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source_d9c33d4076b94ae4

sha256 811266f9fe00a6a133fca6835958afab97564f7ddc8d3b224d17e72893f6892b

by researka:v2 · 2026-08-22 21:13:31.356416+04:00

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "9be40a10-b14d-4e4a-afff-f058a818c80b", "sources": [{"directness": "direct", "doi": "10.1016/j.eclinm.2025.103633", "risk_of_bias": "not appraised in public sidecar", "study": "Effects of nicotinamide riboside on NAD+ levels, cognition, and symptom recovery in long-COVID: a randomized controlled trial"}, {"directness": "direct", "doi": "10.1002/lary.70173", "risk_of_bias": "not appraised in public sidecar", "study": "NAD+ Enhanced on Hearing Recovery in Sudden Sensorineural Hearing Loss: Randomized Controlled Trial"}, {"directness": "direct", "doi": "10.1186/s12882-020-02006-1", "risk_of_bias": "not appraised in public sidecar", "study": "Nicotinamide riboside with pterostilbene (NRPT) increases NAD + in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI"}, {"directness": "direct", "doi": "10.1007/s40256-025-00764-7", "risk_of_bias": "not appraised in public sidecar", "study": "Effect of Nicotinamide Adenine Dinucleotide on Heart Failure Caused by Ischemic Cardiomyopathy: A Randomized, Placebo-Controlled Trial"}, {"directness": "direct", "doi": "10.1093/jn/nxab193", "risk_of_bias": "not appraised in public sidecar", "study": "NAD + -Precursor Supplementation With L-Tryptophan, Nicotinic Acid, and Nicotinamide Does Not Affect Mitochondrial Function or Skeletal Muscle Function in Physically Compromised Older Adults"}, {"directness": "indirect", "doi": "10.1038/s41598-024-63031-w", "risk_of_bias": "not appraised in public sidecar", "study": "A randomized, controlled clinical trial demonstrates improved owner-assessed cognitive function in senior dogs receiving a senolytic and NAD+ precursor combination"}, {"directness": "direct", "doi": "10.3390/nu14112219", "risk_of_bias": "not appraised in public sidecar", "study": "A Combination of Nicotinamide and D-Ribose (RiaGev) Is Safe and Effective to Increase NAD + Metabolome in Healthy Middle-Aged Adults: A Randomized, Triple-Blind, Placebo-Controlled, Cross-Over Pilot Clinical Trial"}, {"directness": "direct", "doi": "10.3390/ijerph17124215", "risk_of_bias": "not appraised in public sidecar", "study": "Effect of C242T Polymorphism in the Gene Encoding the NAD(P)H Oxidase p22 phox Subunit and Aerobic Fitness Levels on Redox State Biomarkers and DNA Damage Responses to Exhaustive Exercise: A Randomized Trial"}, {"directness": "direct", "doi": "10.1002/trc2.70278", "risk_of_bias": "not appraised in public sidecar", "study": "A combination of ketones and NAD + precursor preserves white matter integrity in mild cognitive impairment"}, {"directness": "direct", "doi": "10.1038/s41598-023-29787-3", "risk_of_bias": "not appraised in public sidecar", "study": "Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial"}, {"directness": "direct", "doi": "10.31083/j.rcm2508297", "risk_of_bias": "not appraised in public sidecar", "study": "Effects of Nicotinamide Adenine Dinucleotide on Older Patients with Heart Failure"}, {"directness": "direct", "doi": "10.1096/fba.2025-00014", "risk_of_bias": "not appraised in public sidecar", "study": "Oral MIB‐626 (β Nicotinamide Mononucleotide) Safely Raises Blood Nicotinamide Adenine Dinucleotide Levels in Hospitalized Patients With COVID‐19 and Acute Kidney Injury: A Randomized Controlled Trial"}, {"directness": "indirect", "doi": "10.1016/j.psj.2026.106931", "risk_of_bias": "not appraised in public sidecar", "study": "Comparative lipidomics and NAD⁺ metabolism in pectoris muscle reveal a lean metabolic phenotype in Daweishan miniature chickens versus arbor acre broilers"}, {"directness": "direct", "doi": "10.1111/acel.13754", "risk_of_bias": "not appraised in public sidecar", "study": "Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin"}, {"directness": "direct", "doi": "10.1371/journal.pone.0186459", "risk_of_bias": "not appraised in public sidecar", "study": "An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers"}, {"directness": "direct", "doi": "10.1038/s41467-018-03421-7", "risk_of_bias": "not appraised in public sidecar", "study": "Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD + in healthy middle-aged and older adults"}, {"directness": "direct", "doi": "10.1016/j.celrep.2019.07.043", "risk_of_bias": "not appraised in public sidecar", "study": "Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD + Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures"}]}
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}

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