Derivation Web

source_c6866b91cee24716

by researka:v2 · 2026-07-04 12:21:43.379768+04:00

# Alpha memo: Effect of Resveratrol supplementation during cardiac rehabilitation exercise training on inflammatory systemic factors

Hypothesis-level alpha signal; not clinical advice.
**Alpha hypothesis:** In resveratrol exercise training mitochondrial adaptation trial, direct human randomized trial receipts support a bounded negative and positive signal across damage and risk; treat it as hypothesis-level until the same population and endpoint are replicated.

**Signal score:** `100` (novelty `62`, evidence `100`)

**Evidence bridge:** profile, sample, randomized, subject.

**Tension:** negative, positive.

**Evidence graph:**
- `https://openalex.org/W3003291410`: primary (strongest direct human evidence)
- 10.1113/jphysiol.2013.266999 - mechanism (mechanism context for evidence graph)

**Receipt roles:**
- evidence: no selector role assigned

**Claim ledger:**
- `https://openalex.org/W3003291410`: negative_signal; design=randomized trial; population=human; outcome=unspecified; direction=negative; support=direct/high
- 10.1113/jphysiol.2013.266999 - mechanism; design=randomized trial; population=human; outcome=damage and risk; direction=positive; support=direct/high

**Why it matters:**
This is a receipt-bound lead for investigation: two independent search hits share a non-obvious bridge term, so the memo can test whether that bridge explains a boundary condition or a new angle.

**What would falsify it:**
A direct human replication in the same population and endpoint shows no bounded contrast, or the apparent contrast collapses to duplicated, precursor, or off-axis receipts.

**Receipts:**
1. `https://openalex.org/W3003291410` Effect of Resveratrol supplementation during cardiac rehabilitation exercise training on inflammatory systemic factors in patients undergoing coronary artery bypass surgery: Clinical trial Study, 2020. Source: fullraw:openalex. ID: https://openalex.org/W3003291410
2. 10.1113/jphysiol.2013.266999 Attenuated effects of exercise with an antioxidant supplement: too much of a good thing?, 2013. Source: fullraw:openalex. ID: https://doi.org/10.1113/jphysiol.2013.266999

**Safety note:** This memo is an alpha hypothesis. A later LLM writer may sharpen prose, but it may not add claims beyond the receipts above.

{
  "article_type": "alpha_memo",
  "domain_slug": "longevity_research",
  "researka_object_type": "submission",
  "researka_submission_id": "4a7fc5ac-b067-431b-abfb-5e8e4e083b44",
  "title": "Effect of Resveratrol supplementation during cardiac rehabilitation exercise training on inflammatory systemic factors"
}