source · application/json
source_eee891d714ae4faf
sha256 8997f051384662aea38e8c3919be4dcd6784d7478735c900861d3d1d110c74e2
by researka:v2 · 2026-07-04 10:16:45.843729+04:00
{"publication_id": "145fcccc-2360-4120-8674-34dd3e97ade7", "traces": [{"candidate_sources": [{"directness": "review-level", "doi": "10.1186/s12885-020-07117-4", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12885-020-07117-4"}, {"directness": "primary", "doi": "10.5152/AnatolJCardiol.2021.541", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "An Evaluation of Aspirin Treatment Preferences of Physicians in Hypertensive Patients in Terms of Current Guidelines: A Subgroup Analysis of the ASSOS Trial in Turkey", "support_kind": "candidate_source_row", "url": "https://doi.org/10.5152/AnatolJCardiol.2021.541"}, {"directness": "primary", "doi": "10.3389/fonc.2021.633462", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Can Aspirin Use Be Associated With the Risk or Prognosis of Bladder Cancer? A Case-Control Study and Meta-analytic Assessment", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3389/fonc.2021.633462"}, {"directness": "primary", "doi": "10.1001/jamanetworkopen.2022.3890", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Association of Early Aspirin Use With In-Hospital Mortality in Patients With Moderate COVID-19", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1001/jamanetworkopen.2022.3890"}, {"directness": "primary", "doi": "10.1038/s41523-025-00775-2", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Regular aspirin use, breast tumor characteristics and long-term breast cancer survival", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41523-025-00775-2"}], "claim": "Evidence-honesty note: The retained evidence has no direct interventional hard-endpoint evidence; indirect, review-level, adjacent, or mechanistic sources are used only to bound interpretation. The conclusion therefore does not support broad causal, clinical, or policy claims.", "claim_id": "claim_1"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1186/s12885-020-07117-4", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12885-020-07117-4"}, {"directness": "primary", "doi": "10.5152/AnatolJCardiol.2021.541", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "An Evaluation of Aspirin Treatment Preferences of Physicians in Hypertensive Patients in Terms of Current Guidelines: A Subgroup Analysis of the ASSOS Trial in Turkey", "support_kind": "candidate_source_row", "url": "https://doi.org/10.5152/AnatolJCardiol.2021.541"}, {"directness": "primary", "doi": "10.3389/fonc.2021.633462", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Can Aspirin Use Be Associated With the Risk or Prognosis of Bladder Cancer? A Case-Control Study and Meta-analytic Assessment", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3389/fonc.2021.633462"}, {"directness": "primary", "doi": "10.1001/jamanetworkopen.2022.3890", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Association of Early Aspirin Use With In-Hospital Mortality in Patients With Moderate COVID-19", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1001/jamanetworkopen.2022.3890"}, {"directness": "primary", "doi": "10.1038/s41523-025-00775-2", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Regular aspirin use, breast tumor characteristics and long-term breast cancer survival", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41523-025-00775-2"}], "claim": "We conducted an AI-assisted structured evidence synthesis across 55 curated reference papers indexed for Aspirin, extracting effect estimates, confidence intervals, and p-values into an audit-trailed evidence table while preserving the design and directness annotations supplied by the original sources.", "claim_id": "claim_2"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1186/s12885-020-07117-4", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12885-020-07117-4"}, {"directness": "primary", "doi": "10.5152/AnatolJCardiol.2021.541", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "An Evaluation of Aspirin Treatment Preferences of Physicians in Hypertensive Patients in Terms of Current Guidelines: A Subgroup Analysis of the ASSOS Trial in Turkey", "support_kind": "candidate_source_row", "url": "https://doi.org/10.5152/AnatolJCardiol.2021.541"}, {"directness": "primary", "doi": "10.3389/fonc.2021.633462", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Can Aspirin Use Be Associated With the Risk or Prognosis of Bladder Cancer? A Case-Control Study and Meta-analytic Assessment", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3389/fonc.2021.633462"}, {"directness": "primary", "doi": "10.1001/jamanetworkopen.2022.3890", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Association of Early Aspirin Use With In-Hospital Mortality in Patients With Moderate COVID-19", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1001/jamanetworkopen.2022.3890"}, {"directness": "primary", "doi": "10.1038/s41523-025-00775-2", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Regular