Derivation Web

source_dac236c446074cad

by researka:v2 · 2026-06-01 12:05:36.936932+04:00

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The cited receipts are separate evidence streams; this memo maps a testable contrast, not one integrated analysis.", "type": "claim"}, {"id": "claim_2", "text": "Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication.", "type": "claim"}, {"id": "claim_3", "text": "The evidence reveals a paradox: while plant-based diets are associated with reduced mortality and cognitive decline, the risk increase from unhealthful plant-based patterns suggests that biological age modulation depends on dietary quality, not merely plant-based status. This nuanced perspective challenges the simplistic 'plant-based is good' narrative and highlights the need to dissect specific components affecting aging biomarkers.", "type": "claim"}, {"id": "claim_4", "text": "Known / obvious (do not republish): Plant-based diets reduce cardiovascular disease risk (fact 2, 5); Plant-based diets lower all-cause mortality (fact 1); Healthful plant-based diets decrease CVD incidence (fact 7)", "type": "claim"}, {"id": "claim_5", "text": "Real tension: Healthful plant-based diets (hPDI) decrease CVD incidence (fact 7) while unhealthful plant-based diets (uPDI) increase cardiovascular mortality (fact 15)", "type": "claim"}, {"id": "claim_6", "text": "Bounded research question:** Does the cited receipt bundle still support this bounded claim when population, endpoint, comparator, and time window are aligned?", "type": "claim"}, {"id": "claim_7", "text": "`fact_id=140665` (`A_core`) — unhealthful plant-based diets were associated with increased risk of cardiovascular mortality (pooled HR: 1.05, 95% CI: 1.01-1.09) doi=10.3389/fcvm.2021.756810", "type": "claim"}, {"id": "claim_8", "text": "`fact_id=140662` (`A_core`) — Greater adherence to an overall plant-based dietary pattern was significantly associated with a lower risk of cardiovascular mortality (pooled HR: 0.92, 95% CI: 0.86-0.99) doi=10.3389/fcvm.2021.756810", "type": "claim"}, {"id": "claim_9", "text": "`fact_id=140664` (`A_core`) — healthful plant-based diets were associated with decreased CVD incidence (pooled HR: 0.87, 95% CI: 0.80-0.95) doi=10.3389/fcvm.2021.756810", "type": "claim"}, {"id": "claim_10", "text": "`fact_id=76428` (`A_core`) — Higher adherence to a healthy plant-based diet index was associated with a 19% lower risk of cardiovascular disease mortality doi=10.1161/jaha.119.012865", "type": "claim"}, {"id": "claim_11", "text": "`fact_id=97306` (`A_core`) — Lower PDI were associated with an increased risk of cognitive impairment (HR = 1.32; 95% CI 1.16-1.50) doi=10.3390/nu14153132", "type": "claim"}, {"id": "claim_12", "text": "`fact_id=76427` (`A_core`) — participants in the highest versus lowest quintile for adherence to overall plant-based diet index had a 18% to 25% lower risk of all-cause mortality doi=10.1161/jaha.119.012865", "type": "claim"}, {"id": "claim_13", "text": "`fact_id=76425` (`A_core`) — participants in the highest versus lowest quintile for adherence to overall plant-based diet index had a 16% lower risk of cardiovascular disease doi=10.1161/jaha.119.012865", "type": "claim"}, {"id": "claim_14", "text": "`fact_id=76426` (`A_core`) — participants in the highest versus lowest quintile for adherence to overall plant-based diet index had a 31% to 32% lower risk of cardiovascular disease mortality doi=10.1161/jaha.119.012865", "type": "claim"}, {"id": "claim_15", "text": "`fact_id=76429` (`A_core`) — Higher adherence to a healthy plant-based diet index was associated with a 11% lower risk of all-cause mortality doi=10.1161/jaha.119.012865", "type": "claim"}, {"id": "claim_16", "text": "`fact_id=140663` (`A_core`) — lower risk of CVD incidence (pooled HR: 0.90, 95% CI: 0.82-0.98) doi=10.3389/fcvm.2021.756810", "type": "claim"}, {"id": "claim_17", "text": "`fact_id=97307` (`A_core`) — Lower hPDI were associated with an increased risk of cognitive impairment (HR = 1.46; 95% CI 1.29-1.66) doi=10.3390/nu14153132", "type": "claim"}, {"id": "claim_18", "text": "`fact_id=92995` (`A_core`) — plant-based diets may reduce the risk of coronary heart disease events by an estimated 40% doi=10.3390/nu9080848", "type": "claim"}, {"id": "claim_19", "text": "_Within the currently bound receipt bundle, no A_core/B_context opposing fact was selected. Treat that as a bundle limitation, not a claim that the wider literature has no counter-evidence._", "type": "claim"}, {"comparator": "not extracted", "directness": "review-level", "doi": "10.3389/fcvm.2021.756810", "effect": "not extracted", "endpoint": "not extracted", "id": "source_1", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "The Association of Plant-Based Diet With Cardiovascular Disease and Mortality: A Meta-Analysis and Systematic Review of Prospect Cohort Studies", "type": "source", "url": null, "year": 2021}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1161/jaha.119.012865", "effect": "not extracted", "endpoint": "not extracted", "id": "source_2", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Plant‐Based Diets Are Associated With a Lower Risk of Incident Cardiovascular Disease, Cardiovascular Disease Mortality, and All‐Cause Mortality in a General Population of Middle‐Aged Adults", "type": "source", "url": null, "year": 2019}, {"comparator": "not extracted", "directness": "primary", "doi": "10.3390/nu14153132", "effect": "not extracted", "endpoint": "not extracted", "id": "source_3", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Association of Body Mass Index and Plant-Based Diet with Cognitive Impairment among Older Chinese Adults: A Prospective, Nationwide Cohort Study", "type": "source", "url": null, "year": 2022}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1038/s41591-025-03570-5", "effect": "not extracted", "endpoint": "not extracted", "id": "source_4", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Optimal dietary patterns for healthy aging", "type": "source", "url": null, "year": 2025}, {"comparator": "not extracted", "directness": "primary", "doi": "10.3390/nu9080848", "effect": "not extracted", "endpoint": "not extracted", "id": "source_5", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Cardio-Metabolic Benefits of Plant-Based Diets", "type": "source", "url": null, "year": 2017}], "publication_id": "04a35127-e5b9-48ec-b983-78664c49140e", "screening": {"excluded": 0, "exclusion_reasons": ["No PRISMA full-text exclusion-stage filter was applied."], "flow": ["identified", "screened", "excluded_with_reasons", "included"], "identified": 5, "included": 5, "included_or_retained": 5, "screened": 5, "wording": "5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit."}}

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