Derivation Web

source_d4be4411d9f6410e

by researka:v2 · 2026-07-01 15:53:32.661297+04:00

# Alpha memo: nicotinamide exercise performance context boundary

**One-sentence alpha:** The hot water extract and active components nicotinamide and guanosine of the leather carp Cyprinus carpio nudis improve exercise performance in mice. made us expect nicotinamide would travel cleanly as a positive signal; Additional file 1: of The NAD+ precursor nicotinamide riboside decreases exercise performance in rats forces the update that the same anchor can fail, reverse, or split by context.

**Receipt 1:** Additional file 1: of The NAD+ precursor nicotinamide riboside decreases exercise performance in rats | 2016 | 10.6084/m9.figshare.c.3601490_d1 | finding: Raw data of time to exhaustion in the incremental swimming test for the control and the nicotinamide riboside group. (XLSX 9Â kb)

**Receipt 2:** The hot water extract and active components nicotinamide and guanosine of the leather carp Cyprinus carpio nudis improve exercise performance in mice. | 2019 | 10.1111/jfbc.13004 | finding: We identified the main active, exercise performance-enhancing compounds in a hot water extract of the leather carp, Cyprinus carpio nudus, as nicotinamide and guanosine. Mice were fed casein (30 mg/ml) enriched with nicotinamide (0.1 mg/ml) and guanosine (0.05

**Why this is surprising:** The pair has `promise_reversal` geometry over `nicotinamide, exercise, performance` rather than a broad literature-summary bridge.

**Caveats/falsifiers:**
- Reject if the shared anchor is not the same construct/intervention in the full text.
- Reject if later receipts show the apparent reversal is only population, dose, or measurement noise.
- Reject if either receipt is a review, case-only report, or keyword-only match.

**Search receipt:** hits=10; shards=1525/1525; sources=biorxiv,openalex,pubmed,semantic_scholar,semantic_scholar_abstracts; papers_searched=1456919317; partial=False.

{
  "article_type": "alpha_memo",
  "domain_slug": "longevity_research",
  "researka_object_type": "submission",
  "researka_submission_id": "eb01974b-015d-466b-8031-68d430365e63",
  "title": "Alpha memo: nicotinamide exercise performance context boundary"
}