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by researka:v2 · 2026-06-24 20:43:58.221497+04:00
{"publication_id": "5656b611-9e22-4b55-bce0-289625f554db", "traces": [{"candidate_sources": [{"doi": "10.1016/j.arr.2023.101854", "study": "Does oxidative stress shorten telomeres in vivo? A meta-analysis", "url": "https://doi.org/10.1016/j.arr.2023.101854"}, {"doi": "10.1002/hep4.1803", "study": "Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population", "url": "https://doi.org/10.1002/hep4.1803"}, {"doi": "10.1111/acel.13017", "study": "Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants", "url": "https://doi.org/10.1111/acel.13017"}, {"doi": "10.1158/1055-9965.epi-16-0968", "study": "The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies", "url": "https://doi.org/10.1158/1055-9965.epi-16-0968"}, {"doi": "10.1038/tp.2017.73", "study": "Short telomere length is associated with impaired cognitive performance in European ancestry cohorts", "url": "https://doi.org/10.1038/tp.2017.73"}], "claim": "Across retrieved fact-level receipts for telomere, which endpoints show directionally favorable versus null/non-convergent signals, and what matched PICO remains untested?", "claim_id": "claim_1"}, {"candidate_sources": [{"doi": "10.1016/j.arr.2023.101854", "study": "Does oxidative stress shorten telomeres in vivo? A meta-analysis", "url": "https://doi.org/10.1016/j.arr.2023.101854"}, {"doi": "10.1002/hep4.1803", "study": "Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population", "url": "https://doi.org/10.1002/hep4.1803"}, {"doi": "10.1111/acel.13017", "study": "Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants", "url": "https://doi.org/10.1111/acel.13017"}, {"doi": "10.1158/1055-9965.epi-16-0968", "study": "The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies", "url": "https://doi.org/10.1158/1055-9965.epi-16-0968"}, {"doi": "10.1038/tp.2017.73", "study": "Short telomere length is associated with impaired cognitive performance in European ancestry cohorts", "url": "https://doi.org/10.1038/tp.2017.73"}], "claim": "Finding: The liver disease cohort (HR 1.22, 95% CI 0.99-1.51) had increased mortality risk with shorter TL", "claim_id": "claim_2"}, {"candidate_sources": [{"doi": "10.1016/j.arr.2023.101854", "study": "Does oxidative stress shorten telomeres in vivo? 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A meta-analysis", "url": "https://doi.org/10.1016/j.arr.2023.101854"}, {"doi": "10.1002/hep4.1803", "study": "Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population", "url": "https://doi.org/10.1002/hep4.1803"}, {"doi": "10.1111/acel.13017", "study": "Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants", "url": "https://doi.org/10.1111/acel.13017"}, {"doi": "10.1158/1055-9965.epi-16-0968", "study": "The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies", "url": "https://doi.org/10.1158/1055-9965.epi-16-0968"}, {"doi": "10.1038/tp.2017.73", "study": "Short telomere length is associated with impaired cognitive performance in European ancestry cohorts", "url": "https://doi.org/10.1038/tp.2017.73"}], "claim": "The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies [review; 2017] doi:10.1158/1055-9965.epi-16-0968", "claim_id": "claim_4"}, {"candidate_sources": [{"doi": "10.1016/j.arr.2023.101854", "study": "Does oxidative stress shorten telomeres in vivo? A meta-analysis", "url": "https://doi.org/10.1016/j.arr.2023.101854"}, {"doi": "10.1002/hep4.1803", "study": "Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population", "url": "https://doi.org/10.1002/hep4.1803"}, {"doi": "10.1111/acel.13017", "study": "Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants", "url": "https://doi.org/10.1111/acel.13017"}, {"doi": "10.1158/1055-9965.epi-16-0968", "study": "The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies", "url": "https://doi.org/10.1158/1055-9965.epi-16-0968"}, {"doi": "10.1038/tp.2017.73", "study": "Short telomere length is associated with impaired cognitive performance in European ancestry cohorts", "url": "https://doi.org/10.1038/tp.2017.73"}], "claim": "Finding: In the comparison of the longest versus shortest third of TL, we observed a marginally positive association between longer TL and higher risk of total cancers [OR = 1.086; 95% CI, 0.952-1.238].", "claim_id": "claim_5"}, {"candidate_sources": [{"doi": "10.1016/j.arr.2023.101854", "study": "Does oxidative stress shorten telomeres in vivo? A meta-analysis", "url": "https://doi.org/10.1016/j.arr.2023.101854"}, {"doi": "10.1002/hep4.1803", "study": "Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population", "url": "https://doi.org/10.1002/hep4.1803"}, {"doi": "10.1111/acel.13017", "study": "Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants", "url": "https://doi.org/10.1111/acel.13017"}, {"doi": "10.1158/1055-9965.epi-16-0968", "study": "The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies", "url": "https://doi.org/10.1158/1055-9965.epi-16-0968"}, {"doi": "10.1038/tp.2017.73", "study": "Short telomere length is associated with impaired cognitive performance in European ancestry cohorts", "url": "https://doi.org/10.1038/tp.2017.73"}], "claim": "Finding: longer telomeres were associated with better scores on DSST (β=0.051 per s.d.