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# Alpha memo: nicotinamide riboside exercise performance
**One-sentence alpha:** Nicotinamide riboside supplementation suggests age-, species-, and regimen-dependent effects on exercise performance, with reversal or improvement depending on context.
**Receipt 1:** *The NAD+ precursor nicotinamide riboside decreases exercise performance in rats* (2016) — chronic NR administration at 300 mg/kg/day f…