Derivation Web

source_cba7c2560e6f4fb0

by researka:v2 · 2026-06-25 09:50:22.823326+04:00

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Grouped by direction: directionally favorable: 1 receipt(s) | other/mixed: 4 receipt(s). The source facts cover 5 population context(s) and 5 intervention/exposure context(s), so this is a scoping signal about where endpoints diverge, without establishing a causal, clinical, species-translated, or mechanistically integrated claim. The listed effect sizes remain source-specific across endpoints and populations; they are not pooled or averaged. This is a heterogeneous indication/context map, not a unified disease-specific or endpoint-family claim. Concrete source-level examples: Interventions involving resistance training and caloric restriction were the most effective for reducing body fat percentage; RT+CR+AT produced significantly greater increases in leg muscle strength [4.9 (0.7, 9.0) versus –1.1 (–5.5, 3.2) Nm, P =0.05]; RT reduced 93.5% of CR-induced LBM loss.", "type": "claim"}, {"id": "claim_4", "text": "null/non-convergent or other/mixed: the extracted fact is null, mixed, or not directionally interpretable.", "type": "claim"}, {"id": "claim_5", "text": "other/mixed: A Randomized, Controlled Trial of Resistance Training Added to Caloric Restriction Plus Aerobic Exercise Training in Obese Heart Failure With Preserved Ejection Fraction — RT+CR+AT produced significantly greater increases in leg muscle strength [4.9 (0.7, 9.0) versus –1.1 (–5.5, 3.2) Nm, P =0.05]", "type": "claim"}, {"id": "claim_6", "text": "Specific moderators in this bundle are population/indication (adults without obesity; free-living adults with overweight/obesity; individuals with overweight and obesity; obese elderly individuals; older patients with obese heart failure with preserved ejection fraction), study design/evidence type (primary/review). Single primary-study estimates are separated from pooled review or meta-analytic estimates rather than treated as interchangeable.", "type": "claim"}, {"id": "claim_7", "text": "The selected receipts group because each carries a fact-level extraction for caloric_restriction; they separate by context (human clinical/observational and other source context) and endpoint, so they are not interchangeable evidence for one pooled claim.", "type": "claim"}, {"id": "claim_8", "text": "The signal is purely descriptive of effect-direction heterogeneity; it cannot support even a weak causal or comparative-efficacy inference, and pooling across these PICOs would be inappropriate.", "type": "claim"}, {"comparator": "not extracted", "directness": "review-level", "doi": "10.1111/obr.13428", "effect": "not extracted", "endpoint": "not extracted", "id": "source_1", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Resistance training effectiveness on body composition and body weight outcomes in individuals with overweight and obesity across the lifespan: A systematic review and meta‐analysis", "type": "source", "url": "https://doi.org/10.1111/obr.13428", "year": 2022}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1161/circheartfailure.122.010161", "effect": "not extracted", "endpoint": "not extracted", "id": "source_2", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "A Randomized, Controlled Trial of Resistance Training Added to Caloric Restriction Plus Aerobic Exercise Training in Obese Heart Failure With Preserved Ejection Fraction", "type": "source", "url": "https://doi.org/10.1161/circheartfailure.122.010161", "year": 2022}, {"comparator": "not extracted", "directness": "review-level", "doi": "10.3390/nu10040423", "effect": "not extracted", "endpoint": "not extracted", "id": "source_3", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Resistance Training Prevents Muscle Loss Induced by Caloric Restriction in Obese Elderly Individuals: A Systematic Review and Meta-Analysis", "type": "source", "url": "https://doi.org/10.3390/nu10040423", "year": 2018}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1038/s41467-024-48355-5", "effect": "not extracted", "endpoint": "not extracted", "id": "source_4", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Gut microbiome remodeling and metabolomic profile improves in response to protein pacing with intermittent fasting versus continuous caloric restriction", "type": "source", "url": "https://doi.org/10.1038/s41467-024-48355-5", "year": 2024}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1038/s43587-022-00357-y", "effect": "not extracted", "endpoint": "not extracted", "id": "source_5", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial", "type": "source", "url": "https://doi.org/10.1038/s43587-022-00357-y", "year": 2023}], "publication_id": "03c60412-d58e-42e5-8c1a-1f2401559bcd", "screening": {"excluded": 0, "exclusion_reasons": ["No PRISMA full-text exclusion-stage filter was applied."], "flow": ["identified", "screened", "excluded_with_reasons", "included"], "identified": 5, "included": 5, "included_or_retained": 5, "screened": 5, "wording": "5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit."}}

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