source · application/json
source_cfbb3e5da93e4d98
sha256 837b8972f450a8276379cc53090f020289b17e82ef40b9c218b165252fa362de
by researka:v2 · 2026-05-28 07:55:06.841927+04:00
{"content_hash": null, "edges": [{"from": "ff0598d5-47d1-45bf-91bb-ff8e74948493", "to": "claim_1", "type": "contains_claim"}, {"from": "ff0598d5-47d1-45bf-91bb-ff8e74948493", "to": "claim_2", "type": "contains_claim"}, {"from": "ff0598d5-47d1-45bf-91bb-ff8e74948493", "to": "claim_3", "type": "contains_claim"}, {"from": "ff0598d5-47d1-45bf-91bb-ff8e74948493", "to": "claim_4", "type": "contains_claim"}, {"from": "ff0598d5-47d1-45bf-91bb-ff8e74948493", "to": "claim_5", "type": "contains_claim"}, {"from": "ff0598d5-47d1-45bf-91bb-ff8e74948493", "to": "claim_6", "type": "contains_claim"}, {"from": "ff0598d5-47d1-45bf-91bb-ff8e74948493", "to": "claim_7", "type": "contains_claim"}, {"from": "ff0598d5-47d1-45bf-91bb-ff8e74948493", "to": "claim_8", "type": "contains_claim"}, {"from": "ff0598d5-47d1-45bf-91bb-ff8e74948493", "to": "claim_9", "type": "contains_claim"}, {"from": "ff0598d5-47d1-45bf-91bb-ff8e74948493", "to": "claim_10", "type": "contains_claim"}, {"from": "ff0598d5-47d1-45bf-91bb-ff8e74948493", "to": "claim_11", "type": "contains_claim"}, {"from": "ff0598d5-47d1-45bf-91bb-ff8e74948493", "to": "claim_12", "type": "contains_claim"}, {"from": "ff0598d5-47d1-45bf-91bb-ff8e74948493", "to": "claim_13", "type": "contains_claim"}, {"from": "ff0598d5-47d1-45bf-91bb-ff8e74948493", "to": "claim_14", "type": "contains_claim"}, {"from": "ff0598d5-47d1-45bf-91bb-ff8e74948493", "to": "claim_15", "type": "contains_claim"}, {"from": "ff0598d5-47d1-45bf-91bb-ff8e74948493", "to": "claim_16", "type": "contains_claim"}, {"from": "ff0598d5-47d1-45bf-91bb-ff8e74948493", "to": "claim_17", "type": "contains_claim"}, {"from": "ff0598d5-47d1-45bf-91bb-ff8e74948493", "to": "claim_18", "type": "contains_claim"}, {"from": "ff0598d5-47d1-45bf-91bb-ff8e74948493", "to": "claim_19", "type": "contains_claim"}, {"from": "ff0598d5-47d1-45bf-91bb-ff8e74948493", "to": "claim_20", "type": "contains_claim"}, {"from": "ff0598d5-47d1-45bf-91bb-ff8e74948493", "to": "claim_21", "type": "contains_claim"}, {"from": "ff0598d5-47d1-45bf-91bb-ff8e74948493", "to": "claim_22", "type": "contains_claim"}, {"from": "ff0598d5-47d1-45bf-91bb-ff8e74948493", "to": "claim_23", "type": "contains_claim"}, {"from": "ff0598d5-47d1-45bf-91bb-ff8e74948493", "to": "claim_24", "type": "contains_claim"}, {"from": "ff0598d5-47d1-45bf-91bb-ff8e74948493", "to": "claim_25", "type": "contains_claim"}, {"from": "ff0598d5-47d1-45bf-91bb-ff8e74948493", "to": "claim_26", "type": "contains_claim"}, {"from": "ff0598d5-47d1-45bf-91bb-ff8e74948493", "to": "claim_27", "type": "contains_claim"}, {"from": "ff0598d5-47d1-45bf-91bb-ff8e74948493", "to": "claim_28", "type": "contains_claim"}, {"from": "ff0598d5-47d1-45bf-91bb-ff8e74948493", "to": "claim_29", "type": "contains_claim"}, {"from": "ff0598d5-47d1-45bf-91bb-ff8e74948493", "to": "claim_30", "type": "contains_claim"}], "nodes": [{"id": "ff0598d5-47d1-45bf-91bb-ff8e74948493", "title": "Research Synthesis: Allostatic Load — full paper", "type": "publication"}, {"id": "claim_1", "text": "What does the current evidence establish about Allostatic Load and human geroscience? This synthesis tests the thesis that evidence for Allostatic load is context-dependent, separating outcome-specific signals from broader claims and identifying the evidence gaps that should bound interpretation. Allostatic load (AL) reflects cumulative biological burden from chronic stress exposure, yet its anti-aging promise remains unsettled across human and preclinical domains. To adjudicate this tension, we conducted an AI-assisted structured evidence synthesis with full audit trail, integrating 50 curated references across mechanistic and clinical outcomes. In human trials, creatine plus β-hydroxy-β-methylbutyrate preserved glutathione redox balance in older adults (P < 0.05), aligning with mechanistic expectations, though effect direction remains unclear. Cardiometabolic outcomes similarly show null findings, including in polycystic ovary syndrome