-increase of TL; 95% CI: 0.024, 0.077; P=0.0002)", "claim_id": "claim_6"}, {"candidate_sources": [{"doi": "10.1016/j.arr.2023.101854", "study": "Does oxidative stress shorten telomeres in vivo? A meta-analysis", "url": "https://doi.org/10.1016/j.arr.2023.101854"}, {"doi": "10.1002/hep4.1803", "study": "Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population", "url": "https://doi.org/10.1002/hep4.1803"}, {"doi": "10.1111/acel.13017", "study": "Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants", "url": "https://doi.org/10.1111/acel.13017"}, {"doi": "10.1158/1055-9965.epi-16-0968", "study": "The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies", "url": "https://doi.org/10.1158/1055-9965.epi-16-0968"}, {"doi": "10.1038/tp.2017.73", "study": "Short telomere length is associated with impaired cognitive performance in European ancestry cohorts", "url": "https://doi.org/10.1038/tp.2017.73"}], "claim": "This receipt-backed scoping note has one bounded signal: telomere shows context-dependent, not uniformly convergent associations across this 5-source primary/review bundle (2017-2023). Grouped by direction, directionally favorable: 1 receipt(s) | other/mixed: 4 receipt(s). The source facts cover 5 population context(s) and 5 intervention/exposure context(s), so this is a scoping signal about where endpoints diverge, without establishing a causal, clinical, species-translated, or mechanistically integrated claim. The listed effect sizes remain source-specific across endpoints and populations; they are not pooled or averaged. Concrete source-level examples: This revealed a significant effect of treatment on telomere dynamics (d=0.36); The liver disease cohort (HR 1.22, 95% CI 0.99-1.51) had increased mortality risk with shorter TL; but raised risk of cancer (OR = 1.11, 95% CI: 1.06-1.16).", "claim_id": "claim_7"}, {"candidate_sources": [{"doi": "10.1016/j.arr.2023.101854", "study": "Does oxidative stress shorten telomeres in vivo? A meta-analysis", "url": "https://doi.org/10.1016/j.arr.2023.101854"}, {"doi": "10.1002/hep4.1803", "study": "Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population", "url": "https://doi.org/10.1002/hep4.1803"}, {"doi": "10.1111/acel.13017", "study": "Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants", "url": "https://doi.org/10.1111/acel.13017"}, {"doi": "10.1158/1055-9965.epi-16-0968", "study": "The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies", "url": "https://doi.org/10.1158/1055-9965.epi-16-0968"}, {"doi": "10.1038/tp.2017.73", "study": "Short telomere length is associated with impaired cognitive performance in European ancestry cohorts", "url": "https://doi.org/10.1038/tp.2017.73"}], "claim": "null/non-convergent or other/mixed: the extracted fact is null, mixed, or not directionally interpretable.", "claim_id": "claim_8"}, {"candidate_sources": [{"doi": "10.1016/j.arr.2023.101854", "study": "Does oxidative stress shorten telomeres in vivo? A meta-analysis", "url": "https://doi.org/10.1016/j.arr.2023.101854"}, {"doi": "10.1002/hep4.1803", "study": "Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population", "url": "https://doi.org/10.1002/hep4.1803"}, {"doi": "10.1111/acel.13017", "study": "Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants", "url": "https://doi.org/10.1111/acel.13017"}, {"doi": "10.1158/1055-9965.epi-16-0968", "study": "The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies", "url": "https://doi.org/10.1158/1055-9965.epi-16-0968"}, {"doi": "10.1038/tp.2017.73", "study": "Short telomere length is associated with impaired cognitive performance in European ancestry cohorts", "url": "https://doi.org/10.1038/tp.2017.73"}], "claim": "other/mixed: Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population — The liver disease cohort (HR 1.22, 95% CI 0.99-1.51) had increased mortality risk with shorter TL", "claim_id": "claim_9"}, {"candidate_sources": [{"doi": "10.1016/j.arr.2023.101854", "study": "Does oxidative stress shorten telomeres in vivo? A