source · application/json
source_d094c031536f4930
sha256 9ab1ae27c0a4f6f4818e2fc19c9a734ea3df7c8ca27089bd3f378c89c1484b52
by researka:v2 · 2026-05-27 23:44:05.562379+04:00
{"publication_id": "002f5fe8-38f1-4b5a-b1a1-3cdff72ddedd", "traces": [{"candidate_sources": [{"doi": "10.1111/acel.13017", "study": "Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants", "url": null}, {"doi": "10.1158/1055-9965.epi-16-0968", "study": "The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies", "url": null}, {"doi": "10.1164/rccm.201902-0360oc", "study": "Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis", "url": null}, {"doi": "10.1016/j.arr.2018.09.002", "study": "Telomere Length and All-Cause Mortality: A Meta-analysis", "url": null}, {"doi": "10.1016/j.arr.2022.101679", "study": "Telomere length and brain aging: A systematic review and meta-analysis", "url": null}], "claim": "Headline:** Cardiovascular protection versus cancer risk: a Mendelian randomization and meta-analysis synthesis of telomere length effects", "claim_id": "claim_1"}, {"candidate_sources": [{"doi": "10.1111/acel.13017", "study": "Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants", "url": null}, {"doi": "10.1158/1055-9965.epi-16-0968", "study": "The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies", "url": null}, {"doi": "10.1164/rccm.201902-0360oc", "study": "Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis", "url": null}, {"doi": "10.1016/j.arr.2018.09.002", "study": "Telomere Length and All-Cause Mortality: A Meta-analysis", "url": null}, {"doi": "10.1016/j.arr.2022.101679", "study": "Telomere length and brain aging: A systematic review and meta-analysis", "url": null}], "claim": "The cited A/B receipts support a specific working claim: Genetically determined longer telomere length was associated with lowered risk of coronary heart disease (CHD; OR = 0.95, 95% CI: 0.92-0.98); but raised risk of cancer (OR = 1.11, 95% CI: 1.06-1.16). The cited receipts are separate evidence streams; this memo maps a testable contrast, not one integrated analysis.", "claim_id": "claim_2"}, {"candidate_sources": [{"doi": "10.1111/acel.13017", "study": "Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants", "url": null}, {"doi": "10.1158/1055-9965.epi-16-0968", "study": "The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies", "url": null}, {"doi": "10.1164/rccm.201902-0360oc", "study": "Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis", "url": null}, {"doi": "10.1016/j.arr.2018.09.002", "study": "Telomere Length and All-Cause Mortality: A Meta-analysis", "url": null}, {"doi": "10.1016/j.arr.2022.101679", "study": "Telomere length and brain aging: A systematic review and meta-analysis", "url": null}], "claim": "Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication.", "claim_id": "claim_3"}, {"candidate_sources": [{"doi": "10.1111/acel.13017", "study": "Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants", "url": null}, {"doi": "10.1158/1055-9965.epi-16-0968", "study": "The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies", "url": null}, {"doi": "10.1164/rccm.201902-0360oc", "study": "Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis", "url": null}, {"doi": "10.1016/j.arr.2018.09.002", "study": "Telomere Length and All-Cause Mortality: A Meta-analysis", "url": null}, {"doi": "10.1016/j.arr.2022.101679", "study": "Telomere length and brain aging: A systematic review and meta-analysis", "url": null}], "claim": "The evidence exposes a paradoxical role of telomere length—cardioprotective yet carcinogenic—modulated by methodological heterogeneity and genetic background, suggesting that risk assessment must account for measurement techniques and disease-specific contexts.", "claim_id": "claim_4"}, {"candidate_sources": [{"doi": "10.1111/acel.13017", "study": "Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants", "url": null}, {"doi": "10.1158/1055-9965.epi-16-0968", "study": "The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies", "url": null}, {"doi": "10.1164/rccm.201902-0360oc", "study": "Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis", "url": null}, {"doi": "10.1016/j.arr.2018.09.002", "study": "Telomere Length and All-Cause Mortality: A Meta-analysis", "url": null}, {"doi": "10.1016/j.arr.2022.101679", "study": "Telomere length and brain aging: A systematic review and meta-analysis", "url": null}], "claim": "Known / obvious (do not republish): Telomere length shortens with chronological age; Shorter telomeres are associated with increased all-cause mortality risk", "claim_id": "claim_5"}, {"candidate_sources": [{"doi": "10.1111/acel.13017", "study": "Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants", "url": null}, {"doi": "10.1158/1055-9965.epi-16-0968", "study": "The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies", "url": null}, {"doi": "10.1164/rccm.201902-0360oc", "study": "Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis", "url": null}, {"doi": "10.1016/j.arr.2018.09.002", "study": "Telomere Length and All-Cause Mortality: A Meta-analysis", "url": null}, {"doi": "10.1016/j.arr.2022.101679", "study": "Telomere length and brain aging: A systematic review and meta-analysis", "url": null}], "claim": "Real tension: Fact 109012 (lower CHD risk with longer