Derivation Web

source_d0397261518740e3

by researka:v2 · 2026-06-26 09:16:28.037314+04:00

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Isotemporal substitution of sedentary time with physical activity for cardiovascular health in older adults: a systematic review,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Effects of exercise on metabolic risk, cardiovascular fitness, and body composition in elderly women of the past decade: a systematic review and meta-analysis",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
High-Dose vs Standard-Dose Influenza Vaccine in Older Adults With Diabetes,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effects of detraining on cardiovascular risk factors in older adults: A systematic review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Effect of obicetrapib, a potent cholesteryl ester transfer protein inhibitor, on p-tau217 levels in patients with cardiovascular disease",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
SGLT2 Inhibitors in Older Adults With Cardiovascular Disease: A Systematic Review and Meta‐Analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Mortality Assessment in Patients with Cardiovascular Disease and COVID-19: A Systematic Review and Meta-Analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
A systematic review and meta-analysis of the mechanism of action of Tai Chi on cardiovascular disease: evidence map of aerobic and mind-body exercise pathways,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Cardiovascular risk factors are associated with lower posterior-medial network functional connectivity in older adults,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The Relationship between Sarcopenia and All-Cause and Cardiovascular Mortality Risk among Middle-Aged and Older Adults across Stages 0–3 of Cardiovascular-Kidney-Metabolic Syndrome: Evidence from NHANES and CHARLS,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Associations of triglyceride–glucose-related composite obesity indices with cardiovascular diseases and mortality: a systematic review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Quality of plant-based diets in relation to all-cause and cardiovascular disease mortality in US adults with sarcopenia: a population-based study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Sarcopenic Obesity and Cardiovascular Disease Risk and Mortality: A Systematic Review and Meta-Analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Harnessing Clinical and Biochemical Data for Personalized Cardiovascular Risk Prediction: a Machine Learning Approach Toward Precision Nutrition,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Cardiovascular and glucose-lowering medication use among older adults: results from 9-year follow-up of the FINGER trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Association between ambient temperature and out-of-hospital cardiac arrest: a systematic review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Subendocardial Viability Ratio Is Associated With Target Organ Damage and Hints at a Potential Independent Predictor of Cardiovascular Mortality in Older Adults: A Prospective Cohort Study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Changes in Sarcopenia Status and Subsequent Cardiovascular Outcomes: Prospective Cohort Study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Cardiovascular risk associated with polypharmacy in heart failure: a systematic review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Breaking the silos: a systematic review of oral health integration strategies for improved oral health and cardiovascular outcomes,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
The effect of high-intensity interval training and moderate-intensity continuous training on cardiorespiratory function in healthy elderly individuals: Systematic review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"POLYamine treatment in elderly patients with Coronary Artery Disease (POLYCAD): study protocol for a Danish randomised, double-blind, placebo-controlled trial of spermidine treatment versus placebo",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Dietary manganese, type 2 diabetes, and cardiovascular disease: A UK Biobank cohort study and meta-analysis of over 270,000 individuals",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Frailty and Recurrent Cardiovascular Events in Patients With Obstructive Sleep Apnoea: The SAVE Study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Aspirin, cardiovascular events, and major bleeding in older adults: extended follow-up of the ASPREE trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Efficacy and safety of vutrisiran in transthyretin amyloid cardiomyopathy across the age spectrum: The HELIOS‐B trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Influenza vaccination and cardiovascular and respiratory outcomes in high-risk populations: an umbrella review of systematic reviews and meta-analyzes,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Frailty Matters: Validation of an Automated Electronic Short Physical Performance Battery (eSPPB) for Predicting 30-Day Mortality in Hospitalized Cardiovascular Patients—A Step-by-Step Study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Dietary Inflammatory Index and Cardiovascular Disease Risk in Australian Adults: A Secondary Analysis of the OLIVAUS Trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The Efficacy and Safety of Canagliflozin by Frailty Status in Participants of the CANVAS and CREDENCE Trials,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Risk association and diagnostic value of body roundness index for cardiovascular-kidney-metabolic-related outcomes: a systematic review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Body roundness index and mortality risk in patients with chronic kidney disease: moving beyond the obesity paradox,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Levothyroxine for subclinical hypothyroidism in older adults: no evidence of benefit on quality of life or cardiovascular outcomes: a systematic review,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Rationale and design of ‘discontinuing statins in multimorbid older adults without cardiovascular disease (STREAM)’: study protocol of a randomised non-inferiority clinical trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Beyond BMI: central obesity measures and cardiovascular risk in late life,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Lipoprotein(a)-associated proteomic signature predicts cardiovascular disease in young adults,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Long‐Term Outcomes of Transcatheter Aortic Valve Replacement in Low‐Flow Low‐Gradient Aortic Stenosis: A Reconstructed Time‐to‐Event and Multivariate Meta‐Analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Blood urea nitrogen and cardiovascular disease risk: Evidence from the CHARLS cohort study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Invasive vs Conservative Strategy for Frail Older Patients With Myocardial Infarction,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effects of Exercise on Autonomic Cardiovascular Function in Older Adults: A Systematic Review and Meta-Analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
High-Dose vs Standard-Dose Influenza Vaccines in Older Adults,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"A Randomized, Double-Blind, Placebo-Controlled Trial of an Ayurvedic Herbal Formulation and Vitamin C/E on Vascular Function in Patients with Cardiovascular Disease",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Association of frailty and pre-frailty with cardiovascular mortality: a meta-analysis of 26 cohort studies,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Rationale and Design of CARDIO-TTRansform, a Phase 3 Trial of Eplontersen in Transthyretin Amyloid Cardiomyopathy",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Study protocol for a randomized controlled trial of a culturally adapted cardiovascular dance intervention in Mapuche women with obesity,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Community-based social connection intervention programme to improve cardiovascular and brain health in older adults in rural Ecuador: study protocol for a quasi-experimental trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effects of aerobic exercise on integrated cardiovascular health and energy metabolism in patients with type 2 diabetes mellitus: study protocol for a randomized controlled trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Targeting inflammation in cardiometabolic disease: Icosapent ethyl modulates monocyte‐derived macrophages isolated from patients with cardiovascular disease with or without type 2 diabetes,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
A Multicenter Propensity Score-Matched Cohort Study of Preoperative Antiplatelet Therapy and Postoperative Outcomes in Elderly Surgical Patients,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Joint association of C-reactive protein-triglyceride glucose index-frailty index and non-exercise estimated cardiorespiratory fitness with all-cause mortality in adults aged ≥ 45 years with cardiovascular-kidney-metabolic syndrome stages 0–3: a cross-cohort study using NHANES and CHARLS,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Effects of sodium-glucose cotransporter 2 inhibitors on cardiovascular outcomes in chronic obstructive pulmonary disease: A systematic review, meta-analysis, and trial sequential analysis of randomized controlled trials.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Inflammatory Biomarkers Predicting Major Adverse Cardiovascular Events in People Living With HIV: A Systematic Review and Meta‐Analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Ambient air and noise pollution effect on cardiovascular health risk and lifestyle intervention to attenuate it: study protocol for a randomized clinical trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Frailty Assessment for Risk prediction in Gynecologic Oncology patients undergoing surgery and chemotherapy (FARGO) study protocol: Rationale and design of a multi-centre prospective cohort study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Assessing the Cardiovascular Effects of Levothyroxine Use in an Ageing UK Population with Subclinical Hypothyroidism: Emulated Target Trial (ACEL-UK-ETT).,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Efficacy and safety of folic acid on homocysteine and cardiovascular surrogate biomarkers in hyperhomocysteinemia: a systematic review and meta-analysis of RCTs.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Effects of combining positive psychological intervention and lifestyle intervention on improving cardiovascular health for at-risk older adults: study protocol of a Chinese multicentric community-based randomised controlled trial (ACCOMPLI-CH),not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Association of Acute-Phase IL-6 and SAA with Cardiovascular Events and Mortality Six Years After COVID-19 Infection: An Observational Cohort Study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Colchicine for Major Adverse Cardiovascular Events: An Updated ChatGPT-Assisted Systematic Review and Meta-Analysis.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Strawberries modestly improve cognition and cardiovascular health in older adults.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Resting Heart Rate as a Non-Cardiovascular Mortality Marker in Young Adults: A Population-Based Cohort Study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Tirzepatide vs. semaglutide for obesity, glycemic control, and cardiovascular outcomes: a narrative review of clinical trials",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Rationale, design, and baseline characteristicss of the effect of PCSK9 inhibition on cardiovascular risk in treated HIV infection: EPIC-HIV randomized clinical trial.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Acoramidis, Serum Transthyretin, and Cardiovascular Outcomes in Transthyretin Amyloid Cardiomyopathy: Insights From the ATTRibute-CM Trial.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Ioannidis 2005,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation

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