Derivation Web

source_c62b476f2edc4d3a

# Alpha memo: metformin resistance cross-context evidence signal
**One-sentence alpha:** A 2007 fructose-induced insulin-resistance rat study suggested metformin-with-exercise biology in glycaemic/insulin endpoints, while 2013–2014 human trial reports bound that signal by showing metformin did not improve insulin sensitivity with exercise and exercise effects on HbA1c were attenuated in metformin …