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sha256 81e0072b3a0711c50ddb7aaf21500f23b61fd2a490e5bb98a9622cf795bbceec

by researka:v2 · 2026-06-25 04:51:43.708696+04:00

{"publication_id": "d3b70206-291b-45c9-b804-ee73aaf10692", "traces": [{"candidate_sources": [{"doi": "10.4236/jdm.2012.21013", "study": "Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats", "url": "https://doi.org/10.4236/jdm.2012.21013"}, {"doi": "10.3390/nu8010027", "study": "Quercetin Attenuates Chronic Ethanol-Induced Hepatic Mitochondrial Damage through Enhanced Mitophagy", "url": "https://doi.org/10.3390/nu8010027"}, {"doi": "10.3390/metabo13010130", "study": "Quercetin, a Plant Flavonol Attenuates Diabetic Complications, Renal Tissue Damage, Renal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Rats", "url": "https://doi.org/10.3390/metabo13010130"}, {"doi": "10.3390/ph17060757", "study": "Quercetin and Kaempferol as Multi-Targeting Antidiabetic Agents against Mouse Model of Chemically Induced Type 2 Diabetes", "url": "https://doi.org/10.3390/ph17060757"}, {"doi": "10.3892/ijmm.2023.5321", "study": "Quercetin alleviates lipopolysaccharide‑induced acute lung injury by inhibiting ferroptosis via the Sirt1/Nrf2/Gpx4 pathway", "url": "https://doi.org/10.3892/ijmm.2023.5321"}], "claim": "Across retrieved fact-level receipts for quercetin, which endpoints show directionally favorable versus null/non-convergent signals, and what matched PICO remains untested?", "claim_id": "claim_1"}, {"candidate_sources": [{"doi": "10.4236/jdm.2012.21013", "study": "Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats", "url": "https://doi.org/10.4236/jdm.2012.21013"}, {"doi": "10.3390/nu8010027", "study": "Quercetin Attenuates Chronic Ethanol-Induced Hepatic Mitochondrial Damage through Enhanced Mitophagy", "url": "https://doi.org/10.3390/nu8010027"}, {"doi": "10.3390/metabo13010130", "study": "Quercetin, a Plant Flavonol Attenuates Diabetic Complications, Renal Tissue Damage, Renal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Rats", "url": "https://doi.org/10.3390/metabo13010130"}, {"doi": "10.3390/ph17060757", "study": "Quercetin and Kaempferol as Multi-Targeting Antidiabetic Agents against Mouse Model of Chemically Induced Type 2 Diabetes", "url": "https://doi.org/10.3390/ph17060757"}, {"doi": "10.3892/ijmm.2023.5321", "study": "Quercetin alleviates lipopolysaccharide‑induced acute lung injury by inhibiting ferroptosis via the Sirt1/Nrf2/Gpx4 pathway", "url": "https://doi.org/10.3892/ijmm.2023.5321"}], "claim": "null/non-convergent or other/mixed: the extracted fact is null, mixed, or not directionally interpretable.", "claim_id": "claim_2"}, {"candidate_sources": [{"doi": "10.4236/jdm.2012.21013", "study": "Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats", "url": "https://doi.org/10.4236/jdm.2012.21013"}, {"doi": "10.3390/nu8010027", "study": "Quercetin Attenuates Chronic Ethanol-Induced Hepatic Mitochondrial Damage through Enhanced Mitophagy", "url": "https://doi.org/10.3390/nu8010027"}, {"doi": "10.3390/metabo13010130", "study": "Quercetin, a Plant Flavonol Attenuates Diabetic Complications, Renal Tissue Damage, Renal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Rats", "url": "https://doi.org/10.3390/metabo13010130"}, {"doi": "10.3390/ph17060757", "study": "Quercetin and Kaempferol as Multi-Targeting Antidiabetic Agents against Mouse Model of Chemically Induced Type 2 Diabetes", "url": "https://doi.org/10.3390/ph17060757"}, {"doi": "10.3892/ijmm.2023.5321", "study": "Quercetin alleviates lipopolysaccharide‑induced acute lung injury by inhibiting ferroptosis via the Sirt1/Nrf2/Gpx4 pathway", "url": "https://doi.org/10.3892/ijmm.2023.5321"}], "claim": "directionally favorable: Quercetin alleviates lipopolysaccharide‑induced acute lung injury by inhibiting ferroptosis via the Sirt1/Nrf2/Gpx4 pathway — targeted in vivo inhibition or in vitro knockdown of Sirt1 significantly reduced the anti‑ferroptotic functions of quercetin. ( mechanistic ablation supports the topic effect; not