aspirin use, breast tumor characteristics and long-term breast cancer survival", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41523-025-00775-2"}], "claim": "Safety signals include increased intracerebral hemorrhage when aspirin was combined with severe hypertension (P = 0.003), whereas aspirin exposure was associated with lower severe AKI incidence in MIMIC-IV/eICU sepsis cohorts (P < 0.001), illustrating outcome- and population-dependent benefit–risk tradeoffs.", "claim_id": "claim_3"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1186/s12885-020-07117-4", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12885-020-07117-4"}, {"directness": "primary", "doi": "10.5152/AnatolJCardiol.2021.541", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "An Evaluation of Aspirin Treatment Preferences of Physicians in Hypertensive Patients in Terms of Current Guidelines: A Subgroup Analysis of the ASSOS Trial in Turkey", "support_kind": "candidate_source_row", "url": "https://doi.org/10.5152/AnatolJCardiol.2021.541"}, {"directness": "primary", "doi": "10.3389/fonc.2021.633462", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Can Aspirin Use Be Associated With the Risk or Prognosis of Bladder Cancer? A Case-Control Study and Meta-analytic Assessment", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3389/fonc.2021.633462"}, {"directness": "primary", "doi": "10.1001/jamanetworkopen.2022.3890", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Association of Early Aspirin Use With In-Hospital Mortality in Patients With Moderate COVID-19", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1001/jamanetworkopen.2022.3890"}, {"directness": "primary", "doi": "10.1038/s41523-025-00775-2", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Regular aspirin use, breast tumor characteristics and long-term breast cancer survival", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41523-025-00775-2"}], "claim": "Across outcome classes, cross-study disagreements emerged in the synthesis — most prominently null-versus-positive conflicts on contextual outcomes (Sun 2019 vs Alabsi 2023; Wang 2021a vs Huff 2025) and on longevity outcomes in specific subgroups (Wu 2024, Xu 2026, Chow 2022 vs Celik 2018) — confirming that aspirin's effect profile is context-dependent rather than uniformly beneficial.", "claim_id": "claim_4"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1186/s12885-020-07117-4", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12885-020-07117-4"}, {"directness": "primary", "doi": "10.5152/AnatolJCardiol.2021.541", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "An Evaluation of Aspirin Treatment Preferences of Physicians in Hypertensive Patients in Terms of Current Guidelines: A Subgroup Analysis of the ASSOS Trial in Turkey", "support_kind": "candidate_source_row", "url": "https://doi.org/10.5152/AnatolJCardiol.2021.541"}, {"directness": "primary", "doi": "10.3389/fonc.2021.633462", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Can Aspirin Use Be Associated With the Risk or Prognosis of Bladder Cancer? A Case-Control Study and Meta-analytic Assessment", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3389/fonc.2021.633462"}, {"directness": "primary", "doi": "10.1001/jamanetworkopen.2022.3890", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Association of Early Aspirin Use With In-Hospital Mortality in Patients With Moderate COVID-19", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1001/jamanetworkopen.2022.3890"}, {"directness": "primary", "doi": "10.1038/s41523-025-00775-2", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Regular aspirin use, breast tumor characteristics and long-term breast cancer survival", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41523-025-00775-2"}], "claim": "Interpretation below therefore separates primary clinical-trial evidence from review-level, preclinical, and other indirect evidence.", "claim_id": "claim_5"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1186/s12885-020-07117-4", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12885-020-07117-4"}, {"directness": "primary", "doi": "10.5152/AnatolJCardiol.2021.541", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "An Evaluation of Aspirin Treatment Preferences of Physicians in Hypertensive Patients in Terms of Current Guidelines: A Subgroup Analysis of the ASSOS Trial in Turkey", "support_kind": "candidate_source_row", "url": "https://doi.org/10.5152/AnatolJCardiol.2021.541"}, {"directness": "primary", "doi": "10.3389/fonc.2021.633462", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Can Aspirin Use Be Associated With the Risk or Prognosis of Bladder Cancer? A Case-Control Study and Meta-analytic Assessment", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3389/fonc.2021.633462"}, {"directness": "primary", "doi": "10.1001/jamanetworkopen.2022.3890", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Association