source · application/json
source_e6275c914f1c44ac
sha256 b03969f39231d631132b1b3f2904e69910857b46cdab7f17be7b4f83b9390312
by researka:v2 · 2026-07-02 12:52:22.656740+04:00
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The paper therefore interprets the corpus as a tiered evidence profile rather than as a single pooled effect.", "type": "claim"}, {"id": "claim_4", "text": "The conclusion is that aerobic exercise training effects remains a bounded evidence case: the retained direct, adjacent, and context evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified broad clinical claim.", "type": "claim"}, {"id": "claim_5", "text": "For that reason, the manuscript does not collapse every source into a single recommendation. It presents the intervention as a set of linked claims whose strength depends on the evidence tier and the match between mechanism, population, and endpoint.", "type": "claim"}, {"id": "claim_6", "text": "This synthesis evaluates evidence on aerobic exercise training effects across 39 included source papers and 1715 high-confidence extracted claims. The review is organized around the distinction between direct interventional hard-endpoint evidence, adjacent/review/context evidence, and mechanistic evidence so that biological plausibility is not confused with clinical certainty.", "type": "claim"}, {"id": "claim_7", "text": "The corpus contains 13 direct clinical sources, 26 adjacent, review, or context sources, and no sources classified primarily as mechanistic or model-system evidence. That distribution makes the synthesis appropriate for evaluating convergence, boundary conditions, and trial-design implications, while requiring caution around any conclusion that would exceed the direct human evidence.", "type": "claim"}, {"id": "claim_8", "text": "The introductory frame therefore treats the corpus as a set of evidence roles rather than a single directional verdict. Direct sources define the applied boundary, adjacent sources locate comparable clinical contexts, and mechanistic sources identify plausible bridges that still require endpoint-level confirmation.", "type": "claim"}, {"id": "claim_9", "text": "This distinction matters for publication because it makes the paper falsifiable. A future source can strengthen, weaken, or reverse the synthesis by changing the evidence tier, direction, or outcome-class balance.", "type": "claim"}, {"id": "claim_10", "text": "The mechanistic layer is most useful when it explains why a trial signal might appear or fail to appear. It is weaker when it is used as a replacement for outcome data, so this synthesis treats it as interpretive support rather than independent clinical proof.", "type": "claim"}, {"id": "claim_11", "text": "Null findings have a specific role in this evidence model. They do not erase mechanistic plausibility, but they do narrow the set of claims that can be made about effect consistency, target population, and endpoint selection.", "type": "claim"}, {"id": "claim_12", "text": "Adverse or negative signals are likewise retained in the main interpretation. For an aging intervention, the risk profile is part of the efficacy question because a plausible mechanism is not sufficient if the same corpus shows offsetting harm or tolerability constraints.", "type": "claim"}, {"id": "claim_13", "text": "The evidence base also distinguishes breadth from certainty. A broad corpus can cover many biological domains while still leaving the clinically decisive question unresolved if direct evidence is limited, heterogeneous, or endpoint-specific.", "type": "claim"}, {"id": "claim_14", "text": "The research value of the synthesis lies in making these boundaries explicit. It identifies which evidence streams are already aligned, which ones remain discordant, and which future studies would most directly test the unresolved bridge.", "type": "claim"}, {"id": "claim_15", "text": "The background evidence for aerobic exercise training effects is heterogeneous rather than uniformly confirmatory. Direct clinical sources such as MoralesPalomo 2023, Kleinloog 2022, Sloan 2018 are interpreted separately from mechanistic studies such as the retained evidence base, because these evidence roles answer different questions about aging biology and clinical translation.", "type": "claim"}, {"id": "claim_16", "text": "The direct evidence establishes what has been observed in human or adjacent clinical settings. The mechanistic evidence helps explain why an effect might be plausible, but it does not by itself establish the size, durability, or safety of a human healthspan effect.", "type": "claim"}, {"id": "claim_17", "text": "Across the retained sources, positive signals cluster around the cardiometabolic, contextual adjacent evidence and muscle function outcome classes; null signals around the contextual adjacent evidence, cardiometabolic and muscle function outcome classes; and negative or adverse signals around the cardiometabolic outcome class. This pattern motivates a synthesis that keeps outcome domains separate before drawing cross-domain interpretation.", "type": "claim"}, {"id": "claim_18", "text": "The study-level structure also