Derivation Web

source_ca26fa0dfdba4988

by researka:v2 · 2026-06-26 10:16:07.101860+04:00

{"publication_id": "4a4ef105-6735-457c-a03e-c95da4a8e083", "traces": [{"candidate_sources": [{"doi": "10.1186/s13287-023-03359-8", "study": "Cartilage regeneration and inflammation modulation in knee osteoarthritis following injection of allogeneic adipose-derived mesenchymal stromal cells: a phase II, triple-blinded, placebo controlled, randomized trial", "url": "https://doi.org/10.1186/s13287-023-03359-8"}, {"doi": "10.1016/j.ebiom.2026.106268", "study": "Safety and efficacy of allogeneic umbilical cord-derived mesenchymal stem cell infusion for frailty: a phase 2, single-centre, randomised, open-label controlled trial", "url": "https://doi.org/10.1016/j.ebiom.2026.106268"}, {"doi": "10.1186/s13287-024-03746-9", "study": "A phase I/II clinical trial of ex-vivo expanded human bone marrow derived allogeneic mesenchymal stromal cells in adult patients with perianal fistulizing Crohn’s Disease", "url": "https://doi.org/10.1186/s13287-024-03746-9"}, {"doi": "10.1186/s13287-025-04577-y", "study": "Allogeneic bone marrow-derived mesenchymal stem cells in the aging kidney: secondary results of a Parkinson’s disease clinical trial", "url": "https://doi.org/10.1186/s13287-025-04577-y"}, {"doi": "10.1007/s12015-024-10696-5", "study": "Bone Regeneration with Mesenchymal Stem Cells in Scaffolds: Systematic Review of Human Clinical Trials", "url": "https://doi.org/10.1007/s12015-024-10696-5"}], "claim": "This paper synthesizes evidence on Mesenchymal stem cells across 16 accepted source papers and 1156 high-confidence extracted claims.", "claim_id": "claim_1"}, {"candidate_sources": [{"doi": "10.1186/s13287-023-03359-8", "study": "Cartilage regeneration and inflammation modulation in knee osteoarthritis following injection of allogeneic adipose-derived mesenchymal stromal cells: a phase II, triple-blinded, placebo controlled, randomized trial", "url": "https://doi.org/10.1186/s13287-023-03359-8"}, {"doi": "10.1016/j.ebiom.2026.106268", "study": "Safety and efficacy of allogeneic umbilical cord-derived mesenchymal stem cell infusion for frailty: a phase 2, single-centre, randomised, open-label controlled trial", "url": "https://doi.org/10.1016/j.ebiom.2026.106268"}, {"doi": "10.1186/s13287-024-03746-9", "study": "A phase I/II clinical trial of ex-vivo expanded human bone marrow derived allogeneic mesenchymal stromal cells in adult patients with perianal fistulizing Crohn’s Disease", "url": "https://doi.org/10.1186/s13287-024-03746-9"}, {"doi": "10.1186/s13287-025-04577-y", "study": "Allogeneic bone marrow-derived mesenchymal stem cells in the aging kidney: secondary results of a Parkinson’s disease clinical trial", "url": "https://doi.org/10.1186/s13287-025-04577-y"}, {"doi": "10.1007/s12015-024-10696-5", "study": "Bone Regeneration with Mesenchymal Stem Cells in Scaffolds: Systematic Review of Human Clinical Trials", "url": "https://doi.org/10.1007/s12015-024-10696-5"}], "claim": "The evidence profile contains 2 direct clinical sources, 14 adjacent clinical sources, and no sources classified primarily as mechanistic or model-system evidence, with 30 cross-study disagreements across the evidence base.", "claim_id": "claim_2"}, {"candidate_sources": [{"doi": "10.1186/s13287-023-03359-8", "study": "Cartilage regeneration and inflammation modulation in knee osteoarthritis following injection of allogeneic adipose-derived mesenchymal stromal cells: a phase II, triple-blinded, placebo controlled, randomized trial", "url": "https://doi.org/10.1186/s13287-023-03359-8"}, {"doi": "10.1016/j.ebiom.2026.106268", "study": "Safety and efficacy of allogeneic umbilical cord-derived mesenchymal stem cell infusion for frailty: a phase 2, single-centre, randomised, open-label controlled trial", "url": "https://doi.org/10.1016/j.ebiom.2026.106268"}, {"doi": "10.1186/s13287-024-03746-9", "study": "A