of Early Aspirin Use With In-Hospital Mortality in Patients With Moderate COVID-19", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1001/jamanetworkopen.2022.3890"}, {"directness": "primary", "doi": "10.1038/s41523-025-00775-2", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Regular aspirin use, breast tumor characteristics and long-term breast cancer survival", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41523-025-00775-2"}], "claim": "This synthesis evaluates evidence on aspirin use effects across 55 included source papers and 2311 high-confidence extracted claims. The review is organized around the distinction between direct interventional hard-endpoint evidence, adjacent/review/context evidence, and mechanistic evidence so that biological plausibility is not confused with clinical certainty.", "claim_id": "claim_6"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1186/s12885-020-07117-4", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12885-020-07117-4"}, {"directness": "primary", "doi": "10.5152/AnatolJCardiol.2021.541", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "An Evaluation of Aspirin Treatment Preferences of Physicians in Hypertensive Patients in Terms of Current Guidelines: A Subgroup Analysis of the ASSOS Trial in Turkey", "support_kind": "candidate_source_row", "url": "https://doi.org/10.5152/AnatolJCardiol.2021.541"}, {"directness": "primary", "doi": "10.3389/fonc.2021.633462", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Can Aspirin Use Be Associated With the Risk or Prognosis of Bladder Cancer? A Case-Control Study and Meta-analytic Assessment", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3389/fonc.2021.633462"}, {"directness": "primary", "doi": "10.1001/jamanetworkopen.2022.3890", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Association of Early Aspirin Use With In-Hospital Mortality in Patients With Moderate COVID-19", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1001/jamanetworkopen.2022.3890"}, {"directness": "primary", "doi": "10.1038/s41523-025-00775-2", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Regular aspirin use, breast tumor characteristics and long-term breast cancer survival", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41523-025-00775-2"}], "claim": "The corpus contains no sources classified primarily as direct interventional hard-endpoint evidence, 55 adjacent, review, or context sources, and no sources classified primarily as mechanistic or model-system evidence. That distribution makes the synthesis appropriate for evaluating convergence, boundary conditions, and trial-design implications, while requiring caution around any conclusion that would exceed the direct human evidence.", "claim_id": "claim_7"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1186/s12885-020-07117-4", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12885-020-07117-4"}, {"directness": "primary", "doi": "10.5152/AnatolJCardiol.2021.541", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "An Evaluation of Aspirin Treatment Preferences of Physicians in Hypertensive Patients in Terms of Current Guidelines: A Subgroup Analysis of the ASSOS Trial in Turkey", "support_kind": "candidate_source_row", "url": "https://doi.org/10.5152/AnatolJCardiol.2021.541"}, {"directness": "primary", "doi": "10.3389/fonc.2021.633462", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Can Aspirin Use Be Associated With the Risk or Prognosis of Bladder Cancer? A Case-Control Study and Meta-analytic Assessment", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3389/fonc.2021.633462"}, {"directness": "primary", "doi": "10.1001/jamanetworkopen.2022.3890", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Association of Early Aspirin Use With In-Hospital Mortality in Patients With Moderate COVID-19", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1001/jamanetworkopen.2022.3890"}, {"directness": "primary", "doi": "10.1038/s41523-025-00775-2", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Regular aspirin use, breast tumor characteristics and long-term breast cancer survival", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41523-025-00775-2"}], "claim": "The introductory frame therefore treats the corpus as a set of evidence roles rather than a single directional verdict. Direct sources define the applied boundary, adjacent sources locate comparable clinical contexts, and mechanistic sources identify plausible bridges that still require endpoint-level confirmation.", "claim_id": "claim_8"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1186/s12885-020-07117-4", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12885-020-07117-4"}, {"directness": "primary", "doi": "10.5152/AnatolJCardiol.2021.541", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "An Evaluation of Aspirin Treatment Preferences of Physicians in Hypertensive Patients in Terms of Current Guidelines: A Subgroup Analysis