source · application/json
source_ed4dce26d5d641f5
sha256 0c36a3d82d3d6456bf41da980f537a02da2c4b0fe3506813d6133d13349cca3a
by researka:v2 · 2026-06-24 05:56:25.918943+04:00
{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "e7c852f1-873a-4cb5-98d6-2f49fad6de83", "sources": [{"directness": "primary", "doi": "10.1186/s40246-025-00753-6", "risk_of_bias": "not appraised in public sidecar", "study": "Pharmacogenomic insights into atorvastatin and rosuvastatin adverse effects: a prospective observational study in the UAE’s multiethnic population"}, {"directness": "review-level", "doi": "10.1186/s12876-025-04398-6", "risk_of_bias": "not appraised in public sidecar", "study": "The impact of statin use on colorectal cancer prognosis: a systematic review and meta-analysis"}, {"directness": "primary", "doi": "10.1177/13872877261424220", "risk_of_bias": "not appraised in public sidecar", "study": "Alzheimer's disease in patients prescribed statins: A real-world data analysis of U.S. patient health records"}, {"directness": "primary", "doi": "10.1007/s11357-025-01682-x", "risk_of_bias": "not appraised in public sidecar", "study": "The association between statins and gait speed reserve in older adults: effects of concomitant medication"}, {"directness": "primary", "doi": "10.1002/bcp.70493", "risk_of_bias": "not appraised in public sidecar", "study": "APOE genotype and the effect of statins on lipid outcomes: A meta‐analysis"}, {"directness": "review-level", "doi": "10.1371/journal.pone.0323749", "risk_of_bias": "not appraised in public sidecar", "study": "Impact of statins as immune-modulatory agents on inflammatory markers in adults with chronic diseases: A systematic review and meta-analysis"}, {"directness": "review-level", "doi": "10.1155/cdr/6684099", "risk_of_bias": "not appraised in public sidecar", "study": "A Meta-Analysis of the Incidence of Adverse Reactions of Statins in Various Diseases"}, {"directness": "review-level", "doi": "10.1007/s00423-026-04011-8", "risk_of_bias": "not appraised in public sidecar", "study": "Pre-morbid statin use and mortality in trauma: a systematic review and meta-analysis"}, {"directness": "review-level", "doi": "10.1002/clc.70204", "risk_of_bias": "not appraised in public sidecar", "study": "Comparative Effectiveness of Cholesteryl Ester Transfer Protein (CETP) Inhibitors on Lipid Profiles in Adults With Hyperlipidemia: A Comprehensive Systematic Review and Frequentist Network Meta‐Analysis of Randomized Controlled Trials"}, {"directness": "review-level", "doi": "10.1186/s10194-025-01957-w", "risk_of_bias": "not appraised in public sidecar", "study": "Exploring the association between statins use or HMG-CoA reductase inhibition and migraine: a systematic review and meta-analysis"}, {"directness": "primary", "doi": "10.1016/j.eclinm.2026.103798", "risk_of_bias": "not appraised in public sidecar", "study": "Reno-protective effects of statins among patients with chronic kidney disease in Hong Kong: a target trial emulation"}, {"directness": "review-level", "doi": "10.1186/s13643-026-03186-x", "risk_of_bias": "not appraised in public sidecar", "study": "Pemafibrate for hypertriglyceridemia: a meta-analysis of randomized controlled trials evaluating efficacy and safety outcomes"}, {"directness": "review-level", "doi": "10.3389/fmed.2025.1640270", "risk_of_bias": "not appraised in public sidecar", "study": "Comparative effectiveness of statins for chronic obstructive pulmonary disease patients with pulmonary hypertension: systematic review and network meta-analysis"}, {"directness": "primary", "doi": "10.1007/s12325-025-03429-8", "risk_of_bias": "not appraised in public sidecar", "study": "LDL-C Goal Attainment with Fixed-Dose Ezetimibe and Atorvastatin Versus High-Dose Atorvastatin in Chinese Patients: Subgroup Analysis of a Randomized Trial"}, {"directness": "review-level", "doi": "10.3389/fcvm.2025.1612095", "risk_of_bias": "not appraised in public sidecar", "study": "Effectiveness of combining PCSK9 inhibitors with statins on major adverse cardiovascular events and lipid levels in patients after percutaneous coronary intervention: a systematic review and meta-analysis"}, {"directness": "primary", "doi": "10.3349/ymj.2024.0476", "risk_of_bias": "not appraised in public sidecar", "study": "Prognostic Implication of LDL-C Variability and Its Association with Lipid-Lowering Strategies: Insights from the RACING and LODESTAR Trials"}, {"directness": "review-level", "doi": "10.3390/medicina61091563", "risk_of_bias": "not appraised in public sidecar", "study": "The Impact of Statin Use on Sepsis Mortality: A Systematic Review and Meta-Analysis"}, {"directness": "review-level", "doi": "10.1002/cre2.70364", "risk_of_bias": "not appraised in public sidecar", "study": "Adjunctive Use of Locally Delivered Statins