phase I/II clinical trial of ex-vivo expanded human bone marrow derived allogeneic mesenchymal stromal cells in adult patients with perianal fistulizing Crohn’s Disease", "url": "https://doi.org/10.1186/s13287-024-03746-9"}, {"doi": "10.1186/s13287-025-04577-y", "study": "Allogeneic bone marrow-derived mesenchymal stem cells in the aging kidney: secondary results of a Parkinson’s disease clinical trial", "url": "https://doi.org/10.1186/s13287-025-04577-y"}, {"doi": "10.1007/s12015-024-10696-5", "study": "Bone Regeneration with Mesenchymal Stem Cells in Scaffolds: Systematic Review of Human Clinical Trials", "url": "https://doi.org/10.1007/s12015-024-10696-5"}], "claim": "Positive study-level signals are summarized in the immune and inflammation, safety and comorbidity outcome classes, null signals in the safety and comorbidity, contextual adjacent evidence, safety outcome classes, and negative signals in the contextual adjacent evidence outcome class. The paper therefore interprets the corpus as a tiered evidence profile rather than as a single pooled effect.", "claim_id": "claim_3"}, {"candidate_sources": [{"doi": "10.1186/s13287-023-03359-8", "study": "Cartilage regeneration and inflammation modulation in knee osteoarthritis following injection of allogeneic adipose-derived mesenchymal stromal cells: a phase II, triple-blinded, placebo controlled, randomized trial", "url": "https://doi.org/10.1186/s13287-023-03359-8"}, {"doi": "10.1016/j.ebiom.2026.106268", "study": "Safety and efficacy of allogeneic umbilical cord-derived mesenchymal stem cell infusion for frailty: a phase 2, single-centre, randomised, open-label controlled trial", "url": "https://doi.org/10.1016/j.ebiom.2026.106268"}, {"doi": "10.1186/s13287-024-03746-9", "study": "A phase I/II clinical trial of ex-vivo expanded human bone marrow derived allogeneic mesenchymal stromal cells in adult patients with perianal fistulizing Crohn’s Disease", "url": "https://doi.org/10.1186/s13287-024-03746-9"}, {"doi": "10.1186/s13287-025-04577-y", "study": "Allogeneic bone marrow-derived mesenchymal stem cells in the aging kidney: secondary results of a Parkinson’s disease clinical trial", "url": "https://doi.org/10.1186/s13287-025-04577-y"}, {"doi": "10.1007/s12015-024-10696-5", "study": "Bone Regeneration with Mesenchymal Stem Cells in Scaffolds: Systematic Review of Human Clinical Trials", "url": "https://doi.org/10.1007/s12015-024-10696-5"}], "claim": "The conclusion is that Mesenchymal stem cells remains a bounded geroscience case: the retained clinical and adjacent evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.", "claim_id": "claim_4"}, {"candidate_sources": [{"doi": "10.1186/s13287-023-03359-8", "study": "Cartilage regeneration and inflammation modulation in knee osteoarthritis following injection of allogeneic adipose-derived mesenchymal stromal cells: a phase II, triple-blinded, placebo controlled, randomized trial", "url": "https://doi.org/10.1186/s13287-023-03359-8"}, {"doi": "10.1016/j.ebiom.2026.106268", "study": "Safety and efficacy of allogeneic umbilical cord-derived mesenchymal stem cell infusion for frailty: a phase 2, single-centre, randomised, open-label controlled trial", "url": "https://doi.org/10.1016/j.ebiom.2026.106268"}, {"doi": "10.1186/s13287-024-03746-9", "study": "A phase I/II clinical trial of ex-vivo expanded human bone marrow derived allogeneic mesenchymal stromal cells in adult patients with perianal fistulizing Crohn’s Disease", "url": "https://doi.org/10.1186/s13287-024-03746-9"}, {"doi": "10.1186/s13287-025-04577-y", "study": "Allogeneic bone marrow-derived mesenchymal stem cells in the aging kidney: secondary results of a Parkinson’s disease clinical trial", "url": "https://doi.org/10.1186/s13287-025-04577-y"}, {"doi": "10.1007/s12015-024-10696-5", "study": "Bone Regeneration with Mesenchymal Stem