Derivation Web

source_dcdd9aa28ea84750

by researka:v2 · 2026-06-20 16:56:32.924226+04:00

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Determinants of heritable gene silencing for KRAB-dCas9 + DNMT3 and Ezh2-dCas9 + DNMT3 hit-and-run epigenome editing,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Interrogation of enhancer function by enhancer-targeting CRISPR epigenetic editing,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
A modular dCas9-based recruitment platform for combinatorial epigenome editing,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Expanded CAG/CTG repeats resist gene silencing mediated by targeted epigenome editing,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Chem-CRISPR/dCas9 FCPF : a platform for chemically induced epigenome editing,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Programmable epigenome editing by transient delivery of CRISPR epigenome editor ribonucleoproteins,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Rescue of imprinted genes by epigenome editing in human cellular models of Prader-Willi syndrome,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Locus-Specific and Stable DNA Demethylation at the H19 / IGF2 ICR1 by Epigenome Editing Using a dCas9-SunTag System and the Catalytic Domain of TET1,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Targeted DNA demethylation of the Fgf21 promoter by CRISPR/dCas9-mediated epigenome editing,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Efficient generation of epigenetic disease model mice by epigenome editing using the piggyBac transposon system,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Engineered Cas9 variants bypass Keap1-mediated degradation in human cells and enhance epigenome editing efficiency,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
A Modular and Customizable CRISPR/Cas Toolkit for Epigenome Editing of Cis ‐regulatory Modules,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Investigating crosstalk between H3K27 acetylation and H3K4 trimethylation in CRISPR/dCas-based epigenome editing and gene activation,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Predicting the effect of CRISPR-Cas9-based epigenome editing,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
A modular dCas9-SunTag DNMT3A epigenome editing system overcomes pervasive off-target activity of direct fusion dCas9-DNMT3A constructs,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Concurrent genome and epigenome editing by CRISPR-mediated sequence replacement,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Studenski 2011,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Cesari 2009,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
ADA 2024,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Cruz-Jentoft 2019,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Anisimov 2008,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Tinetti 1988,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Tancredi 2015,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Ioannidis 2005,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation

{
  "researka_object_type": "publication_sidecar",
  "researka_publication_id": "f7b01234-38e2-4b03-b28b-707000e0635b",
  "researka_submission_id": "9ca0f27b-2eff-4511-98e4-d1b779f7da9d",
  "sidecar_name": "evidence_table.csv",
  "sidecar_url": "https://api.researka.org/publications/f7b01234-38e2-4b03-b28b-707000e0635b/sidecars/evidence_table.csv"
}