Derivation Web

source_cbd9a39adec547ce

by researka:v2 · 2026-06-28 01:18:05.372572+04:00

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "124c3917-ffdc-4ae1-840c-cb71641cccd7", "sources": [{"directness": "primary", "doi": "10.1038/s41598-025-04873-w", "risk_of_bias": "not appraised in public sidecar", "study": "Photobiomodulation therapy for diabetic erectile dysfunction targeting neuroinflammation and neurovascular regeneration"}, {"directness": "review-level", "doi": "10.3389/fmed.2025.1640403", "risk_of_bias": "not appraised in public sidecar", "study": "Effects of repeated low-level red light therapy on myopia progression in children: a systematic review and meta-analysis"}, {"directness": "primary", "doi": "10.1111/srt.13391", "risk_of_bias": "not appraised in public sidecar", "study": "Reverse skin aging signs by red light photobiomodulation"}, {"directness": "primary", "doi": "10.3390/nu17213357", "risk_of_bias": "not appraised in public sidecar", "study": "Photobiomodulation Acutely Augments Resting Metabolism in Women with Obesity"}, {"directness": "primary", "doi": "10.3390/jcm13237101", "risk_of_bias": "not appraised in public sidecar", "study": "The Efficacy of Multiwavelength Red and Near-Infrared Transdermal Photobiomodulation Light Therapy in Enhancing Female Fertility Outcomes and Improving Reproductive Health: A Prospective Case Series with 9-Month Follow-Up"}, {"directness": "primary", "doi": "10.3389/fneur.2025.1634701", "risk_of_bias": "not appraised in public sidecar", "study": "Red-light photobiomodulation improves cognition and neuropsychiatric symptoms in post-stroke cognitive impairment: a randomized trial"}, {"directness": "primary", "doi": "10.3390/biomedicines9030274", "risk_of_bias": "not appraised in public sidecar", "study": "Experimental and Clinical Applications of Red and Near-Infrared Photobiomodulation on Endothelial Dysfunction: A Review"}, {"directness": "primary", "doi": "10.1096/fj.202502477R", "risk_of_bias": "not appraised in public sidecar", "study": "Shining a Light on Skeletal Muscle Regeneration: Red Photobiomodulation Boosts Myoblast Differentiation In Vitro"}, {"directness": "primary", "doi": "10.7759/cureus.103274", "risk_of_bias": "not appraised in public sidecar", "study": "At-Home Red Light Therapy Devices: Promotion and Recommendation Patterns on Social Media in the Context of Limited Evidence"}, {"directness": "review-level", "doi": "10.4103/IJO.IJO_1037_23", "risk_of_bias": "not appraised in public sidecar", "study": "A meta-analysis of randomized controlled trials evaluating the effectiveness and safety of the repeated low-level red light therapy in slowing the progression of myopia in children and adolescents"}, {"directness": "primary", "doi": "10.1007/s10439-023-03384-x", "risk_of_bias": "not appraised in public sidecar", "study": "Photobiomodulation and Wound Healing: Low-Level Laser Therapy at 661 nm in a Scratch Assay Keratinocyte Model"}, {"directness": "primary", "doi": "10.1038/s41598-024-81363-5", "risk_of_bias": "not appraised in public sidecar", "study": "Synergistic effect of defocus incorporated multiple segment glasses and repeated low level red light therapy against myopia progression"}, {"directness": "primary", "doi": "10.1371/journal.pone.0326881", "risk_of_bias": "not appraised in public sidecar", "study": "Transcranial photobiomodulation therapy with 808 nm light changes expression of genes and proteins associated with neuroprotection, neuroinflammation, oxidative stress, and Alzheimer’s disease: Whole RNA sequencing of mouse cortex and hippocampus"}, {"directness": "primary", "doi": "10.1007/s10103-024-04042-x", "risk_of_bias": "not appraised in public sidecar", "study": "The effect of combined red, blue, and near-infrared light-emitting diode (LED) photobiomodulation therapy on speed of wound healing after superficial ablative fractional resurfacing"}, {"directness": "primary", "doi": "10.1002/alz.093626", "risk_of_bias": "not appraised in public sidecar", "study": "Red Light Therapy Attenuates Prolonged LED light Exposure‐Associated Neuropathology and Mediates Circadian Clock Genes ‐ Per1 and Bmal1 Expression in Rats' Basal Ganglia"}, {"directness": "review-level", "doi": "10.7759/cureus.104721", "risk_of_bias": "not appraised in public sidecar", "study": "Mechanistic Insights Into Photobiomodulation for Primary Dysmenorrhea: A Narrative Review"}, {"directness": "primary", "doi": "10.1089/photob.2020.4978", "risk_of_bias": "not appraised in public sidecar", "study": "Effect of Red-to-Near Infrared Light and a Nitric Oxide Donor on the Oxygen Consumption of Isolated Cytochrome c Oxidase"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen."}]}

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