Cells in Scaffolds: Systematic Review of Human Clinical Trials", "url": "https://doi.org/10.1007/s12015-024-10696-5"}], "claim": "For that reason, the manuscript does not collapse every source into a single recommendation. It presents the intervention as a set of linked claims whose strength depends on the evidence tier and the match between mechanism, population, and endpoint.", "claim_id": "claim_5"}, {"candidate_sources": [{"doi": "10.1186/s13287-023-03359-8", "study": "Cartilage regeneration and inflammation modulation in knee osteoarthritis following injection of allogeneic adipose-derived mesenchymal stromal cells: a phase II, triple-blinded, placebo controlled, randomized trial", "url": "https://doi.org/10.1186/s13287-023-03359-8"}, {"doi": "10.1016/j.ebiom.2026.106268", "study": "Safety and efficacy of allogeneic umbilical cord-derived mesenchymal stem cell infusion for frailty: a phase 2, single-centre, randomised, open-label controlled trial", "url": "https://doi.org/10.1016/j.ebiom.2026.106268"}, {"doi": "10.1186/s13287-024-03746-9", "study": "A phase I/II clinical trial of ex-vivo expanded human bone marrow derived allogeneic mesenchymal stromal cells in adult patients with perianal fistulizing Crohn’s Disease", "url": "https://doi.org/10.1186/s13287-024-03746-9"}, {"doi": "10.1186/s13287-025-04577-y", "study": "Allogeneic bone marrow-derived mesenchymal stem cells in the aging kidney: secondary results of a Parkinson’s disease clinical trial", "url": "https://doi.org/10.1186/s13287-025-04577-y"}, {"doi": "10.1007/s12015-024-10696-5", "study": "Bone Regeneration with Mesenchymal Stem Cells in Scaffolds: Systematic Review of Human Clinical Trials", "url": "https://doi.org/10.1007/s12015-024-10696-5"}], "claim": "Mesenchymal stromal cells (MSCs) — broadly defined as adult stromal cells with multi-lineage differentiation capacity and paracrine immunomodulatory activity — have been proposed as a regenerative cell therapy with mechanism-level plausibility across several aging-relevant pathways. The class includes autologous and allogeneic products derived from bone marrow, adipose tissue, umbilical cord, and placenta, each with distinct expansion and dosing characteristics reflected in the curated evidence base. Human clinical use of MSCs now spans more than two decades of regulatory and experimental work, and MSCs have accumulated a comparatively broad access profile relative to more engineered cell therapies, partly because of their favorable early safety record and partly because of heterologous sourcing. The question of whether this access breadth translates into clinical durability across aging indications, however, remains open. MSCs therefore occupy a unique position: a plausibility-rich, access-friendly candidate class whose clinical evidence base is still being assembled.", "claim_id": "claim_6"}, {"candidate_sources": [{"doi": "10.1186/s13287-023-03359-8", "study": "Cartilage regeneration and inflammation modulation in knee osteoarthritis following injection of allogeneic adipose-derived mesenchymal stromal cells: a phase II, triple-blinded, placebo controlled, randomized trial", "url": "https://doi.org/10.1186/s13287-023-03359-8"}, {"doi": "10.1016/j.ebiom.2026.106268", "study": "Safety and efficacy of allogeneic umbilical cord-derived mesenchymal stem cell infusion for frailty: a phase 2, single-centre, randomised, open-label controlled trial", "url": "https://doi.org/10.1016/j.ebiom.2026.106268"}, {"doi": "10.1186/s13287-024-03746-9", "study": "A phase I/II clinical trial of ex-vivo expanded human bone marrow derived allogeneic mesenchymal stromal cells in adult patients with perianal fistulizing Crohn’s Disease", "url": "https://doi.org/10.1186/s13287-024-03746-9"}, {"doi": "10.1186/s13287-025-04577-y", "study": "Allogeneic bone marrow-derived mesenchymal stem cells in the aging kidney: secondary results