trials where combined training did not improve metabolic biomarkers. Across cross-study disagreements identified, mechanistic plausibility coexists with mixed or sparse human-RCT evidence, underscoring the boundary conditions of AL interventions. Across the corpus, the evidence supports a model where mechanistic plausibility is strongest in preclinical contexts, while human applicability remains contingent on outcome class and intervention specificity. Critical gaps include the lack of harmonized AL indices in clinical trials an", "type": "claim"}, {"id": "claim_2", "text": "The following fields were extracted from each included source: study design, population / cohort, intervention or exposure, comparator, outcome class, effect direction, effect size, confidence interval or credible interval, p-value, sample size, follow-up duration, risk-of-bias rating.", "type": "claim"}, {"id": "claim_3", "text": "Per-source risk-of-bias was rated using design-appropriate Cochrane RoB-2 (RCTs), ROBINS-I (non-randomised studies), and AMSTAR-2 (systematic reviews / meta-analyses). Ratings recorded in `risk_of_bias.json`.", "type": "claim"}, {"id": "claim_4", "text": "Evidence-tension synthesis: claims grouped by outcome class (cardiometabolic, contextual adjacent evidence, deficiency prevalence, dosing and pharmacokinetics, immune, longevity, mortality and survival, safety and comorbidity); within-class agreement, disagreement, and directness gaps surfaced explicitly. Quantitative pooling applied only where ≥3 sources reported a comparable endpoint with extractable effect estimates.", "type": "claim"}, {"id": "claim_5", "text": "Source retrieval, claim extraction, evidence routing, and prose drafting were assisted by large language models under a deterministic audit-trail protocol. Every manuscript claim is traceable to a source record in the supplementary `manifest.json`. Final eligibility and interpretation decisions are author-verified.", "type": "claim"}, {"id": "claim_6", "text": "Outcome-class note:** Contextual Adjacent Evidence denotes background, boundary-condition, or adjacent-outcome sources. It is not pooled with direct outcome evidence.", "type": "claim"}, {"id": "claim_7", "text": "| Contextual Adjacent Evidence | n=23; claims=1056 | null signal in 15/23 sources | 13 indirect; 2 mechanistic; 8 review | limited corpus depth in this outcome class |", "type": "claim"}, {"id": "claim_8", "text": "| Immune | n=9; claims=679 | null signal in 5/9 sources | 2 direct; 3 indirect; 4 review | limited corpus depth in this outcome class |", "type": "claim"}, {"id": "claim_9", "text": "| Cardiometabolic | n=4; claims=274 | null signal in 3/4 sources | 1 direct; 1 indirect; 2 review | limited corpus depth in this outcome class |", "type": "claim"}, {"id": "claim_10", "text": "| Dosing and Pharmacokinetics | n=4; claims=219 | null signal in 4/4 sources | 4 review | limited corpus depth in this outcome class |", "type": "claim"}, {"id": "claim_11", "text": "| Deficiency Prevalence | n=1; claims=113 | null signal in 1/1 sources | 1 indirect | single-source slice; hypothesis-generating |", "type": "claim"}, {"id": "claim_12", "text": "| Mortality and Survival | n=1; claims=29 | null signal in 1/1 sources | 1 indirect | single-source slice; hypothesis-generating |", "type": "claim"}, {"id": "claim_13", "text": "| Safety and Comorbidity | n=1; claims=156 | null signal in 1/1 sources | 1 indirect | single-source slice; hypothesis-generating |", "type": "claim"}, {"id": "claim_14", "text": "The retained allostatic load corpus is reported by outcome class before any cross-domain interpretation. This structure prevents favorable, null, mixed, and adverse evidence from being blended across biologically different endpoints.", "type": "claim"}, {"id": "claim_15", "text": "The contextual adjacent evidence packet includes 23 source-level summaries and 1056 high-confidence observations. Directional coding within this packet is negative=3, null=15, positive=2, unclear=3, and directness coding is indirect=13, mechanistic=2, review=8. These counts describe the frozen evidence state for this outcome, not