Derivation Web

source_edbfd3f4f9a4438f

by researka:v2 · 2026-06-26 10:16:07.271394+04:00

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "4a4ef105-6735-457c-a03e-c95da4a8e083", "sources": [{"directness": "primary", "doi": "10.1186/s13287-023-03359-8", "risk_of_bias": "not appraised in public sidecar", "study": "Cartilage regeneration and inflammation modulation in knee osteoarthritis following injection of allogeneic adipose-derived mesenchymal stromal cells: a phase II, triple-blinded, placebo controlled, randomized trial"}, {"directness": "primary", "doi": "10.1016/j.ebiom.2026.106268", "risk_of_bias": "not appraised in public sidecar", "study": "Safety and efficacy of allogeneic umbilical cord-derived mesenchymal stem cell infusion for frailty: a phase 2, single-centre, randomised, open-label controlled trial"}, {"directness": "primary", "doi": "10.1186/s13287-024-03746-9", "risk_of_bias": "not appraised in public sidecar", "study": "A phase I/II clinical trial of ex-vivo expanded human bone marrow derived allogeneic mesenchymal stromal cells in adult patients with perianal fistulizing Crohn’s Disease"}, {"directness": "primary", "doi": "10.1186/s13287-025-04577-y", "risk_of_bias": "not appraised in public sidecar", "study": "Allogeneic bone marrow-derived mesenchymal stem cells in the aging kidney: secondary results of a Parkinson’s disease clinical trial"}, {"directness": "review-level", "doi": "10.1007/s12015-024-10696-5", "risk_of_bias": "not appraised in public sidecar", "study": "Bone Regeneration with Mesenchymal Stem Cells in Scaffolds: Systematic Review of Human Clinical Trials"}, {"directness": "primary", "doi": "10.1186/s13287-025-04356-9", "risk_of_bias": "not appraised in public sidecar", "study": "Treatment of osteoarthritic knee with high tibial osteotomy and allogeneic human umbilical cord blood–derived mesenchymal stem cells combined with hyaluronate hydrogel composite"}, {"directness": "primary", "doi": "10.1371/journal.pone.0342452", "risk_of_bias": "not appraised in public sidecar", "study": "Stem cell therapy for female stress urinary incontinence: Results, limitations and lessons learned from a pilot clinical study"}, {"directness": "primary", "doi": "10.3389/fimmu.2026.1789537", "risk_of_bias": "not appraised in public sidecar", "study": "MesenSistem-EB: systemic haploidentical mesenchymal stem cell therapy in recessive dystrophic epidermolysis bullosa associated with clinical benefits and correlated with MCP1 and sCD40L dynamics"}, {"directness": "primary", "doi": "10.4252/wjsc.v17.i5.101675", "risk_of_bias": "not appraised in public sidecar", "study": "Multiroute administration of Wharton’s jelly mesenchymal stem cells in chronic complete spinal cord injury: A phase I safety and feasibility study"}, {"directness": "primary", "doi": "10.1186/s13287-023-03390-9", "risk_of_bias": "not appraised in public sidecar", "study": "Report of a phase 1 clinical trial for safety assessment of human placental mesenchymal stem cells therapy in patients with critical limb ischemia (CLI)"}, {"directness": "primary", "doi": "10.1177/1098612X251385852", "risk_of_bias": "not appraised in public sidecar", "study": "Clinical field study evaluating the safety and efficacy of allogeneic uterine-derived mesenchymal stem cells for refractory feline chronic gingivostomatitis"}, {"directness": "primary", "doi": "10.1186/s13287-023-03545-8", "risk_of_bias": "not appraised in public sidecar", "study": "Autologous mesenchymal stromal cells embedded with Tissucol Duo ® for prevention of air leak after anatomical lung resection: results of a prospective phase I/II clinical trial with long-term follow-up"}, {"directness": "review-level", "doi": "10.3389/fphar.2024.1511525", "risk_of_bias": "not appraised in public sidecar", "study": "Protective effects and possible mechanisms of mesenchymal stem cells and mesenchymal stem cell-derived extracellular vesicles against kidney fibrosis in animal models: a systematic review and meta-analysis"}, {"directness": "primary", "doi": "10.1186/s13287-023-03531-0", "risk_of_bias": "not appraised in public sidecar", "study": "Efficacy and safety of allogeneic umbilical cord-derived mesenchymal stem cells for the treatment of complex perianal fistula in Crohn’s disease: a pilot study"}, {"directness": "review-level", "doi": "10.1177/09636897261457229", "risk_of_bias": "not appraised in public sidecar", "study": "Optimizing dose and delivery route in mesenchymal stromal cells (MSCs)-based therapy: A systematic review of their implications for clinical efficacy"}, {"directness": "primary", "doi": "10.1002/sctm.21-0021", "risk_of_bias": "not appraised in public sidecar", "study": "Advances in mesenchymal stem cell therapy for immune and inflammatory diseases: Use of cell‐free products and human pluripotent stem cell‐derived mesenchymal stem cells"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen."}, {"directness": "citation", "doi": "10.1371/journal.pmed.0020124", "risk_of_bias": "not appraised in public sidecar", "study": "Ioannidis 2005"}]}

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}