of a Parkinson’s disease clinical trial", "url": "https://doi.org/10.1186/s13287-025-04577-y"}, {"doi": "10.1007/s12015-024-10696-5", "study": "Bone Regeneration with Mesenchymal Stem Cells in Scaffolds: Systematic Review of Human Clinical Trials", "url": "https://doi.org/10.1007/s12015-024-10696-5"}], "claim": "Several unresolved questions shape how the Mesenchymal evidence base should be interpreted. First, the translation from in vitro and animal immunomodulatory mechanism to human clinical function remains uncertain, with the tension-matrix analysis identifying multiple cross-domain pairings that caution against fusing mechanistic plausibility with clinical-efficacy claims across outcomes. Second, MSCs appear to carry population-specific tradeoffs — dose, route, and source likely interact with baseline frailty and comorbidity, as suggested by the Sartika 2026 dose-and-delivery synthesis — yet these modifiers are rarely tested head-to-head. Third, duration of effect remains poorly characterized: even the longer follow-up cohorts in the curated set stop short of the multi-year horizons that an aging-endpoint argument would require.", "claim_id": "claim_7"}, {"candidate_sources": [{"doi": "10.1186/s13287-023-03359-8", "study": "Cartilage regeneration and inflammation modulation in knee osteoarthritis following injection of allogeneic adipose-derived mesenchymal stromal cells: a phase II, triple-blinded, placebo controlled, randomized trial", "url": "https://doi.org/10.1186/s13287-023-03359-8"}, {"doi": "10.1016/j.ebiom.2026.106268", "study": "Safety and efficacy of allogeneic umbilical cord-derived mesenchymal stem cell infusion for frailty: a phase 2, single-centre, randomised, open-label controlled trial", "url": "https://doi.org/10.1016/j.ebiom.2026.106268"}, {"doi": "10.1186/s13287-024-03746-9", "study": "A phase I/II clinical trial of ex-vivo expanded human bone marrow derived allogeneic mesenchymal stromal cells in adult patients with perianal fistulizing Crohn’s Disease", "url": "https://doi.org/10.1186/s13287-024-03746-9"}, {"doi": "10.1186/s13287-025-04577-y", "study": "Allogeneic bone marrow-derived mesenchymal stem cells in the aging kidney: secondary results of a Parkinson’s disease clinical trial", "url": "https://doi.org/10.1186/s13287-025-04577-y"}, {"doi": "10.1007/s12015-024-10696-5", "study": "Bone Regeneration with Mesenchymal Stem Cells in Scaffolds: Systematic Review of Human Clinical Trials", "url": "https://doi.org/10.1007/s12015-024-10696-5"}], "claim": "This synthesis takes a structured-evidence approach: rather than narratively averaging positive and negative findings, it weights studies by directness to the aging question, separates mechanistic signals from clinical-outcome signals, and surfaces the cross-study disagreements identified across outcome classes. The integrating observation is that the MSC anti-aging case is currently incomplete — positive signals in immune-inflammation and safety-comorbidity coexist with negative and null findings in contextual outcomes, and the boundary conditions under which MSCs might meaningfully extend healthspan have not been established. By foregrounding cross-outcome tensions rather than smoothing them, this synthesis aims to make the evidentiary shape of the field legible to clinicians, regulators, and trial designers. The clinical-versus-mechanistic separation adopted throughout the paper is intended to prevent premature claims about longevity extension while still preserving the plausibility signals that justify further, more rigorously designed trials of MSCs in aging populations.", "claim_id": "claim_8"}, {"candidate_sources": [{"doi": "10.1186/s13287-023-03359-8", "study": "Cartilage regeneration and inflammation modulation in knee osteoarthritis following injection of allogeneic adipose-derived mesenchymal stromal cells: a phase II, triple-blinded, placebo