prevents selective emphasis. Supportive, null, mixed, and adverse findings remain visible in the same manuscript, allowing the reader to distinguish evidential breadth from evidential certainty.", "type": "claim"}, {"id": "claim_19", "text": "The resulting paper is therefore a calibrated synthesis: it can identify plausible mechanisms, observed direct signals when present, unresolved tensions, and trial-design priorities without converting them into claims stronger than the retained corpus can support.", "type": "claim"}, {"id": "claim_20", "text": "The following fields were extracted from each included source: study design, population / cohort, intervention or exposure, comparator, outcome class, effect direction, effect size, confidence interval or credible interval, p-value, sample size, follow-up duration, risk-of-bias rating. Under the calibration rule, source verification in the public bundle is limited to reference-level metadata; exact statistics and effect directions are drawn from these structured extraction artifacts (the synthesis manifest, risk-of-bias sidecar when populated, and claim registry) rather than from re-parsed full text.", "type": "claim"}, {"id": "claim_21", "text": "Risk-of-bias framework assignment follows study design (RoB-2 for RCTs, ROBINS-I for non-randomised studies, AMSTAR-2 for systematic reviews / meta-analyses). Public appraisal claims are limited to populated `risk_of_bias.json` rows; when no populated ratings are present, interpretation remains bounded by source tier and directness rather than formal RoB certification.", "type": "claim"}, {"id": "claim_22", "text": "Evidence-tension synthesis: claims grouped by outcome class (cardiometabolic, contextual adjacent evidence, deficiency prevalence, immune and inflammation, muscle function, safety and comorbidity); within-class agreement, disagreement, and directness gaps surfaced explicitly. Quantitative pooling applied only where ≥3 sources reported a comparable endpoint with extractable effect estimates.", "type": "claim"}, {"id": "claim_23", "text": "Source retrieval, claim extraction, evidence routing, and prose drafting were assisted by large language models under a deterministic audit-trail protocol. Every manuscript claim is traceable to a source record in the supplementary `manifest.json`. Final eligibility and interpretation decisions are author-verified.", "type": "claim"}, {"id": "claim_24", "text": "Directional coding note: Null or no extracted directional signal means no coded positive, negative, or mixed effect was extracted for that specific outcome class; it is not an absence-of-support finding. Positive, negative, mixed, unclear, and null are outcome-specific codes, so a bounded rationale can be supported by adjacent or different outcome evidence while another outcome remains null or unclear. Contextual claims contain bibliographic background, mechanism, methods, exposure definitions, or population context rather than effect-direction evidence. When an outcome-class summary uses no extracted directional signal, it should state the source proportion, such as X/Y sources, to avoid ambiguity. Majority-direction note: 19/39 retained sources are coded unclear at the receipt level. Unless the extraction records a positive, negative, mixed, or null polarity for the mapped outcome, the manuscript states that direction cannot be determined for that source and narrows the conclusion instead of treating source count as directional support. Directional-map boundary: Because 19/39 retained sources are predominantly unclear-coded at receipt level, the corpus does not support a standalone per-class directional map; source-level p-values and polarity are reported as audit facts rather than efficacy directions unless extraction records polarity.", "type": "claim"}, {"id": "claim_25", "text": "Findings Map accounting note: each outcome-class n, direction count, directness count, and source roster is computed from the same source-level rows listed in the detailed table. Receipt-level direction is not a statement that the source abstracts lack directional statistics; it is the conservative coded polarity used for synthesis accounting. Outcome-class roster: Cardiometabolic n=15 (direction: negative=1; null=4; positive=3; unclear=7; directness: direct=3; indirect=4; protocol=1; review=7; sources: Alzahrani 2023; Burchert 2022; Ding 2025; Gelinas 2017; Han 2016; Healy 2024; Konopka 2019; Li 2024; MoralesPalomo 2023; Prior 2014; Rajabi 2024; Silva 2023; Swift 2012; Tanaka 2018; Wyngaert 2018); Contextual Adjacent Evidence n=13 (direction: negative=2; null=4; positive=1; unclear=6; directness: direct=5; indirect=5; review=3; sources: Bakali 2023; Davis 2017; Ehlers 2025; Gaitan 2021; Hansen 2021; Hugenschmidt 2019; Kleinloog 2022; Kobayashi 2021; Morita 2019; Pawar 2025; Raichlen 2020; Wood 2023; Zhou 2026); Muscle Function n=5 (direction: null=3; positive=1; unclear=1; directness: direct=3; indirect=2; sources: Alkhateeb 2020; Jannas-Vela 2023; Liu-Ambrose 2010; Lo 2021; Santos 2024); Immune and Inflammation n=3 (direction: mixed=1; null=1; unclear=1; directness: direct=1; indirect=1; review=1; sources: Emmel 