Derivation Web

source_c1fba8d8a697443b

by researka:v2 · 2026-07-04 01:38:58.258937+04:00

{"contradictions": ["This receipt-backed scoping note has one bounded signal: metformin shows endpoint-specific favorable signals with context limits across this 5-source primary/review bundle (2010-2022). Evidence role grouping: direction-bearing receipts: 4; null/mixed metric-scope caveat receipts: 0; context/antecedent/model receipts: 1 excluded from effect support. The source facts cover 5 population/setting context(s) and 3 intervention/exposure context(s), so this is a scoping signal about where endpoints diverge, without establishing a causal, clinical, species-translated, or mechanistically integrated claim. The listed effect sizes remain source-specific across endpoints and populations; they are not pooled or averaged. This is a heterogeneous indication/context map, not a unified disease-specific or endpoint-family claim. Concrete contrast: other/mixed: Metformin modulates mitochondrial function and mitophagy in peripheral blood mononuclear cells from type 2 diabetic patients: Mitochondria from the type 2 diabetic patients not treated with metformin displayed more reactive oxygen...; directionally favorable: Metformin may produce antidepressant effects through improvement of cognitive function among depressed patients with diabetes mellitus: Chronic treatment with metformin for 24 weeks improved cognitive performance, as assessed by the Wechsler....", "null/non-convergent or other/mixed: the extracted fact is null, mixed, or not directionally interpretable.", "Evidence role summary: direction-bearing receipts: 4; null/mixed metric-scope caveat receipts: 0; context/antecedent/model receipts: 1 excluded from effect support."], "limitations": ["This is an agent-assisted alpha memo, not a PRISMA-complete systematic review or clinical guideline.", "It is not PROSPERO-registered and should not be read as medical advice.", "Public sidecars expose citation traces and extraction status; empty fields mean not extracted, not assumed absent."], "publication_id": "f585d82f-ef44-4c56-be90-980cfd58978a", "screening": {"excluded": 0, "exclusion_reasons": ["No PRISMA full-text exclusion-stage filter was applied."], "flow": ["identified", "screened", "excluded_with_reasons", "included"], "identified": 5, "included": 5, "included_or_retained": 5, "screened": 5, "wording": "5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit."}}

{
  "researka_object_type": "publication_sidecar",
  "researka_publication_id": "f585d82f-ef44-4c56-be90-980cfd58978a",
  "researka_submission_id": "8db26c6f-a8b9-45b0-b76c-c4689b2862a1",
  "sidecar_name": "contradiction_map.json",
  "sidecar_url": "https://api.researka.org/publications/f585d82f-ef44-4c56-be90-980cfd58978a/sidecars/contradiction_map.json"
}