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# Hypothesis-Generating Brief: Metformin Monotherapy Effects — full paper
## Abstract

Evidence-honesty note: 16/19 retained sources are indirect, review-level, adjacent, or mechanistic and are used only to bound interpretation. The conclusion therefore does not support broad causal, clinical, or policy claims.

This paper synthesizes evidence on metformin monotherapy effects across 19 included so…
sha256 7fe921b5987ea247…