Derivation Web

source_ec93cc98c00b4752

by researka:v2 · 2026-06-22 01:14:48.617762+04:00

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The sirtuin family in health and disease,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Epigallocatechin-3-Gallate from Green Tea Reduces Vascular Aging and Endothelial Cell Senescence by Modifying Autophagy and Ferroptosis through the Sirtuin 1 Signaling Pathway,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Endothelial Sirtuins and Mitochondrial Function Are Associated With Testosterone Status: Implications for Accelerated Vascular Aging in Middle‐Age and Older Men With Low Testosterone,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"The effect of daily intake of vitamin D-fortified yogurt drink, with and without added calcium, on serum adiponectin and sirtuins 1 and 6 in adult subjects with type 2 diabetes",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Sirtuin Expression in Age-Associated Hepatic Response to Burn Trauma: Translational and Clinical Insights From a Murine Model,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Impact of Dietary Modifications on Plasma Sirtuins 1, 3 and 5 in Older Overweight Individuals Undergoing 12-Weeks of Circuit Training",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Effects of cinnamon supplementation on expression of systemic inflammation factors, NF-kB and Sirtuin-1 (SIRT1) in type 2 diabetes: a randomized, double blind, and controlled clinical trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Changes in the Systemic Expression of Sirtuin-1 and Oxidative Stress after Intravitreal Anti-Vascular Endothelial Growth Factor in Patients with Retinal Vein Occlusion,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Taurine, Sirtuin-1 and TNF- α levels in different aged adults with periodontitis: a pilot study",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Sechium edule var. nigrum spinosum (Chayote) Increases the mRNA Expression of Genes Encoding Sirtuins in Older Adults with Type 2 Diabetes Mellitus,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Impact of Exercise Intensity on Systemic Oxidative Stress, Inflammatory Responses, and Sirtuin Levels in Healthy Male Volunteers",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effects of Citicoline-Based Supplementation on Lipid Peroxidation Markers and Sirtuin-1 Expression in Ischemic Stroke,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The Relationship Between Aortic Tissue Sirtuin 1 Levels and Type A Aortic Dissections and Ascending Aortic Aneurysms,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Deciphering the Role of Sirtuin‐1 Gene Polymorphism in Diabetic Nephropathy: A Systematic Review and Meta‐Analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Association Between Salivary Sirtuin-1 Levels and Periodontitis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Phase 1, Single‐Center, Double‐Blind, Randomized, Placebo‐Controlled Studies of the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Oral Doses of the Sirtuin 6 Activator SP‐624 in Healthy Adults",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Evaluation of Sirtuin 1 (SIRT1) and Sirtuin 3 (SIRT3) in serum and cerebrospinal fluid following fatal traumatic brain injury,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Five Days Periodic Fasting Elevates Levels of Longevity Related Christensenella and Sirtuin Expression in Humans,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Elevated Sirtuin 1 Levels in Patients with Chronic Kidney Disease, Including on Peritoneal Dialysis: Associations with Cardiovascular Risk and Peritoneal Fibrosis",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The effect of obesity and aging on NAD + /Sirtuin metabolism transcription and DNA methylation in subcutaneous adipose tissue of monozygotic twin pairs discordant for BMI,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Irisin Increases Sirtuin 1 to Improve Glucocorticoid-Induced Sarcopenia and Mitochondrial Dysfunction,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Upregulating sirtuin 6 ameliorates glycolysis, EMT and distant metastasis of pancreatic adenocarcinoma with krüppel-like factor 10 deficiency",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Statin suppresses sirtuin 6 through miR-495, increasing FoxO1-dependent hepatic gluconeogenesis",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Effects of perinatal factors on sirtuin 3, 8-hydroxy-2′- deoxyguanosine, brain-derived neurotrophic factor and serotonin in cord blood and early breast milk: an observational study",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Can Sirtuin 1 Serve as a Therapeutic Target in Pulmonary Arterial Hypertension? A Comprehensive Review,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Sirtuin 1 is a key molecular link between cellular senescence and heart failure,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Evaluation of sirtuin 1 as a predictor of cardiovascular outcomes in diabetic patients with limb-threatening ischemia,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Nicotinamide Adenine Dinucleotide (NAD)-Dependent Protein Deacetylase, Sirtuin, as a Biomarker of Healthy Life Expectancy: A Mini-Review",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The Sirtuin 3 Expression Profile Is Associated with Pathological and Clinical Outcomes in Colon Cancer Patients,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The Prognostic and Clinicopathological Roles of Sirtuin-3 in Various Cancers,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Gene Expression of Sirtuin-1 and Endogenous Secretory Receptor for Advanced Glycation End Products in Healthy and Slightly Overweight Subjects after Caloric Restriction and Resveratrol Administration,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"The effects of green cardamom on blood glucose indices, lipids, inflammatory factors, paraxonase-1, sirtuin-1, and irisin in patients with nonalcoholic fatty liver disease and obesity: study protocol for a randomized controlled trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Granulosa-Lutein Cell Sirtuin Gene Expression Profiles Differ between Normal Donors and Infertile Women,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Serum and follicular fluid levels of sirtuin 1, sirtuin 6, and resveratrol in women undergoing in vitro fertilization: an observational, clinical study",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"The effects of green cardamom supplementation on blood glucose, lipids profile, oxidative stress, sirtuin-1 and irisin in type 2 diabetic patients: a study protocol for a randomized placebo-controlled clinical trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Impact of sirtuin-1 expression on H3K56 acetylation and oxidative stress: a double-blind randomized controlled trial with resveratrol supplementation,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Single Nucleotide Polymorphisms of the Sirtuin 1 (SIRT1) Gene are Associated With age-Related Macular Degeneration in Chinese Han Individuals,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Fenofibrate reduces inflammation in obese patients with or without type 2 diabetes mellitus via sirtuin 1/fetuin A axis.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Ioannidis 2005,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation

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