in Periodontal Therapy and Pre‐Implant Bone Regeneration: A Systematic Review and Meta‐Analysis"}, {"directness": "primary", "doi": "10.1002/clc.70170", "risk_of_bias": "not appraised in public sidecar", "study": "Effect of Statin Intensity on Cardiovascular Outcomes and Survival Following Coronary Artery Bypass Grafting"}, {"directness": "review-level", "doi": "10.5144/0256-4947.2025.112", "risk_of_bias": "not appraised in public sidecar", "study": "High-dose statins for the prevention of recurrent ischemic stroke: a systematic review and meta-analysis of randomized controlled trials"}, {"directness": "review-level", "doi": "10.1186/s12884-025-07967-5", "risk_of_bias": "not appraised in public sidecar", "study": "The role of statins during pregnancy on maternal risk of preeclampsia: a systematic review and meta-analysis"}, {"directness": "primary", "doi": "10.1097/MD.0000000000044984", "risk_of_bias": "not appraised in public sidecar", "study": "Exploring the relationship between atorvastatin and rosuvastatin use and respiratory, thoracic, and mediastinal disorders: A retrospective study"}, {"directness": "review-level", "doi": "10.1590/S0004-2803.24612025-036", "risk_of_bias": "not appraised in public sidecar", "study": "ROLE OF STATINS IN CIRRHOTIC PORTAL HYPERTENSION: META-ANALYSIS OF RANDOMIZED STUDIES"}, {"directness": "primary", "doi": "10.1186/s13063-025-08943-2", "risk_of_bias": "not appraised in public sidecar", "study": "Efficacy, safety and cost-effectiveness of 40 mg versus 80 mg atorvastatin in a Sri Lankan cohort with acute coronary syndrome: a protocol for a single-centre randomised controlled clinical trial"}, {"directness": "primary", "doi": "10.1111/ene.70504", "risk_of_bias": "not appraised in public sidecar", "study": "Myasthenia Gravis Outcomes After Use of Statins and Other Contraindicated Treatments: Results From the French National Insurance Database"}, {"directness": "primary", "doi": "10.1590/2175-8239-JBN-2025-0212en", "risk_of_bias": "not appraised in public sidecar", "study": "Effect of lifestyle modification and atorvastatin on dyslipidemia and endothelial dysfunction markers in children with steroid resistant nephrotic syndrome"}, {"directness": "primary", "doi": "10.1161/CIRCGEN.125.005345", "risk_of_bias": "not appraised in public sidecar", "study": "Integrative Proteomic and Lipidomic Analysis of Patients With Acute Myocardial Infarction Treated With PCSK9 Antibodies and Statins"}, {"directness": "primary", "doi": "10.1097/MD.0000000000043940", "risk_of_bias": "not appraised in public sidecar", "study": "The role of statins in modulating subclinical inflammatory markers in coronary slow flow phenomenon"}, {"directness": "primary", "doi": "10.1136/bmjopen-2024-093833", "risk_of_bias": "not appraised in public sidecar", "study": "Rationale and design of ‘discontinuing statins in multimorbid older adults without cardiovascular disease (STREAM)’: study protocol of a randomised non-inferiority clinical trial"}, {"directness": "primary", "doi": "10.1161/JAHA.125.046943", "risk_of_bias": "not appraised in public sidecar", "study": "Recurrent Symptomatic Hemorrhage in Cerebral Cavernous Malformations After Discontinuation of Atorvastatin or Placebo"}, {"directness": "primary", "doi": "10.1161/JAHA.125.042112", "risk_of_bias": "not appraised in public sidecar", "study": "Rationale and Design of the EPISODE Trial: A Randomized Controlled Trial on the Effect of PCSK9 Inhibitors in Calcific Aortic Valve Stenosis"}, {"directness": "review-level", "doi": "10.3389/fphar.2025.1473796", "risk_of_bias": "not appraised in public sidecar", "study": "The role of statins in dementia or Alzheimer’s disease incidence: a systematic review and meta-analysis of cohort studies"}, {"directness": "review-level", "doi": "10.3389/fendo.2026.1694928", "risk_of_bias": "not appraised in public sidecar", "study": "Clinical efficacy of combining fenofibrate with statins in patients with diabetes and hyperlipidemia: a meta-analysis"}, {"directness": "review-level", "doi": "10.1186/s40001-025-02805-y", "risk_of_bias": "not appraised in public sidecar", "study": "Efficacy and safety of statins, ezetimibe, and fibrates monotherapy or combination therapy for hyperlipidemia: a systematic review and network meta-analysis"}, {"directness": "review-level", "doi": "10.1080/07853890.2025.2594355", "risk_of_bias": "not appraised in public sidecar", "study": "Ezetimibe and the risk of new-onset type 2 diabetes: a systematic review and meta-analysis"}, {"directness": "review-level", "doi": "10.3389/fonc.2026.1763323", "risk_of_bias": "not appraised in public sidecar", "study": "Prognostic role of statins in colorectal cancer: a systematic review and meta-analysis"}, {"directness": "primary", "doi": "10.1186/s13063-025-09097-x", "risk_of_bias": "not