Derivation Web

source_df625103c6f94550

by researka:v2 · 2026-06-28 04:45:41.786872+04:00

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Shorter telomere length as a prognostic marker for survival and recurrence in breast cancer: a systematic review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Telomere lengths in women treated for breast cancer show associations with chemotherapy, pain symptoms, and cognitive domain measures: a longitudinal study",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"A Natural Astragalus-Based Nutritional Supplement Lengthens Telomeres in a Middle-Aged Population: A Randomized, Double-Blind, Placebo-Controlled Study",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"The association of epigenetic age acceleration with internal smoking dose, risk of lung cancer, and all-cause mortality in cigarette smokers: the Multiethnic Cohort study",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Systematic review of Mendelian randomization studies on risk of cancer,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Aging and increased cancer risk: exploring the potential of LE8 score to mitigate risk,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Lymphoid malignancy and clonality in the POT1-mediated long telomere syndrome ∗,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Leukocyte telomere attrition following radiotherapy in prostate cancer: a prospective study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Effect of Traditional Korean Medicine Oncotherapy on the Survival, Quality of Life, and Telomere Length: A Prospective Cohort Study",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Unraveling the telomere-mitochondrial axis in colorectal cancer: Results from a prospectively followed cohort,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Integrative Analysis of Telomere‐Related Genes Reveals Prognostic Signatures in Laryngeal Cancer,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Leukocyte Telomere Length Variants Are Independently Associated with Survival of Patients with Colorectal Cancer,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"DNA methylation‐based telomere length is associated with HIV infection, physical frailty, cancer, and all‐cause mortality",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Associations between telomere attrition, genetic variants in telomere maintenance genes, and non-small cell lung cancer risk in the Jammu and Kashmir population of North India",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
SMARCAL1 is a targetable synthetic lethal therapeutic vulnerability in ATRX-deficient gliomas that use alternative lengthening of telomeres,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Association between genetically determined telomere length and health‐related outcomes: A systematic review and meta‐analysis of Mendelian randomization studies,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Telomerase Activity in Melanoma: Impact on Cancer Cell Proliferation Kinetics, Tumor Progression, and Clinical Therapeutic Strategies—A Scoping Review",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
ZEB1 Promotes Alternate Lengthening of Telomeres at Multiple Levels,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Mendelian randomization study on the causal relationship between leukocyte telomere length and prostate cancer,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The Association between Telomere Length and Head and Neck Cancer Risk: A Systematic Review and Meta-Analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Association Between Telomere Length and Skin Cancer and Aging: A Mendelian Randomization Analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Integrative Bulk and Single-Cell Transcriptome Profiling of Telomere-Related Genes Reveals a Robust Prognostic Signature and Immunotherapeutic Landscape in Neuroblastoma,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Telomere-driven dysfunctional changes in gynecological cancers: mechanistic insights, biomarker potential, and therapeutic targeting",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Identification of telomere-related lncRNAs and immunological analysis in ovarian cancer,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The impact of adjuvant chemotherapy in older breast cancer patients on clinical and biological aging parameters,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation

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