meta-analysis", "url": "https://doi.org/10.1016/j.arr.2023.101854"}, {"doi": "10.1002/hep4.1803", "study": "Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population", "url": "https://doi.org/10.1002/hep4.1803"}, {"doi": "10.1111/acel.13017", "study": "Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants", "url": "https://doi.org/10.1111/acel.13017"}, {"doi": "10.1158/1055-9965.epi-16-0968", "study": "The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies", "url": "https://doi.org/10.1158/1055-9965.epi-16-0968"}, {"doi": "10.1038/tp.2017.73", "study": "Short telomere length is associated with impaired cognitive performance in European ancestry cohorts", "url": "https://doi.org/10.1038/tp.2017.73"}], "claim": "other/mixed: Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants — but raised risk of cancer (OR = 1.11, 95% CI: 1.06-1.16)", "claim_id": "claim_10"}, {"candidate_sources": [{"doi": "10.1016/j.arr.2023.101854", "study": "Does oxidative stress shorten telomeres in vivo? A meta-analysis", "url": "https://doi.org/10.1016/j.arr.2023.101854"}, {"doi": "10.1002/hep4.1803", "study": "Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population", "url": "https://doi.org/10.1002/hep4.1803"}, {"doi": "10.1111/acel.13017", "study": "Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants", "url": "https://doi.org/10.1111/acel.13017"}, {"doi": "10.1158/1055-9965.epi-16-0968", "study": "The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies", "url": "https://doi.org/10.1158/1055-9965.epi-16-0968"}, {"doi": "10.1038/tp.2017.73", "study": "Short telomere length is associated with impaired cognitive performance in European ancestry cohorts", "url": "https://doi.org/10.1038/tp.2017.73"}], "claim": "other/mixed: The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies — In the comparison of the longest versus shortest third of TL, we observed a marginally positive association between longer TL and higher risk of total cancers [OR = 1.086; 95% CI, 0.952-1.238].", "claim_id": "claim_11"}, {"candidate_sources": [{"doi": "10.1016/j.arr.2023.101854", "study": "Does oxidative stress shorten telomeres in vivo? A meta-analysis", "url": "https://doi.org/10.1016/j.arr.2023.101854"}, {"doi": "10.1002/hep4.1803", "study": "Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population", "url": "https://doi.org/10.1002/hep4.1803"}, {"doi": "10.1111/acel.13017", "study": "Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants", "url": "https://doi.org/10.1111/acel.13017"}, {"doi": "10.1158/1055-9965.epi-16-0968", "study": "The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies", "url": "https://doi.org/10.1158/1055-9965.epi-16-0968"}, {"doi": "10.1038/tp.2017.73", "study": "Short telomere length is associated with impaired cognitive performance in European ancestry cohorts", "url": "https://doi.org/10.1038/tp.2017.73"}], "claim": "directionally favorable: Short telomere length is associated with impaired cognitive performance in European ancestry cohorts — longer telomeres were associated with better scores on DSST (β=0.051 per s.d.-increase of TL; 95% CI: 0.024, 0.077; P=0.0002)", "claim_id": "claim_12"}, {"candidate_sources": [{"doi": "10.1016/j.arr.2023.101854", "study": "Does oxidative stress shorten telomeres in vivo? A meta-analysis", "url": "https://doi.org/10.1016/j.arr.2023.101854"}, {"doi": "10.1002/hep4.1803", "study": "Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population", "url": "https://doi.org/10.1002/hep4.1803"}, {"doi": "10.1111/acel.13017", "study": "Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants", "url": "https://doi.org/10.1111/acel.13017"}, {"doi": "10.1158/1055-9965.epi-16-0968", "study": "The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies", "url": "https://doi.org/10.1158/1055-9965.epi-16-0968"}, {"doi": "10.1038/tp.2017.73", "study": "Short telomere length is associated with impaired cognitive performance in European ancestry cohorts", "url": "https://doi.org/10.1038/tp.2017.73"}], "claim": "Specific moderators in this bundle are population/indication (13,894 cases and 71,672 controls from 28 studies in 25 articles; European ancestry cohorts (N=17,052; mean age=59.2±8.8 years); UK Biobank participants aged 60 and older; interventional studies manipulating oxidative stress; liver disease cohort), study design/evidence type (primary/review). Single primary-study estimates are separated from pooled review or meta-analytic estimates rather than treated as interchangeable.", "claim_id": "claim_13"}, {"candidate_sources": [{"doi": "10.1016/j.arr.2023.101854", "study": "Does oxidative stress shorten telomeres in vivo? 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