2025; Ghojazadeh 2024; Sloan 2018); Safety and Comorbidity n=2 (direction: null=2; directness: direct=1; indirect=1; sources: Jespersen 2023; Oliveira 2018); Deficiency Prevalence n=1 (direction: unclear=1; directness: review=1; sources: ZURE 2025).", "type": "claim"}, {"id": "claim_26", "text": "| Evidence domain | Source | Direction | Directness | Tier | Evidence role | Finding |", "type": "claim"}, {"id": "claim_27", "text": "| Cardiometabolic | Burchert 2022: Aerobic Exercise Training Response in Preterm-Born Young Adults with Elevated Blood Pressure and Stage 1 Hypertension: A Randomized Clinical Trial | direction=unclear | directness=direct | A1 | outcome=Cardiometabolic; direction=unclear | finding=representative non-significant statistic P = 0.32; not treated as positive or negative directional support unless source direction is coded |", "type": "claim"}, {"id": "claim_28", "text": "| Cardiometabolic | Gelinas 2017: Aerobic exercise training does not alter vascular structure and function in chronic obstructive pulmonary disease. | direction=null | directness=review | B1 | outcome=Cardiometabolic; direction=null | finding=2 extracted claim(s); receipt-level direction is the coded finding |", "type": "claim"}, {"id": "claim_29", "text": "| Cardiometabolic | Li 2024: The effect of moderate and vigorous aerobic exercise training on the cognitive and walking ability among stroke patients during different periods: A systematic review and meta-analysis | direction=null | directness=review | B2 | outcome=Cardiometabolic; direction=null | finding=12 extracted claim(s); receipt-level direction is the coded finding |", "type": "claim"}, {"id": "claim_30", "text": "| Cardiometabolic | Prior 2014: Increased Skeletal Muscle Capillarization After Aerobic Exercise Training and Weight Loss Improves Insulin Sensitivity in Adults With IGT | direction=positive | directness=indirect | B2 | outcome=Cardiometabolic; direction=positive | finding=representative statistic P < 0.05; source-level statistic reported |", "type": "claim"}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1113/JP285366", "effect": "not extracted", "endpoint": "not extracted", "id": "source_1", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Efficacy of morning versus afternoon aerobic exercise training on reducing metabolic syndrome components: A randomized controlled trial", "type": "source", "url": "https://doi.org/10.1113/JP285366", "year": 2023}, {"comparator": "not extracted", "directness": "primary", "doi": "10.14814/phy2.15395", "effect": "not extracted", "endpoint": "not extracted", "id": "source_2", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Aerobic exercise training improves not only brachial artery flow‐mediated vasodilatation but also carotid artery reactivity: A randomized controlled, cross‐over trial in older men", "type": "source", "url": "https://doi.org/10.14814/phy2.15395", "year": 2022}, {"comparator": "not extracted", "directness": "review-level", "doi": "10.1186/s40798-025-00918-6", "effect": "not extracted", "endpoint": "not extracted", "id": "source_3", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Effects of Aerobic Exercise Training in Hypoxia Versus Normoxia on Body Composition and Metabolic Health in Overweight and/or Obese Populations: an Updated Meta-Analysis", "type": "source", "url": "https://doi.org/10.1186/s40798-025-00918-6", "year": 2025}, {"comparator": "not extracted", "directness": "review-level", "doi": "10.1002/ejsc.12125", "effect": "not extracted", "endpoint": "not extracted", "id": "source_4", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "The effect of 12 weeks of aerobic exercise training with or without saffron supplementation on diabetes‐specific markers and inflammation in women with type 2 diabetes: A randomized double‐blind placebo‐controlled trial", "type": "source", "url": "https://doi.org/10.1002/ejsc.12125", "year": 2024}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1038/s41598-025-13905-4", "effect": "not extracted", "endpoint": "not extracted", "id": "source_5", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Feasibility of an unsupervised aerobic exercise training program for participants with persistent symptoms after SARS-CoV-2 infection", "type": "source", "url": "https://doi.org/10.1038/s41598-025-13905-4", "year": 2025}, {"comparator": "not extracted", "directness": "primary", "doi": "10.3390/medicina59061171", "effect": "not extracted", "endpoint": "not extracted", "id": "source_6", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Feasibility and Efficacy of Low-to-Moderate Intensity Aerobic Exercise Training in Reducing Resting Blood Pressure in Sedentary Older Saudis with Hypertension Living in Social Home Care: A Pilot Randomized Controlled Trial", "type": "source", "url": "https://doi.org/10.3390/medicina59061171", "year": 2023}, {"comparator": "not extracted", "directness": "primary", "doi": "10.3390/nu13103498", "effect": "not extracted", "endpoint": "not extracted", "id": "source_7", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "The Effect of Aerobic Exercise Training Frequency on Arterial Stiffness in a