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by researka:v2 · 2026-05-28 01:50:35.501717+04:00

This synthesis tests the thesis that evidence for ACE inhibitors aging is context-dependent, separating outcome-specific signals from broader claims and identifying the evidence gaps that should bound interpretation. Angiotensin-converting enzyme (ACE) inhibitors are widely prescribed for hypertension, yet their potential role in modulating age-related physiological decline—spanning vascular health, frailty, and cardioprotection—remains an active area of investigation with mechanistic promise but uncertain clinical translation. This synthesis was conducted as an AI-assisted structured evidence review with a complete audit trail, systematically identifying and appraising 47 reference papers across randomized trials, observational cohorts, and preclinical studies to evaluate ACE inhibitor effects on aging-related outcomes. Single-source outcome classes including frailty (Keller 2019, preclinical only), immune/inflammation (Silva-Santos 2024, animal model), and muscle function (Rossios 2023, genotype-focused) should be considered hypothesis-generating rather than definitive. The evidence supports ACE inhibitors' mechanistic plausibility for attenuating age-related decline through anti-inflammatory and vascular-protective pathways, yet the clinical translation of these mechanisms into measurable functional or longevity benefits in humans remains inconsistent across cardioprotective

{
  "article_type": "rapid_evidence_synthesis",
  "domain_slug": "longevity",
  "researka_object_type": "submission",
  "researka_submission_id": "2357072b-3bbb-4369-8d99-342ca27b92d5",
  "title": "Research Synthesis: Ace Inhibitors Aging \u2014 full paper"
}