Derivation Web

source_d0ec4f4243c84546

by researka:v2 · 2026-06-20 10:19:32.939130+04:00

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Different RONS Generation in MTC-SK and NSCL Cells Lead to Varying Antitumoral Effects of Alpha-Ketoglutarate + 5-HMF,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Alpha-Ketoglutarate or 5-HMF: Single Compounds Effectively Eliminate Leukemia Cells via Caspase-3 Apoptosis and Antioxidative Pathways,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Alpha-ketoglutarate rescues impaired endothelial progenitor cell-mediated angiogenesis in diabetic mice,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Alpha-Ketoglutarate and 5-HMF: A Potential Anti-Tumoral Combination against Leukemia Cells,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Low Protein Diets Supplemented With Alpha-Ketoglutarate Enhance the Growth Performance, Immune Response, and Intestinal Health in Common Carp ( Cyprinus carpio )",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Alpha-ketoglutarate ameliorates pressure overload-induced chronic cardiac dysfunction in mice,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Alpha-Ketoglutarate: An Effective Feed Supplement in Improving Bone Metabolism and Muscle Quality of Laying Hens: A Preliminary Study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Evaluation of Alpha-Ketoglutarate Supplementation on the Improvement of Intestinal Antioxidant Capacity and Immune Response in Songpu Mirror Carp ( Cyprinus carpio ) After Infection With Aeromonas hydrophila,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Dietary Alpha-Ketoglutarate Partially Abolishes Adverse Changes in the Small Intestine after Gastric Bypass Surgery in a Rat Model,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Alpha-ketoglutarate supplementation improves hyperglycemia and attenuates the decrease in GLUT4 and PGC-1α proteins in adipose tissue of streptozotocin-high-fat diet-induced diabetic mice,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Alpha-ketoglutarate mitigates insulin resistance and metabolic inflexibility in a mouse model of Ataxia-Telangiectasia,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Alpha Ketoglutarate Exerts In Vitro Anti-Osteosarcoma Effects through Inhibition of Cell Proliferation, Induction of Apoptosis via the JNK and Caspase 9-Dependent Mechanism, and Suppression of TGF-β and VEGF Production and Metastatic Potential of Cells",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Epigenetic modifier alpha-ketoglutarate modulates aberrant gene body methylation and hydroxymethylation marks in diabetic heart,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Dietary Alpha-Ketoglutarate Supplementation Improves Bone Growth, Phosphorus Digestion, and Growth Performance in Piglets",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effects of N-Acetylcysteine and Alpha-Ketoglutarate on OVCAR3 Ovarian Cancer Cells: Insights from Integrative Bioinformatics and Experimental Validation,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Alpha-ketoglutarate promotes random-pattern skin flap survival by enhancing angiogenesis via PI3K/Akt/HIF-1α signaling pathway,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Alpha-ketoglutarate ameliorates abdominal aortic aneurysm via inhibiting PXDN/HOCL/ERK signaling pathways,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Alpha-ketoglutarate supplementation and BiologicaL agE in middle-aged adults (ABLE)—intervention study protocol,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Elevation of Intracellular Alpha-Ketoglutarate Levels Inhibits Osteoclastogenesis by Suppressing the NF-κB Signaling Pathway in a PHD1-Dependent Manner,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Alpha-ketoglutarate enhances adipose-derived stem cells survival in wound healing by hypoxia-inducible factor 1-alpha-mediated redox homeostasis and glycogen-dependent bioenergetics,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Development and First-in-Human Translation of Hyperpolarized [1- 13 C]Alpha-Ketoglutarate MR Spectroscopy in the Brain,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Effects of Alpha-Ketoglutarate Supplementation on Growth Performance, Diarrhea Incidence, Plasma Amino Acid, and Nutrient Digestibility in Weaned Piglets",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Alpha-Ketoglutarate Regulates Tnfrsf12a/Fn14 Expression via Histone Modification and Prevents Cancer-Induced Cachexia,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Cholesterol Content, Fatty Acid Profile and Health Lipid Indices in the Egg Yolk of Eggs from Hens at the End of the Laying Cycle, Following Alpha-Ketoglutarate Supplementation",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effects of Dietary Alpha-Ketoglutarate Supplementation on Diarrhea Incidence and Nutrient Digestibility in Weaned Piglets Fed Low-Protein Diets,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Alpha-Ketoglutarate Promotes Goblet Cell Differentiation and Alters Urea Cycle Metabolites in DSS-Induced Colitis Mice,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Alpha-Ketoglutarate: A Potential Inner Mitochondrial and Cytosolic Protector against Peroxynitrite and Peroxynitrite-Induced Nitration?,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Lack of association of the alpha-ketoglutarate-dependent dioxygenase (FTO) gene polymorphisms with pulmonary tuberculosis risk: a systematic review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"AKT signaling is associated with epigenetic reprogramming via the upregulation of TET and its cofactor, alpha-ketoglutarate during iPSC generation",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The Role of the Rare Variants in the Genes Encoding the Alpha-Ketoglutarate Dehydrogenase in Alzheimer’s Disease,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Foliar application of alpha-ketoglutarate plus nitrogen improves drought resistance in soybean ( Glycine max L. Merr. ),not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Repurposing FDA-approved drugs to find a novel inhibitor of alpha-ketoglutarate-dependent dioxygenase FTO to treat esophageal cancer,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Alpha Ketoglutarate Downregulates the Neutral Endopeptidase and Enhances the Growth Inhibitory Activity of Thiorphan in Highly Aggressive Osteosarcoma Cells,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Alpha-Ketoglutarate Drives an Osteogenic and Extracellular Matrix Gene Program in Periodontal Ligament Fibroblasts via Selective Reduction of H3K27me3,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Alpha-ketoglutarate utilization in Saccharomyces cerevisiae : transport, compartmentation and catabolism",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
A scoping review regarding reproductive capacity modulation based on alpha-ketoglutarate supplementation,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Alpha-Ketoglutarate in Low-Protein Diets for Growing Pigs: Effects on Cecal Microbial Communities and Parameters of Microbial Metabolism,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effects of Dietary Supplementation of Alpha-Ketoglutarate in a Low-Protein Diet on Fatty Acid Composition and Lipid Metabolism Related Gene Expression in Muscles of Growing Pigs,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effects of Long-Term Cultivation on Medium with Alpha-Ketoglutarate Supplementation on Metabolic Processes of Saccharomyces cerevisiae,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Glutaminase 1 regulates the release of extracellular vesicles during neuroinflammation through key metabolic intermediate alpha-ketoglutarate,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Replication Study: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Alpha-ketoglutarate suppresses the NF-κB-mediated inflammatory pathway and enhances the PXR-regulated detoxification pathway,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Administration of alpha-ketoglutarate improves epithelial restitution under stress injury in early-weaning piglets,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Growth on Alpha-Ketoglutarate Increases Oxidative Stress Resistance in the Yeast Saccharomyces cerevisiae,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Alpha-ketoglutarate promotes skeletal muscle hypertrophy and protein synthesis through Akt/mTOR signaling pathways,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Mutations in human lipoyltransferase gene LIPT1 cause a Leigh disease with secondary deficiency for pyruvate and alpha-ketoglutarate dehydrogenase,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Comparative Study of Various Delivery Methods for the Supply of Alpha-Ketoglutarate to the Neural Cells for Tissue Engineering,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Alpha-Ketoglutarate: Physiological Functions and Applications,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Registered report: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Studenski 2011,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Perera 2006,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
ADA 2024,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
WHO 2000,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Cruz-Jentoft 2019,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Ioannidis 2005,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation

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