a comparator outcome)", "claim_id": "claim_3"}, {"candidate_sources": [{"doi": "10.4236/jdm.2012.21013", "study": "Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats", "url": "https://doi.org/10.4236/jdm.2012.21013"}, {"doi": "10.3390/nu8010027", "study": "Quercetin Attenuates Chronic Ethanol-Induced Hepatic Mitochondrial Damage through Enhanced Mitophagy", "url": "https://doi.org/10.3390/nu8010027"}, {"doi": "10.3390/metabo13010130", "study": "Quercetin, a Plant Flavonol Attenuates Diabetic Complications, Renal Tissue Damage, Renal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Rats", "url": "https://doi.org/10.3390/metabo13010130"}, {"doi": "10.3390/ph17060757", "study": "Quercetin and Kaempferol as Multi-Targeting Antidiabetic Agents against Mouse Model of Chemically Induced Type 2 Diabetes", "url": "https://doi.org/10.3390/ph17060757"}, {"doi": "10.3892/ijmm.2023.5321", "study": "Quercetin alleviates lipopolysaccharide‑induced acute lung injury by inhibiting ferroptosis via the Sirt1/Nrf2/Gpx4 pathway", "url": "https://doi.org/10.3892/ijmm.2023.5321"}], "claim": "Specific moderators in this bundle are population/indication (STZ-induced diabetic rats; mice; mouse and cell models; streptozotocin-induced diabetic rats; streptozotocin-nicotinamide (STZ-NA)-induced diabetic mice), study design/evidence type (primary).", "claim_id": "claim_4"}, {"candidate_sources": [{"doi": "10.4236/jdm.2012.21013", "study": "Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats", "url": "https://doi.org/10.4236/jdm.2012.21013"}, {"doi": "10.3390/nu8010027", "study": "Quercetin Attenuates Chronic Ethanol-Induced Hepatic Mitochondrial Damage through Enhanced Mitophagy", "url": "https://doi.org/10.3390/nu8010027"}, {"doi": "10.3390/metabo13010130", "study": "Quercetin, a Plant Flavonol Attenuates Diabetic Complications, Renal Tissue Damage, Renal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Rats", "url": "https://doi.org/10.3390/metabo13010130"}, {"doi": "10.3390/ph17060757", "study": "Quercetin and Kaempferol as Multi-Targeting Antidiabetic Agents against Mouse Model of Chemically Induced Type 2 Diabetes", "url": "https://doi.org/10.3390/ph17060757"}, {"doi": "10.3892/ijmm.2023.5321", "study": "Quercetin alleviates lipopolysaccharide‑induced acute lung injury by inhibiting ferroptosis via the Sirt1/Nrf2/Gpx4 pathway", "url": "https://doi.org/10.3892/ijmm.2023.5321"}], "claim": "The selected receipts group because each carries a fact-level extraction for quercetin; they separate by context (animal model) and endpoint, so they are not interchangeable evidence for one pooled claim.", "claim_id": "claim_5"}, {"candidate_sources": [{"doi": "10.4236/jdm.2012.21013", "study": "Effect of quercetin on postprandial glucose excursion after mono- and disaccharides challenge in normal and diabetic rats", "url": "https://doi.org/10.4236/jdm.2012.21013"}, {"doi": "10.3390/nu8010027", "study": "Quercetin Attenuates Chronic Ethanol-Induced Hepatic Mitochondrial Damage through Enhanced Mitophagy", "url": "https://doi.org/10.3390/nu8010027"}, {"doi": "10.3390/metabo13010130", "study": "Quercetin, a Plant Flavonol Attenuates Diabetic Complications, Renal Tissue Damage, Renal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Rats", "url": "https://doi.org/10.3390/metabo13010130"}, {"doi": "10.3390/ph17060757", "study": "Quercetin and Kaempferol as Multi-Targeting Antidiabetic Agents against Mouse Model of Chemically Induced Type 2 Diabetes", "url": "https://doi.org/10.3390/ph17060757"}, {"doi": "10.3892/ijmm.2023.5321", "study": "Quercetin alleviates lipopolysaccharide‑induced acute lung injury by inhibiting ferroptosis via the Sirt1/Nrf2/Gpx4 pathway", "url": "https://doi.org/10.3892/ijmm.2023.5321"}], "claim": "The signal is purely descriptive of effect-direction heterogeneity; it cannot support even a weak causal or comparative-efficacy inference, and pooling across these PICOs would be inappropriate.", "claim_id": "claim_6"}]}
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