Hyperglycemic State in Middle-Aged and Elderly Females", "type": "source", "url": "https://doi.org/10.3390/nu13103498", "year": 2021}, {"comparator": "not extracted", "directness": "review-level", "doi": "10.1186/s40798-024-00781-x", "effect": "not extracted", "endpoint": "not extracted", "id": "source_8", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "The Effects of Aerobic Exercise Training on Testosterone Concentration in Individuals Who are Obese or Have Type 2 Diabetes: A Systematic Review and Meta-Analysis", "type": "source", "url": "https://doi.org/10.1186/s40798-024-00781-x", "year": 2024}, {"comparator": "not extracted", "directness": "primary", "doi": "10.3390/ijerph18010101", "effect": "not extracted", "endpoint": "not extracted", "id": "source_9", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Effects of Individualized Aerobic Exercise Training on Physical Activity and Health-Related Physical Fitness among Middle-Aged and Older Adults with Multimorbidity: A Randomized Controlled Trial", "type": "source", "url": "https://doi.org/10.3390/ijerph18010101", "year": 2021}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1164/rccm.202205-0858OC", "effect": "not extracted", "endpoint": "not extracted", "id": "source_10", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Aerobic Exercise Training Response in Preterm-Born Young Adults with Elevated Blood Pressure and Stage 1 Hypertension: A Randomized Clinical Trial", "type": "source", "url": "https://doi.org/10.1164/rccm.202205-0858OC", "year": 2022}, {"comparator": "not extracted", "directness": "review-level", "doi": "10.1007/s40279-023-01817-0", "effect": "not extracted", "endpoint": "not extracted", "id": "source_11", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Estimating the Effect of Aerobic Exercise Training on Novel Lipid Biomarkers: A Systematic Review and Multivariate Meta-Analysis of Randomized Controlled Trials", "type": "source", "url": "https://doi.org/10.1007/s40279-023-01817-0", "year": 2023}, {"comparator": "not extracted", "directness": "review-level", "doi": "10.1136/openhrt-2023-002384", "effect": "not extracted", "endpoint": "not extracted", "id": "source_12", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Effect of aerobic exercise training on pulse wave velocity in adults with and without long-term conditions: a systematic review and meta-analysis", "type": "source", "url": "https://doi.org/10.1136/openhrt-2023-002384", "year": 2023}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1152/ajpheart.00132.2024", "effect": "not extracted", "endpoint": "not extracted", "id": "source_13", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Aerobic exercise training combined with local strength exercise restores muscle blood flow and maximal aerobic capacity in long-term Hodgkin lymphoma survivors", "type": "source", "url": "https://doi.org/10.1152/ajpheart.00132.2024", "year": 2024}, {"comparator": "not extracted", "directness": "primary", "doi": "10.3389/fendo.2021.660181", "effect": "not extracted", "endpoint": "not extracted", "id": "source_14", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer’s Disease", "type": "source", "url": "https://doi.org/10.3389/fendo.2021.660181", "year": 2021}, {"comparator": "not extracted", "directness": "review-level", "doi": "10.23736/S1973-9087.25.08817-3", "effect": "not extracted", "endpoint": "not extracted", "id": "source_15", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "The effect of blood flow restricted aerobic exercise training on pain, functional status, quality of life and hormonal response to exercise in fibromyalgia patients: a randomized double-blind study", "type": "source", "url": "https://doi.org/10.23736/S1973-9087.25.08817-3", "year": 2025}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1186/s13063-023-07694-2", "effect": "not extracted", "endpoint": "not extracted", "id": "source_16", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Anodal transcranial direct current stimulation associated with aerobic exercise on the functional and physical capacity of patients with heart failure with reduced ejection fraction: ELETRIC study protocol", "type": "source", "url": "https://doi.org/10.1186/s13063-023-07694-2", "year": 2023}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1136/bmjopen-2021-049477", "effect": "not extracted", "endpoint": "not extracted", "id": "source_17", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Effect of aerobic exercise training on asthma control in postmenopausal women (the ATOM-study): protocol for an outcome assessor, randomised controlled trial", "type": "source", "url": "https://doi.org/10.1136/bmjopen-2021-049477", "year": 2021}, {"comparator": "not extracted", "directness": "review-level", "doi": "10.1371/journal.pone.0298339", "effect": "not extracted", "endpoint": "not extracted", "id": "source_18", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "The effect of moderate and vigorous aerobic exercise training on the cognitive and walking ability among stroke patients during different periods: A systematic review and meta-analysis", "type": "source", "url": "https://doi.org/10.1371/journal.pone.0298339", "year": 