Derivation Web

source_d6f3d4f92bc248c9

by researka:v2 · 2026-05-28 12:02:27.784531+04:00

{"publication_id": "89707573-02b4-4757-8c0d-0454119a5cb3", "traces": [{"candidate_sources": [{"doi": "10.1002/ijc.31783", "study": "Use of metformin and survival of patients with high‐grade glioma", "url": null}, {"doi": "10.1093/brain/awad366", "study": "Metformin in elderly type 2 diabetes mellitus: dose-dependent dementia risk reduction", "url": null}, {"doi": "10.3389/fmed.2021.640785", "study": "Association Between Preadmission Metformin Use and Outcomes in Intensive Care Unit Patients With Sepsis and Type 2 Diabetes: A Cohort Study", "url": null}, {"doi": "10.1016/j.aohep.2019.10.005", "study": "Metformin in the prevention of hepatocellular carcinoma in diabetic patients: A systematic review", "url": null}, {"doi": "10.3389/fmed.2021.704666", "study": "Metformin in Patients With COVID-19: A Systematic Review and Meta-Analysis", "url": null}], "claim": "The cited A/B receipts support a specific working claim: Use of metformin was associated with a significantly better overall and progression-free survival of patients with WHO grade III glioma (HR for OS = 0.30; 95% CI = 0.11-0.81); HR for PFS = 0.29; 95% CI = 0.11-0.78. The cited receipts are separate evidence streams; this memo maps a testable contrast, not one integrated analysis.", "claim_id": "claim_1"}, {"candidate_sources": [{"doi": "10.1002/ijc.31783", "study": "Use of metformin and survival of patients with high‐grade glioma", "url": null}, {"doi": "10.1093/brain/awad366", "study": "Metformin in elderly type 2 diabetes mellitus: dose-dependent dementia risk reduction", "url": null}, {"doi": "10.3389/fmed.2021.640785", "study": "Association Between Preadmission Metformin Use and Outcomes in Intensive Care Unit Patients With Sepsis and Type 2 Diabetes: A Cohort Study", "url": null}, {"doi": "10.1016/j.aohep.2019.10.005", "study": "Metformin in the prevention of hepatocellular carcinoma in diabetic patients: A systematic review", "url": null}, {"doi": "10.3389/fmed.2021.704666", "study": "Metformin in Patients With COVID-19: A Systematic Review and Meta-Analysis", "url": null}], "claim": "Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication.", "claim_id": "claim_2"}, {"candidate_sources": [{"doi": "10.1002/ijc.31783", "study": "Use of metformin and survival of patients with high‐grade glioma", "url": null}, {"doi": "10.1093/brain/awad366", "study": "Metformin in elderly type 2 diabetes mellitus: dose-dependent dementia risk reduction", "url": null}, {"doi": "10.3389/fmed.2021.640785", "study": "Association Between Preadmission Metformin Use and Outcomes in Intensive Care Unit Patients With Sepsis and Type 2 Diabetes: A Cohort Study", "url": null}, {"doi": "10.1016/j.aohep.2019.10.005", "study": "Metformin in the prevention of hepatocellular carcinoma in diabetic patients: A systematic review", "url": null}, {"doi": "10.3389/fmed.2021.704666", "study": "Metformin in Patients With COVID-19: A Systematic Review and Meta-Analysis", "url": null}], "claim": "Metformin's clinical effects are stratified by disease pathology and acuity, as shown by its selective survival benefit in WHO grade III but not grade IV glioma and its consistent mortality reduction in acute sepsis and COVID-19, suggesting context-dependent mechanisms that challenge uniform therapeutic application.", "claim_id": "claim_3"}, {"candidate_sources": [{"doi": "10.1002/ijc.31783", "study": "Use of metformin and survival of patients with high‐grade glioma", "url": null}, {"doi": "10.1093/brain/awad366", "study": "Metformin in elderly type 2 diabetes mellitus: dose-dependent dementia risk reduction", "url": null}, {"doi": "10.3389/fmed.2021.640785", "study": "Association Between Preadmission Metformin Use and Outcomes in Intensive Care Unit Patients With Sepsis and Type 2 Diabetes: A Cohort Study", "url": null}, {"doi": "10.1016/j.aohep.2019.10.005", "study": "Metformin in the prevention of hepatocellular carcinoma in diabetic patients: A systematic review", "url": null}, {"doi": "10.3389/fmed.2021.704666", "study": "Metformin in Patients With COVID-19: A Systematic Review and Meta-Analysis", "url": null}], "claim": "_No A_core/B_context counter-evidence found in this run; treat this as a single-direction signal until a broader receipt expansion finds a real opposing fact._", "claim_id": "claim_4"}, {"candidate_sources": [{"doi": "10.1002/ijc.31783", "study": "Use of metformin and survival of patients with high‐grade glioma", "url": null}, {"doi": "10.1093/brain/awad366", "study": "Metformin in elderly type 2 diabetes mellitus: dose-dependent dementia risk reduction", "url": null}, {"doi": "10.3389/fmed.2021.640785", "study": "Association Between Preadmission Metformin Use and Outcomes in Intensive Care Unit Patients With Sepsis and Type 2 Diabetes: A Cohort Study", "url": null}, {"doi": "10.1016/j.aohep.2019.10.005", "study": "Metformin in the prevention of hepatocellular carcinoma in diabetic patients: A systematic review", "url": null}, {"doi": "10.3389/fmed.2021.704666", "study": "Metformin in Patients With COVID-19: A Systematic Review and Meta-Analysis", "url": null}], "claim": "Suggested citation:** Dom Lynch. (2026). Stage-Specific Efficacy of Metformin in High-Grade Glioma. ReseaRka Evidence Index. Version 1.0.", "claim_id": "claim_5"}, {"candidate_sources": [{"doi": "10.1002/ijc.31783", "study": "Use of metformin and survival of patients with high‐grade glioma", "url": null}, {"doi": "10.1093/brain/awad366", "study": "Metformin in elderly type 2 diabetes mellitus: dose-dependent dementia risk reduction", "url": null}, {"doi": "10.3389/fmed.2021.640785", "study": "Association Between Preadmission Metformin Use and Outcomes in Intensive Care Unit Patients With Sepsis and Type 2 Diabetes: A Cohort Study", "url": null}, {"doi": "10.1016/j.aohep.2019.10.005", "study": "Metformin in the prevention of hepatocellular carcinoma in diabetic patients: A systematic review", "url": null}, {"doi": "10.3389/fmed.2021.704666", "study": "Metformin in Patients With COVID-19: A Systematic Review and Meta-Analysis", "url": null}], "claim": "Priority note:** This memo records the first published framing, source bundle, and evidence receipts for this run. Reuse should cite the canonical version.", "claim_id": "claim_6"}]}

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