Derivation Web

source_c494db0083744628

by researka:v2 · 2026-06-27 00:22:43.791284+04:00

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "d8e97ad6-d465-4e84-8231-2402678c670c", "sources": [{"directness": "primary", "doi": "10.1161/JAHA.125.042610", "risk_of_bias": "not appraised in public sidecar", "study": "Integrating Vascular Aging and Genetic Risk: The Combined Impact of Estimated Pulse Wave Velocity and Genetic Predisposition on Coronary Artery Disease"}, {"directness": "primary", "doi": "10.1111/acel.70457", "risk_of_bias": "not appraised in public sidecar", "study": "Endothelial Sirtuins and Mitochondrial Function Are Associated With Testosterone Status: Implications for Accelerated Vascular Aging in Middle‐Age and Older Men With Low Testosterone"}, {"directness": "primary", "doi": "10.3390/s24175832", "risk_of_bias": "not appraised in public sidecar", "study": "Impact of a Precision Intervention for Vascular Health in Middle-Aged and Older Postmenopausal Women Using Polar Heart Rate Sensors: A 24-Week RCT Study Based on the New Compilation of Tai Chi (Bafa Wubu)"}, {"directness": "primary", "doi": "10.1161/JAHA.122.028116", "risk_of_bias": "not appraised in public sidecar", "study": "The EVA Study: Early Vascular Aging in Women With History of Preeclampsia"}, {"directness": "primary", "doi": "10.3389/fpubh.2025.1723100", "risk_of_bias": "not appraised in public sidecar", "study": "Vascular age as a key for a team-based approach to manage blood pressure bridging community pharmacists and primary healthcare physicians—The TOGETHER trial"}, {"directness": "primary", "doi": "10.1161/JAHA.124.037718", "risk_of_bias": "not appraised in public sidecar", "study": "Accelerated Vascular Aging as a Possible Mechanism of Troponin I Release in the Absence of Clinically Manifested Myocardial Injury"}, {"directness": "review-level", "doi": "10.3389/fnut.2025.1632952", "risk_of_bias": "not appraised in public sidecar", "study": "Effects of L-citrulline supplementation and watermelon intake on arterial stiffness and endothelial function in middle-aged and older adults: a systematic review and meta-analysis of randomized controlled trials"}, {"directness": "primary", "doi": "10.3389/fpubh.2024.1322437", "risk_of_bias": "not appraised in public sidecar", "study": "Relationship between addictions and obesity, physical activity and vascular aging in young adults (EVA-Adic study): a research protocol of a cross-sectional study"}, {"directness": "primary", "doi": "10.1097/HJH.0000000000004227", "risk_of_bias": "not appraised in public sidecar", "study": "Prevalence and determinants of vascular aging in Austria – a holistic view: the LEAD study"}, {"directness": "primary", "doi": "10.1111/acel.70503", "risk_of_bias": "not appraised in public sidecar", "study": "Estimating Vascular Age to Evaluate the Association Between Aging and Cardiovascular Disease"}, {"directness": "primary", "doi": "10.3390/jcm15114087", "risk_of_bias": "not appraised in public sidecar", "study": "Vascular Endothelial Function, Carotid Intima–Media Thickness and Coronary Artery Calcification in Women"}, {"directness": "primary", "doi": "10.1136/bmjopen-2024-097718", "risk_of_bias": "not appraised in public sidecar", "study": "Arterial stiffness in acute decompensated heart failure and acute kidney injury: a prospective observational cohort study protocol in a tertiary hospital setting"}, {"directness": "primary", "doi": "10.1161/JAHA.122.029466", "risk_of_bias": "not appraised in public sidecar", "study": "Arterial Age and Early Vascular Aging, But Not Chronological Age, Are Associated With Faster Thoracic Aortic Aneurysm Growth"}, {"directness": "review-level", "doi": "10.1530/VB-25-0004", "risk_of_bias": "not appraised in public sidecar", "study": "Methylarginine levels and their impact on vascular aging: a systematic review"}, {"directness": "review-level", "doi": "10.1038/s41371-024-00961-y", "risk_of_bias": "not appraised in public sidecar", "study": "Advanced vascular aging and outcomes after acute ischemic stroke: a systematic review and meta-analysis."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen."}, {"directness": "citation", "doi": "10.1001/jama.2010.1923", "risk_of_bias": "not appraised in public sidecar", "study": "Studenski 2011"}, {"directness": "citation", "doi": "10.1093/gerona/glp012", "risk_of_bias": "not appraised in public sidecar", "study": "Cesari 2009"}, {"directness": "citation", "doi": "10.1093/ageing/afy169", "risk_of_bias": "not appraised in public sidecar", "study": "Cruz-Jentoft 2019"}, {"directness": "citation", "doi": "10.1371/journal.pmed.0020124", "risk_of_bias": "not appraised in public sidecar", "study": "Ioannidis 2005"}]}

{
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  "researka_submission_id": "90a9d5a5-b7b5-4e2e-95d7-35d6a73bede3",
  "sidecar_name": "risk_of_bias.json",
  "sidecar_url": "https://api.researka.org/publications/d8e97ad6-d465-4e84-8231-2402678c670c/sidecars/risk_of_bias.json"
}