controlled, randomized trial", "url": "https://doi.org/10.1186/s13287-023-03359-8"}, {"doi": "10.1016/j.ebiom.2026.106268", "study": "Safety and efficacy of allogeneic umbilical cord-derived mesenchymal stem cell infusion for frailty: a phase 2, single-centre, randomised, open-label controlled trial", "url": "https://doi.org/10.1016/j.ebiom.2026.106268"}, {"doi": "10.1186/s13287-024-03746-9", "study": "A phase I/II clinical trial of ex-vivo expanded human bone marrow derived allogeneic mesenchymal stromal cells in adult patients with perianal fistulizing Crohn’s Disease", "url": "https://doi.org/10.1186/s13287-024-03746-9"}, {"doi": "10.1186/s13287-025-04577-y", "study": "Allogeneic bone marrow-derived mesenchymal stem cells in the aging kidney: secondary results of a Parkinson’s disease clinical trial", "url": "https://doi.org/10.1186/s13287-025-04577-y"}, {"doi": "10.1007/s12015-024-10696-5", "study": "Bone Regeneration with Mesenchymal Stem Cells in Scaffolds: Systematic Review of Human Clinical Trials", "url": "https://doi.org/10.1007/s12015-024-10696-5"}], "claim": "The background evidence for Mesenchymal stem cells is heterogeneous rather than uniformly confirmatory. Direct clinical sources such as Sadri 2023, Nguyen 2026 are interpreted separately from mechanistic studies such as the retained evidence base, because these evidence roles answer different questions about aging biology and clinical translation.", "claim_id": "claim_9"}, {"candidate_sources": [{"doi": "10.1186/s13287-023-03359-8", "study": "Cartilage regeneration and inflammation modulation in knee osteoarthritis following injection of allogeneic adipose-derived mesenchymal stromal cells: a phase II, triple-blinded, placebo controlled, randomized trial", "url": "https://doi.org/10.1186/s13287-023-03359-8"}, {"doi": "10.1016/j.ebiom.2026.106268", "study": "Safety and efficacy of allogeneic umbilical cord-derived mesenchymal stem cell infusion for frailty: a phase 2, single-centre, randomised, open-label controlled trial", "url": "https://doi.org/10.1016/j.ebiom.2026.106268"}, {"doi": "10.1186/s13287-024-03746-9", "study": "A phase I/II clinical trial of ex-vivo expanded human bone marrow derived allogeneic mesenchymal stromal cells in adult patients with perianal fistulizing Crohn’s Disease", "url": "https://doi.org/10.1186/s13287-024-03746-9"}, {"doi": "10.1186/s13287-025-04577-y", "study": "Allogeneic bone marrow-derived mesenchymal stem cells in the aging kidney: secondary results of a Parkinson’s disease clinical trial", "url": "https://doi.org/10.1186/s13287-025-04577-y"}, {"doi": "10.1007/s12015-024-10696-5", "study": "Bone Regeneration with Mesenchymal Stem Cells in Scaffolds: Systematic Review of Human Clinical Trials", "url": "https://doi.org/10.1007/s12015-024-10696-5"}], "claim": "The direct evidence establishes what has been observed in human or adjacent clinical settings. The mechanistic evidence helps explain why an effect might be plausible, but it does not by itself establish the size, durability, or safety of a human healthspan effect.", "claim_id": "claim_10"}, {"candidate_sources": [{"doi": "10.1186/s13287-023-03359-8", "study": "Cartilage regeneration and inflammation modulation in knee osteoarthritis following injection of allogeneic adipose-derived mesenchymal stromal cells: a phase II, triple-blinded, placebo controlled, randomized trial", "url": "https://doi.org/10.1186/s13287-023-03359-8"}, {"doi": "10.1016/j.ebiom.2026.106268", "study": "Safety and efficacy of allogeneic umbilical cord-derived mesenchymal stem cell infusion for frailty: a phase 2, single-centre, randomised, open-label controlled trial", "url": "https://doi.org/10.1016/j.ebiom.2026.106268"}, {"doi": "10.1186/s13287-024-03746-9", "study": "A phase I/II clinical trial of ex-vivo expanded human bone marrow derived allogeneic mesenchymal stromal cells in adult patients