TL) vs Fact 109013 (higher cancer risk with longer TL) in the same UK Biobank population aged 60+", "claim_id": "claim_6"}, {"candidate_sources": [{"doi": "10.1111/acel.13017", "study": "Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants", "url": null}, {"doi": "10.1158/1055-9965.epi-16-0968", "study": "The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies", "url": null}, {"doi": "10.1164/rccm.201902-0360oc", "study": "Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis", "url": null}, {"doi": "10.1016/j.arr.2018.09.002", "study": "Telomere Length and All-Cause Mortality: A Meta-analysis", "url": null}, {"doi": "10.1016/j.arr.2022.101679", "study": "Telomere length and brain aging: A systematic review and meta-analysis", "url": null}], "claim": "`fact_id=109012` (`A_core`) — Genetically determined longer telomere length was associated with lowered risk of coronary heart disease (CHD; OR = 0.95, 95% CI: 0.92-0.98) doi=10.1111/acel.13017", "claim_id": "claim_7"}, {"candidate_sources": [{"doi": "10.1111/acel.13017", "study": "Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants", "url": null}, {"doi": "10.1158/1055-9965.epi-16-0968", "study": "The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies", "url": null}, {"doi": "10.1164/rccm.201902-0360oc", "study": "Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis", "url": null}, {"doi": "10.1016/j.arr.2018.09.002", "study": "Telomere Length and All-Cause Mortality: A Meta-analysis", "url": null}, {"doi": "10.1016/j.arr.2022.101679", "study": "Telomere length and brain aging: A systematic review and meta-analysis", "url": null}], "claim": "`fact_id=109013` (`A_core`) — but raised risk of cancer (OR = 1.11, 95% CI: 1.06-1.16) doi=10.1111/acel.13017", "claim_id": "claim_8"}, {"candidate_sources": [{"doi": "10.1111/acel.13017", "study": "Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants", "url": null}, {"doi": "10.1158/1055-9965.epi-16-0968", "study": "The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies", "url": null}, {"doi": "10.1164/rccm.201902-0360oc", "study": "Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis", "url": null}, {"doi": "10.1016/j.arr.2018.09.002", "study": "Telomere Length and All-Cause Mortality: A Meta-analysis", "url": null}, {"doi": "10.1016/j.arr.2022.101679", "study": "Telomere length and brain aging: A systematic review and meta-analysis", "url": null}], "claim": "`fact_id=3475` (`A_core`) — In the comparison of the longest versus shortest third of TL, we observed a marginally positive association between longer TL and higher risk of total cancers [OR = 1.086; 95% CI, 0.952-1.238]. doi=10.1158/1055-9965.epi-16-0968", "claim_id": "claim_9"}, {"candidate_sources": [{"doi": "10.1111/acel.13017", "study": "Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants", "url": null}, {"doi": "10.1158/1055-9965.epi-16-0968", "study": "The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies", "url": null}, {"doi": "10.1164/rccm.201902-0360oc", "study": "Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis", "url": null}, {"doi": "10.1016/j.arr.2018.09.002", "study": "Telomere Length and All-Cause Mortality: A Meta-analysis", "url": null}, {"doi": "10.1016/j.arr.2022.101679", "study": "Telomere length and brain aging: A systematic review and meta-analysis", "url": null}], "claim": "_No A_core/B_context counter-evidence found in this run; treat this as a single-direction signal until a broader receipt expansion finds a real opposing fact._", "claim_id": "claim_10"}, {"candidate_sources": [{"doi": "10.1111/acel.13017", "study": "Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants", "url": null}, {"doi": "10.1158/1055-9965.epi-16-0968", "study": "The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies", "url": null}, {"doi": "10.1164/rccm.201902-0360oc", "study": "Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis", "url": null}, {"doi": "10.1016/j.arr.2018.09.002", "study": "Telomere Length and All-Cause Mortality: A Meta-analysis", "url": null}, {"doi": "10.1016/j.arr.2022.101679", "study": "Telomere length and brain aging: A systematic review and meta-analysis", "url": null}], "claim": "Suggested citation:** Dom Lynch. (2026). Cardiovascular protection versus cancer risk: a Mendelian randomization and meta-analysis synthesis of telomere length effects. ReseaRka Evidence Index. Version 1.0.", "claim_id": "claim_11"}, {"candidate_sources": [{"doi": "10.1111/acel.13017", "study": "Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants", "url": null}, {"doi": "10.1158/1055-9965.epi-16-0968", "study": "The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies", "url": null}, {"doi": "10.1164/rccm.201902-0360oc", "study": "Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis", "url": null}, {"doi": "10.1016/j.arr.2018.09.002", "study": "Telomere Length and All-Cause Mortality: A Meta-analysis", "url": null}, {"doi": "10.1016/j.arr.2022.101679", "study": "Telomere length and brain aging: A systematic review and meta-analysis", "url": null}], "claim": "Priority note:** This memo records the first published framing, source bundle, and evidence receipts for this run. Reuse should cite the canonical version.", "claim_id": "claim_12"}]}
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