Derivation Web

source_d5f7ab0f2ba64519

by researka:v2 · 2026-06-24 17:51:59.830470+04:00

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
The effects of berberine on inflammatory markers in Chinese patients with metabolic syndrome and related disorders: a meta‑analysis of randomized controlled trials,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Comparative efficacy of oral insulin sensitizers metformin, thiazolidinediones, inositol, and berberine in improving endocrine and metabolic profiles in women with PCOS: a network meta-analysis",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Efficacy and safety of HIMABERB® Berberine on glycemic control in patients with prediabetes: double-blind, placebo-controlled, and randomized pilot trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Efficacy and safety of berberine on the components of metabolic syndrome: a systematic review and meta-analysis of randomized placebo-controlled trials,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
The Effect of Berberine on Metabolic Profiles in Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Combined berberine and probiotic treatment as an effective regimen for improving postprandial hyperlipidemia in type 2 diabetes patients: a double blinded placebo controlled randomized study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Berberine Ursodeoxycholate for the Treatment of Type 2 Diabetes,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: a meta-analysis and systematic review,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"In Vitro Analyses of the Multifocal Effects of Natural Alkaloids Berberine, Matrine, and Tabersonine against the O’nyong-nyong Arthritogenic Alphavirus Infection and Inflammation",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effect of berberine on cognitive function and β-amyloid precursor protein in Alzheimer’s disease models: a systematic review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Berberine and Adiposity in Diabetes-Free Individuals With Obesity and MASLD,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Probiotics, synbiotics and berberine in Type 2 diabetes mellitus: A systematic review, meta-analysis, and molecular dynamics simulation study",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"A phase 2, proof of concept, randomised controlled trial of berberine ursodeoxycholate in patients with presumed non-alcoholic steatohepatitis and type 2 diabetes",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"The Possible Synergistic Pharmacological Effect of an Oral Berberine (BBR) and Curcumin (CUR) Complementary Therapy Alleviates Symptoms of Irritable Bowel Syndrome (IBS): Results from a Real-Life, Routine Clinical Practice Settings-Based Study",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Berberine Effects in Pre-Fibrotic Stages of Non-Alcoholic Fatty Liver Disease—Clinical and Pre-Clinical Overview and Systematic Review of the Literature,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Comparative Effects of Gymnema sylvestre and Berberine on Adipokines, Body Composition, and Metabolic Parameters in Obese Patients: A Randomized Study",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Berberine Phospholipid Is an Effective Insulin Sensitizer and Improves Metabolic and Hormonal Disorders in Women with Polycystic Ovary Syndrome: A One-Group Pretest–Post-Test Explanatory Study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Berberine-loaded PLGA nanoparticles alleviate ulcerative colitis by targeting IL-6/IL-6R axis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Biofilm-mediated resistance to berberine in Escherichia coli,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Inflammatory markers and noncoding‐ RNAs responses to low and high compressions of HIIT with or without berberine supplementation in middle‐aged men with prediabetes,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"The Influence of Berberine on Vascular Function Parameters, Among Them VEGF, in Individuals with MAFLD: A Double-Blind, Randomized, Placebo-Controlled Trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Berberine chloride suppresses pancreatic adenocarcinoma proliferation and growth by targeting inflammation-related genes: an in silico analysis with in vitro and vivo validation,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Berberine and health outcomes: an overview of systematic reviews,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The antibacterial activity of berberine against Cutibacterium acnes : its therapeutic potential in inflammatory acne,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Adjunctive berberine improves hormonal, metabolic, and inflammatory profiles in women with polycystic ovary syndrome: a retrospective case–control study",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Berberine Ameliorates High-fat-induced Insulin Resistance in HepG2 Cells by Modulating PPARs Signaling Pathway,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Impact of Berberine or Berberine Combination Products on Lipoprotein, Triglyceride and Biological Safety Marker Concentrations in Patients with Hyperlipidemia: A Systematic Review and Meta-Analysis.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Overall and Sex-Specific Effect of Berberine on Glycemic and Insulin-Related Traits: a Systematic Review and Meta-Analysis of Randomized Controlled Trials.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Overall and Sex-Specific Effect of Berberine for the Treatment of Dyslipidemia in Adults: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Adjunctive berberine reduces antipsychotic-associated weight gain and metabolic syndrome in patients with schizophrenia: a randomized controlled trial.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Berberine protects hepatocyte from hypoxia/reoxygenation-induced injury through inhibiting circDNTTIP2,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Enhancing insulin secretion by pancreatic β-cell redifferentiation: a study of the anti-diabetic effects of berberine in vitro,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Clinical Efficacy of Curcumin, Resveratrol, Silymarin, and Berberine on Cardio-Metabolic Risk Factors Among Patients With Type 2 Diabetes Mellitus: A Systemic Review and Bayesian Network Meta-Analysis.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Effect of berberine on insulin resistance in women with polycystic ovary syndrome: study protocol for a randomized multicenter controlled trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
ADA 2024,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Cruz-Jentoft 2019,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Tancredi 2015,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Ioannidis 2005,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation

{
  "researka_object_type": "publication_sidecar",
  "researka_publication_id": "a1f46e6e-cd1b-40a7-8641-5b96e4526923",
  "researka_submission_id": "6f0113a2-1cfe-44a3-9477-90e14d164f8b",
  "sidecar_name": "evidence_table.csv",
  "sidecar_url": "https://api.researka.org/publications/a1f46e6e-cd1b-40a7-8641-5b96e4526923/sidecars/evidence_table.csv"
}