appraised in public sidecar", "study": "Effect of atorvastatin versus no S tatin T reatment on major clinical events in A cute C ardio E mbolic stroke patients without a definite indication for statin therapy: protocol for the STACE trial"}, {"directness": "primary", "doi": "10.22336/rjo.2025.35", "risk_of_bias": "not appraised in public sidecar", "study": "Assessing the Role of Statins as an Adjunctive Anti-VEGF Therapy for Clinically Significant Macular Edema (CSME) in Type 2 Diabetes Mellitus"}, {"directness": "review-level", "doi": "10.1136/bmjopen-2024-091971", "risk_of_bias": "not appraised in public sidecar", "study": "Effect of statins on neurological functional outcomes in critically ill adult patients with traumatic brain injury: a systematic review and meta-analysis"}, {"directness": "review-level", "doi": "10.3389/fendo.2025.1512670", "risk_of_bias": "not appraised in public sidecar", "study": "Lipid-lowering effect of combined therapy with high-intensity statins and CETP inhibitors: a Systematic Review and meta-analysis"}, {"directness": "primary", "doi": "10.1111/cts.70318", "risk_of_bias": "not appraised in public sidecar", "study": "Effectiveness of Statins for Oxaliplatin‐Induced Peripheral Neuropathy: A Multicenter Retrospective Observational Study"}, {"directness": "review-level", "doi": "10.3389/fphar.2026.1815366", "risk_of_bias": "not appraised in public sidecar", "study": "The antitumoral effect of statins in pancreatic ductal adenocarcinoma: a scoping review"}, {"directness": "primary", "doi": "10.1136/bmjopen-2026-120048", "risk_of_bias": "not appraised in public sidecar", "study": "Pragmatic trial assessing polygenic risk driven statin therapy for cardiovascular disease prevention: study protocol for the EE-PRS trial"}, {"directness": "primary", "doi": "10.1002/bcp.70440", "risk_of_bias": "not appraised in public sidecar", "study": "Trust first, concerns second: An international vignette study of older adults' preferences towards deprescribing statins"}, {"directness": "review-level", "doi": "10.2174/011573403X343512250127075044", "risk_of_bias": "not appraised in public sidecar", "study": "Slowing Thoracic Aortic Aneurysm Growth with Statins: A Meta-Analysis"}, {"directness": "primary", "doi": "10.1371/journal.pone.0332876", "risk_of_bias": "not appraised in public sidecar", "study": "Statin effect on arrhythmogenic cardiomyopathy disease progression (SEARCH): Randomized clinical study protocol"}, {"directness": "primary", "doi": "10.1002/14651858.CD014565", "risk_of_bias": "not appraised in public sidecar", "study": "HMG‐CoA reductase inhibitors (statins) versus placebo for people with schizophrenia"}, {"directness": "primary", "doi": "10.1016/j.phrs.2024.107575", "risk_of_bias": "not appraised in public sidecar", "study": "GWAS of CRP response to statins further supports the role of APOE in statin response: A GIST consortium study"}, {"directness": "review-level", "doi": "10.3389/fneur.2026.1753992", "risk_of_bias": "not appraised in public sidecar", "study": "The effect of statins on the survival of patients with amyotrophic lateral sclerosis: a meta-analysis"}, {"directness": "review-level", "doi": "10.1038/s41598-025-22302-w", "risk_of_bias": "not appraised in public sidecar", "study": "Preclinical efficacy and mechanisms of statin-loaded polymeric nanocapsules: a meta-analysis of tumor lipid metabolism inhibition"}, {"directness": "review-level", "doi": "10.1016/j.jare.2024.12.020", "risk_of_bias": "not appraised in public sidecar", "study": "Advances in statin adverse reactions and the potential mechanisms: A systematic review"}, {"directness": "review-level", "doi": "10.2174/0115701611419387251202152013", "risk_of_bias": "not appraised in public sidecar", "study": "The Potential Role of Statins in Infective Endocarditis: A Meta-Analysis."}, {"directness": "review-level", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "STREAM Trial - Biomarker"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "STREAM Trial Biomarker 2026"}, {"directness": "citation", "doi": "10.1001/jama.2010.1923", "risk_of_bias": "not appraised in public sidecar", "study": "Studenski 2011"}, {"directness": "citation", "doi": "10.1093/ageing/26.1.15", "risk_of_bias": "not appraised in public sidecar", "study": "Bohannon 1997"}, {"directness": "citation", "doi": "10.1371/journal.pmed.0020124", "risk_of_bias": "not appraised in public sidecar", "study": "Ioannidis 2005"}]}
metadata
{
"researka_object_type": "publication_sidecar",
"researka_publication_id": "e7c852f1-873a-4cb5-98d6-2f49fad6de83",
"researka_submission_id": "30b8af18-f881-419d-86bc-5f8a1f4425b1",
"sidecar_name": "risk_of_bias.json",
"sidecar_url": "https://api.researka.org/publications/e7c852f1-873a-4cb5-98d6-2f49fad6de83/sidecars/risk_of_bias.json"
}