2024}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1186/s13063-023-07385-y", "effect": "not extracted", "endpoint": "not extracted", "id": "source_19", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Effect of aerobic exercise training on the fat fraction of the liver in persons with chronic hepatitis B and hepatic steatosis: Trial protocol for a randomized controlled intervention trial— The FitLiver study", "type": "source", "url": "https://doi.org/10.1186/s13063-023-07385-y", "year": 2023}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1186/s13063-020-04797-y", "effect": "not extracted", "endpoint": "not extracted", "id": "source_20", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Effects of football versus aerobic exercise training on muscle architecture in healthy men adults: a study protocol of a two-armed randomized controlled trial", "type": "source", "url": "https://doi.org/10.1186/s13063-020-04797-y", "year": 2020}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1136/bmjopen-2025-104378", "effect": "not extracted", "endpoint": "not extracted", "id": "source_21", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Enhancing cognitive function in breast cancer survivors through community-based aerobic exercise training: protocol for a Hybrid Type I effectiveness–implementation study employing a randomised controlled design", "type": "source", "url": "https://doi.org/10.1136/bmjopen-2025-104378", "year": 2025}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1136/bmjopen-2025-103297", "effect": "not extracted", "endpoint": "not extracted", "id": "source_22", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Telemedicine-based individualised aerobic exercise training in Chinese adults with inactive or mildly active inflammatory bowel disease: study protocol for a single-centre, semi-crossover randomised controlled trial", "type": "source", "url": "https://doi.org/10.1136/bmjopen-2025-103297", "year": 2026}, {"comparator": "not extracted", "directness": "review-level", "doi": "10.1007/s00405-025-09436-3", "effect": "not extracted", "endpoint": "not extracted", "id": "source_23", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Effectiveness of aerobic exercise training in patients with obstructive sleep 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"study": "Role of specialized pro-resolving mediators on inflammation, cardiometabolic health, disease progression, and quality of life after omega-3 PUFA supplementation and aerobic exercise training in individuals with rheumatoid arthritis: a randomized 16-week, placebo-controlled interventional trial *", "type": "source", "url": "https://doi.org/10.12688/f1000research.138392.1", "year": 2023}, {"comparator": "not extracted", "directness": "review-level", "doi": "10.1016/j.rmed.2024.107732", "effect": "not extracted", "endpoint": "not extracted", "id": "source_26", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "The effects of aerobic exercise training on inflammatory markers in adult tobacco smokers: A systematic review and meta-analysis of randomized controlled trials.", "type": "source", "url": "https://doi.org/10.1016/j.rmed.2024.107732", "year": 2024}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1161/JAHA.118.010201", "effect": "not extracted", "endpoint": "not extracted", "id": "source_27", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Aerobic Exercise Training and Inducible Inflammation: Results of a Randomized Controlled Trial in Healthy, Young Adults", "type": "source", "url": "https://doi.org/10.1161/JAHA.118.010201", "year": 2018}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1111/acel.12880", "effect": "not extracted", "endpoint": "not extracted", "id": "source_28", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults", "type": "source", "url": "https://doi.org/10.1111/acel.12880", "year": 2019}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1186/s12883-016-0661-9", "effect": "not extracted", "endpoint": "not extracted", "id": "source_29", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Association of serum myokines and aerobic exercise training in patients with spinal cord injury: an observational study", "type": "source", "url": "https://doi.org/10.1186/s12883-016-0661-9", "year": 2016}, {"comparator": "not extracted", "directness": "primary", "doi": "10.2337/dc13-2358", "effect": "not extracted", "endpoint": "not extracted", "id": "source_30", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Increased Skeletal Muscle Capillarization After Aerobic Exercise Training and Weight Loss Improves Insulin Sensitivity in Adults With IGT", "type": "source", "url": "https://doi.org/10.2337/dc13-2358", "year": 2014}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1002/oby.22525", "effect": "not extracted", "endpoint": "not extracted", "id": "source_31", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Cognitive effects of adding caloric restriction to aerobic exercise training in older adults with obesity", "type": "source", "url": "https://doi.org/10.1002/oby.22525", "year": 2019}, {"comparator": "not