Derivation Web

source_c3919a3e2e8d49cc

by researka:v2 · 2026-06-08 22:16:13.562160+04:00

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
"Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"NAD + -Precursor Supplementation With L-Tryptophan, Nicotinic Acid, and Nicotinamide Does Not Affect Mitochondrial Function or Skeletal Muscle Function in Physically Compromised Older Adults",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Development of a 31 P magnetic resonance spectroscopy technique to quantify NADH and NAD + at 3 T,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Meta-analysis of niacin and NAD metabolite treatment in infectious disease animal studies suggests benefit but requires confirmation in clinically relevant models,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Nicotinamide riboside with pterostilbene (NRPT) increases NAD + in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Cardioprotecive Properties of Known Agents in Rat Ischemia-Reperfusion Model Under Clinically Relevant Conditions: Only the NAD Precursor Nicotinamide Riboside Reduces Infarct Size in Presence of Fentanyl, Midazolam and Cangrelor, but Not Propofol",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"A Combination of Nicotinamide and D-Ribose (RiaGev) Is Safe and Effective to Increase NAD + Metabolome in Healthy Middle-Aged Adults: A Randomized, Triple-Blind, Placebo-Controlled, Cross-Over Pilot Clinical Trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Refining Prognosis in Cirrhosis Patients With Ascites: Impact of Acute vs. Non‐Acute Decompensation,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Effect of Nicotinamide Adenine Dinucleotide on Heart Failure Caused by Ischemic Cardiomyopathy: A Randomized, Placebo-Controlled Trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
NAD metabolism modulates inflammation and mitochondria function in diabetic kidney disease,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effects of Nicotinamide Adenine Dinucleotide on Older Patients with Heart Failure,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Relationship between sperm NAD + concentration and reproductive aging in normozoospermia men:A Cohort study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
NAD+-Increasing Strategies to Improve Cardiometabolic Health?,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Nicotinamide Riboside Supplementation for Treating Elevated Systolic Blood Pressure and Arterial Stiffness in Midlife and Older Adults,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"The complexity of nicotinamide adenine dinucleotide (NAD), hypoxic, and aryl hydrocarbon receptor cell signaling in chronic kidney disease",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
A systematic review of the therapeutic potential of nicotinamide adenine dinucleotide precursors for cognitive diseases in preclinical rodent models,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Nicotinamide Mononucleotide Restores NAD + Levels to Alleviate LPS-Induced Inflammation via the TLR4/NF-κB/MAPK Signaling Pathway in Mice Granulosa Cells,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Rebalancing of mitochondrial homeostasis through an NAD + -SIRT1 pathway preserves intestinal barrier function in severe malnutrition,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Sauchinone alleviates dextran sulfate sodium-induced ulcerative colitis via NAD(P)H dehydrogenase [quinone] 1/NF-kB pathway and gut microbiota,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
A Liposomal Formulation Enhances the Anti-Senescence Properties of Nicotinamide Adenine-Dinucleotide (NAD + ) in Endothelial Cells and Keratinocytes,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Trigonelline is an NAD + precursor that improves muscle function during ageing and is reduced in human sarcopenia,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The impacts of continuous improvements in air quality on mortality in Beijing: A longitudinal comparative study.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Safety Evaluation for Restorin® NMN, a NAD+ Precursor",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Unveiling the role of NAD glycohydrolase CD38 in aging and age-related diseases: insights from bibliometric analysis and comprehensive review,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD + in healthy middle-aged and older adults,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD + Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
ADA 2024,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
WHO 2000,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Ioannidis 2005,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation

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