with perianal fistulizing Crohn’s Disease", "url": "https://doi.org/10.1186/s13287-024-03746-9"}, {"doi": "10.1186/s13287-025-04577-y", "study": "Allogeneic bone marrow-derived mesenchymal stem cells in the aging kidney: secondary results of a Parkinson’s disease clinical trial", "url": "https://doi.org/10.1186/s13287-025-04577-y"}, {"doi": "10.1007/s12015-024-10696-5", "study": "Bone Regeneration with Mesenchymal Stem Cells in Scaffolds: Systematic Review of Human Clinical Trials", "url": "https://doi.org/10.1007/s12015-024-10696-5"}], "claim": "Across the retained sources, positive signals cluster around the immune and inflammation, safety and comorbidity outcome classes; null signals around the safety and comorbidity, contextual adjacent evidence, safety outcome classes; and negative or adverse signals around the contextual adjacent evidence outcome class. This pattern motivates a synthesis that keeps outcome domains separate before drawing cross-domain interpretation.", "claim_id": "claim_11"}, {"candidate_sources": [{"doi": "10.1186/s13287-023-03359-8", "study": "Cartilage regeneration and inflammation modulation in knee osteoarthritis following injection of allogeneic adipose-derived mesenchymal stromal cells: a phase II, triple-blinded, placebo controlled, randomized trial", "url": "https://doi.org/10.1186/s13287-023-03359-8"}, {"doi": "10.1016/j.ebiom.2026.106268", "study": "Safety and efficacy of allogeneic umbilical cord-derived mesenchymal stem cell infusion for frailty: a phase 2, single-centre, randomised, open-label controlled trial", "url": "https://doi.org/10.1016/j.ebiom.2026.106268"}, {"doi": "10.1186/s13287-024-03746-9", "study": "A phase I/II clinical trial of ex-vivo expanded human bone marrow derived allogeneic mesenchymal stromal cells in adult patients with perianal fistulizing Crohn’s Disease", "url": "https://doi.org/10.1186/s13287-024-03746-9"}, {"doi": "10.1186/s13287-025-04577-y", "study": "Allogeneic bone marrow-derived mesenchymal stem cells in the aging kidney: secondary results of a Parkinson’s disease clinical trial", "url": "https://doi.org/10.1186/s13287-025-04577-y"}, {"doi": "10.1007/s12015-024-10696-5", "study": "Bone Regeneration with Mesenchymal Stem Cells in Scaffolds: Systematic Review of Human Clinical Trials", "url": "https://doi.org/10.1007/s12015-024-10696-5"}], "claim": "The study-level structure also prevents selective emphasis. Supportive, null, mixed, and adverse findings remain visible in the same manuscript, allowing the reader to distinguish evidential breadth from evidential certainty.", "claim_id": "claim_12"}, {"candidate_sources": [{"doi": "10.1186/s13287-023-03359-8", "study": "Cartilage regeneration and inflammation modulation in knee osteoarthritis following injection of allogeneic adipose-derived mesenchymal stromal cells: a phase II, triple-blinded, placebo controlled, randomized trial", "url": "https://doi.org/10.1186/s13287-023-03359-8"}, {"doi": "10.1016/j.ebiom.2026.106268", "study": "Safety and efficacy of allogeneic umbilical cord-derived mesenchymal stem cell infusion for frailty: a phase 2, single-centre, randomised, open-label controlled trial", "url": "https://doi.org/10.1016/j.ebiom.2026.106268"}, {"doi": "10.1186/s13287-024-03746-9", "study": "A phase I/II clinical trial of ex-vivo expanded human bone marrow derived allogeneic mesenchymal stromal cells in adult patients with perianal fistulizing Crohn’s Disease", "url": "https://doi.org/10.1186/s13287-024-03746-9"}, {"doi": "10.1186/s13287-025-04577-y", "study": "Allogeneic bone marrow-derived mesenchymal stem cells in the aging kidney: secondary results of a Parkinson’s disease clinical trial", "url": "https://doi.org/10.1186/s13287-025-04577-y"}, {"doi": "10.1007/s12015-024-10696-5", "study": "Bone Regeneration with Mesenchymal Stem Cells in Scaffolds: Systematic Review of Human Clinical