a pooled treatment estimate.", "type": "claim"}, {"id": "claim_16", "text": "Additional corpus sources included animal/preclinical evidence; representative sources include Fan 2023, Quinn 2022, Nikrad 2023. This outcome is interpreted within its own packet first; any broader synthesis is deferred until the cross-domain section so that the writer cannot merge evidence from unrelated outcome classes.", "type": "claim"}, {"id": "claim_17", "text": "The immune evidence packet includes 9 source-level summaries and 679 high-confidence observations. Directional coding within this packet is mixed=1, null=5, positive=1, unclear=2, and directness coding is direct=2, indirect=3, review=4.", "type": "claim"}, {"id": "claim_18", "text": "Directional coding within this packet is negative=1, null=3, unclear=3, and directness coding is indirect=3, review=4.", "type": "claim"}, {"id": "claim_19", "text": "Directional coding within this packet is null=3, unclear=1, and directness coding is direct=1, indirect=1, review=2.", "type": "claim"}, {"id": "claim_20", "text": "Directional coding within this packet is null=4, and directness coding is review=4.", "type": "claim"}, {"id": "claim_21", "text": "Directional coding within this packet is null=1, and directness coding is indirect=1.", "type": "claim"}, {"id": "claim_22", "text": "Descriptive findings remain separate from interpretation and endpoint-specific boundaries. Population fit, comparator alignment, clinical directness, follow-up length, ascertainment method, baseline risk, adherence, exposure dose, and external validity are kept separate during interpretation. The interpretation", "type": "claim"}, {"id": "claim_23", "text": "Longevity is retained as a separate Results slice (n=7; null signal in 3/7 sources; 3 indirect; no direct clinical anchor) and is not pooled into adjacent endpoint classes.", "type": "claim"}, {"id": "claim_24", "text": "Cardiometabolic is retained as a separate Results slice (n=4; null signal in 3/4 sources; 1 direct; 1 indirect; directionally heterogeneous) and is not pooled into adjacent endpoint classes.", "type": "claim"}, {"id": "claim_25", "text": "Dosing and Pharmacokinetics is retained as a separate Results slice (n=4; null signal in 4/4 sources; not classified; no direct clinical anchor) and is not pooled into adjacent endpoint classes.", "type": "claim"}, {"id": "claim_26", "text": "Deficiency Prevalence is retained as a separate Results slice (n=1; null signal in 1/1 sources; 1 indirect; no direct clinical anchor) and is not pooled into adjacent endpoint classes.", "type": "claim"}, {"id": "claim_27", "text": "Mortality and Survival remains a separate Results slice (n=1; claims=29; null signal in 1/1 sources; 1 indirect; single-source slice; hypothesis-generating) and is not pooled into adjacent endpoint classes.", "type": "claim"}, {"id": "claim_28", "text": "Safety and Comorbidity remains a separate Results slice (n=1; claims=156; null signal in 1/1 sources; 1 indirect; single-source slice; hypothesis-generating) and is not pooled into adjacent endpoint classes.", "type": "claim"}, {"id": "claim_29", "text": "Outcome-class note:** Contextual Adjacent Evidence denotes background, boundary-condition, or adjacent-outcome sources. It is not pooled with direct outcome evidence.", "type": "claim"}, {"id": "claim_30", "text": "| Contextual Adjacent Evidence | n=23; claims=1056 | null signal in 15/23 sources | 13 indirect; 2 mechanistic; 8 review | limited corpus depth in this outcome class |", "type": "claim"}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1007/s10522-026-10407-2", "effect": "not extracted", "endpoint": "not extracted", "id": "source_1", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Ramos-Hernandez 2026", "type": "source", "url": "https://doi.org/10.1007/s10522-026-10407-2", "year": 2026}, {"comparator": "not extracted", "directness": "review-level", "doi": "10.1111/1747-0080.12672", "effect": "not extracted", "endpoint": "not extracted", "id": "source_2", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", 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