95% confidence interval, 0.481-0.837) doi=10.14336/ad.2019.0621", "type": "claim"}, {"id": "claim_7", "text": "`fact_id=187299` (`A_core`) — users of all three drugs had the lowest risk of dementia (hazard ratio, 0.406; 95% confidence interval, 0.178-0.925) doi=10.14336/ad.2019.0621", "type": "claim"}, {"id": "claim_8", "text": "`fact_id=135514` (`A_core`) — The mean HbA1c at week 24 was significantly decreased approximately 0.7% from baseline in both acarbose and voglibose groups. doi=10.3346/jkms.2014.29.1.90", "type": "claim"}, {"id": "claim_9", "text": "`fact_id=70369` (`A_core`) — Acarbose increased male median lifespan by 22% (P < 0.0001) doi=10.1111/acel.12170", "type": "claim"}, {"id": "claim_10", "text": "`fact_id=135510` (`A_core`) — acarbose produced 51% decrease in maltose loaded diabetic rats doi=10.4236/jdm.2012.21013", "type": "claim"}, {"id": "claim_11", "text": "`fact_id=108410` (`A_core`) — significantly increased (3%) in females only at 1,000 ppm doi=10.1111/acel.12898", "type": "claim"}, {"id": "claim_12", "text": "_No A_core/B_context counter-evidence found in this run; treat this as a single-direction signal until a broader receipt expansion finds a real opposing fact._", "type": "claim"}, {"id": "claim_13", "text": "Suggested citation:** Dom Lynch. (2026). Polypharmacy Strategies with Acarbose for Dementia Risk Reduction in Type 2 Diabetes: Evidence from Subgroup Analyses and Combination Therapy. ReseaRka Evidence Index. Version 1.0.", "type": "claim"}, {"id": "claim_14", "text": "Priority note:** This memo records the first published framing, source bundle, and evidence receipts for this run. Reuse should cite the canonical version.", "type": "claim"}, {"comparator": "not extracted", "directness": "primary", "doi": "10.14336/ad.2019.0621", "effect": "not extracted", "endpoint": "not extracted", "id": "source_1", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Dementia Risk in Type 2 Diabetes Patients: Acarbose Use and Its Joint Effects with Metformin and Pioglitazone", "type": "source", "url": null, "year": 2020}, {"comparator": "not extracted", "directness": "primary", "doi": "10.3346/jkms.2014.29.1.90", "effect": "not extracted", "endpoint": "not extracted", "id": "source_2", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Comparison of Acarbose and Voglibose in Diabetes Patients Who Are Inadequately Controlled with Basal Insulin Treatment: Randomized, Parallel, Open-Label, Active-Controlled Study", "type": "source", "url": null, "year": 2014}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1111/acel.12170", "effect": "not extracted", "endpoint": "not extracted", "id": "source_3", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males.", "type": "source", "url": null, "year": 2014}, {"comparator": "not extracted", "directness": "primary", "doi": "10.4236/jdm.2012.21013", "effect": "not extracted", "endpoint": "not extracted", "id": "source_4", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats", "type": "source", "url": null, "year": 2012}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1111/acel.12898", "effect": "not extracted", "endpoint": "not extracted", "id": "source_5", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Acarbose improves health and lifespan in aging HET3 mice", "type": "source", "url": null, "year": 2019}, {"comparator": "not extracted", "directness": "citation", "doi": null, "effect": "not extracted", "endpoint": "not extracted", "id": "source_6", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "**Topic:** `acarbose`", "type": "source", "url": null, "year": null}, {"comparator": "not extracted", "directness": "citation", "doi": null, "effect": "not extracted", "endpoint": "not extracted", "id": "source_7", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "**Author:** Dom Lynch", "type": "source", "url": null, "year": null}, {"comparator": "not extracted", "directness": "citation", "doi": null, "effect": "not extracted", "endpoint": "not extracted", "id": "source_8", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "**ORCID:** _not configured_", "type": "source", "url": null, "year": null}, {"comparator": "not extracted", "directness": "citation", "doi": null, "effect": "not extracted", "endpoint": "not extracted", "id": "source_9", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "**Version:** 1.0", "type": "source", "url": null, "year": null}, {"comparator": "not extracted", "directness": "citation", "doi": null, "effect": "not extracted", "endpoint": "not extracted", "id": "source_10", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "**License:** CC BY-NC 4.0", "type": "source", "url": null, "year": null}, {"comparator": "not extracted", "directness": "citation", "doi": null, "effect": "not extracted", "endpoint": "not extracted", "id": "source_11", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "**Canonical URL:** _not assigned_", "type": "source", "url": null, "year": null}, {"comparator": "not extracted", "directness": "citation", "doi": null, "effect": "not extracted", "endpoint": "not extracted", "id": "source_12", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "**Suggested citation:** Dom Lynch. 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