extracted", "directness": "primary", "doi": "10.5935/abc.20180039", "effect": "not extracted", "endpoint": "not extracted", "id": "source_32", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Safety and Efficacy of Aerobic Exercise Training Associated to Non-Invasive Ventilation in Patients with Acute Heart Failure", "type": "source", "url": "https://doi.org/10.5935/abc.20180039", "year": 2018}, {"comparator": "not extracted", "directness": "review-level", "doi": "10.1371/journal.pone.0203662", "effect": "not extracted", "endpoint": "not extracted", "id": "source_33", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "The effects of aerobic exercise on eGFR, blood pressure and VO 2 peak in patients with chronic kidney disease stages 3-4: A systematic review and meta-analysis", "type": "source", "url": "https://doi.org/10.1371/journal.pone.0203662", "year": 2018}, {"comparator": "not extracted", "directness": "primary", "doi": "10.3390/nu11040868", "effect": "not extracted", "endpoint": "not extracted", "id": "source_34", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Aerobic Exercise Training with Brisk Walking Increases Intestinal Bacteroides in Healthy Elderly Women", "type": "source", "url": "https://doi.org/10.3390/nu11040868", "year": 2019}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1136/bmjopen-2016-014387", "effect": "not extracted", "endpoint": "not extracted", "id": "source_35", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Economic evaluation of aerobic exercise training in older adults with vascular cognitive impairment: PROMoTE trial", "type": "source", "url": "https://doi.org/10.1136/bmjopen-2016-014387", "year": 2017}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1002/ehf2.12285", "effect": "not extracted", "endpoint": "not extracted", "id": "source_36", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "The impact of aerobic exercise training with vascular occlusion in patients with chronic heart failure", "type": "source", "url": "https://doi.org/10.1002/ehf2.12285", "year": 2018}, {"comparator": "not extracted", "directness": "review-level", "doi": "10.1136/bjsports-2011-090025", "effect": "not extracted", "endpoint": "not extracted", "id": "source_37", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "The effect of different doses of aerobic exercise training on endothelial function in postmenopausal women with elevated blood pressure: results from the DREW study.", "type": "source", "url": "https://doi.org/10.1136/bjsports-2011-090025", "year": 2012}, {"comparator": "not extracted", "directness": "review-level", "doi": "10.1113/ep086379", "effect": "not extracted", "endpoint": "not extracted", "id": "source_38", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Aerobic exercise training does not alter vascular structure and function in chronic obstructive pulmonary disease.", "type": "source", "url": "https://doi.org/10.1113/ep086379", "year": 2017}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1186/1471-2377-10-14", "effect": "not extracted", "endpoint": "not extracted", "id": "source_39", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Promotion of the mind through exercise (PROMoTE): a proof-of-concept randomized controlled trial of aerobic exercise training in older adults with vascular cognitive impairment", "type": "source", "url": "https://doi.org/10.1186/1471-2377-10-14", "year": 2010}, {"comparator": "not extracted", "directness": "citation", "doi": null, "effect": "not extracted", "endpoint": "not extracted", "id": "source_40", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.", "type": "source", "url": null, "year": null}, {"comparator": "not extracted", "directness": "citation", "doi": null, "effect": "not extracted", "endpoint": "not extracted", "id": "source_41", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.", "type": "source", "url": null, "year": null}, {"comparator": "not extracted", "directness": "citation", "doi": null, "effect": "not extracted", "endpoint": "not extracted", "id": "source_42", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.", "type": "source", "url": null, "year": null}, {"comparator": "not extracted", "directness": "citation", "doi": null, "effect": "not extracted", "endpoint": "not extracted", "id": "source_43", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.", "type": "source", "url": null, "year": null}, {"comparator": "not extracted", "directness": "citation", "doi": "10.1371/journal.pmed.0020124", "effect": "not extracted", "endpoint": "not extracted", "id": "source_44", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Ioannidis 2005", "type": "source", "url": "https://doi.org/10.1371/journal.pmed.0020124", "year": null}], "publication_id": "32110f91-0ef4-4117-9031-000af0bdab66", "screening": {"excluded": 0, "exclusion_reasons": ["No PRISMA full-text exclusion-stage filter was applied."], "flow": ["identified", "screened", "excluded_with_reasons", "included"], "identified": 39, "included": 39, "included_or_retained": 39, "screened": 39, "wording": "39 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit."}}
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