Trials", "url": "https://doi.org/10.1007/s12015-024-10696-5"}], "claim": "The resulting paper is therefore a calibrated synthesis: it can identify plausible mechanisms, observed direct signals when present, unresolved tensions, and trial-design priorities without converting them into claims stronger than the retained corpus can support.", "claim_id": "claim_13"}, {"candidate_sources": [{"doi": "10.1186/s13287-023-03359-8", "study": "Cartilage regeneration and inflammation modulation in knee osteoarthritis following injection of allogeneic adipose-derived mesenchymal stromal cells: a phase II, triple-blinded, placebo controlled, randomized trial", "url": "https://doi.org/10.1186/s13287-023-03359-8"}, {"doi": "10.1016/j.ebiom.2026.106268", "study": "Safety and efficacy of allogeneic umbilical cord-derived mesenchymal stem cell infusion for frailty: a phase 2, single-centre, randomised, open-label controlled trial", "url": "https://doi.org/10.1016/j.ebiom.2026.106268"}, {"doi": "10.1186/s13287-024-03746-9", "study": "A phase I/II clinical trial of ex-vivo expanded human bone marrow derived allogeneic mesenchymal stromal cells in adult patients with perianal fistulizing Crohn’s Disease", "url": "https://doi.org/10.1186/s13287-024-03746-9"}, {"doi": "10.1186/s13287-025-04577-y", "study": "Allogeneic bone marrow-derived mesenchymal stem cells in the aging kidney: secondary results of a Parkinson’s disease clinical trial", "url": "https://doi.org/10.1186/s13287-025-04577-y"}, {"doi": "10.1007/s12015-024-10696-5", "study": "Bone Regeneration with Mesenchymal Stem Cells in Scaffolds: Systematic Review of Human Clinical Trials", "url": "https://doi.org/10.1007/s12015-024-10696-5"}], "claim": "The following fields were extracted from each included source: study design, population / cohort, intervention or exposure, comparator, outcome class, effect direction, effect size, confidence interval or credible interval, p-value, sample size, follow-up duration, risk-of-bias rating. Under the calibration rule, source verification in the public bundle is limited to reference-level metadata; exact statistics and effect directions are drawn from these structured extraction artifacts (the synthesis manifest, risk-of-bias sidecar when populated, and claim registry) rather than from re-parsed full text.", "claim_id": "claim_14"}, {"candidate_sources": [{"doi": "10.1186/s13287-023-03359-8", "study": "Cartilage regeneration and inflammation modulation in knee osteoarthritis following injection of allogeneic adipose-derived mesenchymal stromal cells: a phase II, triple-blinded, placebo controlled, randomized trial", "url": "https://doi.org/10.1186/s13287-023-03359-8"}, {"doi": "10.1016/j.ebiom.2026.106268", "study": "Safety and efficacy of allogeneic umbilical cord-derived mesenchymal stem cell infusion for frailty: a phase 2, single-centre, randomised, open-label controlled trial", "url": "https://doi.org/10.1016/j.ebiom.2026.106268"}, {"doi": "10.1186/s13287-024-03746-9", "study": "A phase I/II clinical trial of ex-vivo expanded human bone marrow derived allogeneic mesenchymal stromal cells in adult patients with perianal fistulizing Crohn’s Disease", "url": "https://doi.org/10.1186/s13287-024-03746-9"}, {"doi": "10.1186/s13287-025-04577-y", "study": "Allogeneic bone marrow-derived mesenchymal stem cells in the aging kidney: secondary results of a Parkinson’s disease clinical trial", "url": "https://doi.org/10.1186/s13287-025-04577-y"}, {"doi": "10.1007/s12015-024-10696-5", "study": "Bone Regeneration with Mesenchymal Stem Cells in Scaffolds: Systematic Review of Human Clinical Trials", "url": "https://doi.org/10.1007/s12015-024-10696-5"}], "claim": "Risk-of-bias framework assignment follows study design (RoB-2 for RCTs, ROBINS-I for non-randomised studies, AMSTAR-2 for systematic reviews / meta-analyses). 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