of the ASSOS Trial in Turkey", "support_kind": "candidate_source_row", "url": "https://doi.org/10.5152/AnatolJCardiol.2021.541"}, {"directness": "primary", "doi": "10.3389/fonc.2021.633462", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Can Aspirin Use Be Associated With the Risk or Prognosis of Bladder Cancer? A Case-Control Study and Meta-analytic Assessment", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3389/fonc.2021.633462"}, {"directness": "primary", "doi": "10.1001/jamanetworkopen.2022.3890", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Association of Early Aspirin Use With In-Hospital Mortality in Patients With Moderate COVID-19", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1001/jamanetworkopen.2022.3890"}, {"directness": "primary", "doi": "10.1038/s41523-025-00775-2", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Regular aspirin use, breast tumor characteristics and long-term breast cancer survival", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41523-025-00775-2"}], "claim": "This distinction matters for publication because it makes the paper falsifiable. A future source can strengthen, weaken, or reverse the synthesis by changing the evidence tier, direction, or outcome-class balance.", "claim_id": "claim_9"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1186/s12885-020-07117-4", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12885-020-07117-4"}, {"directness": "primary", "doi": "10.5152/AnatolJCardiol.2021.541", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "An Evaluation of Aspirin Treatment Preferences of Physicians in Hypertensive Patients in Terms of Current Guidelines: A Subgroup Analysis of the ASSOS Trial in Turkey", "support_kind": "candidate_source_row", "url": "https://doi.org/10.5152/AnatolJCardiol.2021.541"}, {"directness": "primary", "doi": "10.3389/fonc.2021.633462", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Can Aspirin Use Be Associated With the Risk or Prognosis of Bladder Cancer? A Case-Control Study and Meta-analytic Assessment", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3389/fonc.2021.633462"}, {"directness": "primary", "doi": "10.1001/jamanetworkopen.2022.3890", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Association of Early Aspirin Use With In-Hospital Mortality in Patients With Moderate COVID-19", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1001/jamanetworkopen.2022.3890"}, {"directness": "primary", "doi": "10.1038/s41523-025-00775-2", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Regular aspirin use, breast tumor characteristics and long-term breast cancer survival", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41523-025-00775-2"}], "claim": "The mechanistic layer is most useful when it explains why a trial signal might appear or fail to appear. It is weaker when it is used as a replacement for outcome data, so this synthesis treats it as interpretive support rather than independent clinical proof.", "claim_id": "claim_10"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1186/s12885-020-07117-4", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12885-020-07117-4"}, {"directness": "primary", "doi": "10.5152/AnatolJCardiol.2021.541", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "An Evaluation of Aspirin Treatment Preferences of Physicians in Hypertensive Patients in Terms of Current Guidelines: A Subgroup Analysis of the ASSOS Trial in Turkey", "support_kind": "candidate_source_row", "url": "https://doi.org/10.5152/AnatolJCardiol.2021.541"}, {"directness": "primary", "doi": "10.3389/fonc.2021.633462", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Can Aspirin Use Be Associated With the Risk or Prognosis of Bladder Cancer? 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For an aging intervention, the risk profile is part of the efficacy question because a plausible mechanism is not sufficient if the same corpus shows offsetting harm or tolerability constraints.", "claim_id": "claim_12"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1186/s12885-020-07117-4", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12885-020-07117-4"}, {"directness": "primary", "doi": "10.5152/AnatolJCardiol.2021.541", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "An Evaluation of Aspirin Treatment Preferences of Physicians in Hypertensive Patients in Terms of Current Guidelines: A Subgroup Analysis of the ASSOS Trial in Turkey", "support_kind": "candidate_source_row", "url": "https://doi.org/10.5152/AnatolJCardiol.2021.541"}, {"directness": "primary", "doi": "10.3389/fonc.2021.633462", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Can Aspirin Use Be Associated With the Risk or Prognosis of Bladder Cancer? 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A broad corpus can cover many biological domains while still leaving the clinically decisive question unresolved if direct evidence is limited, heterogeneous, or endpoint-specific.", "claim_id": "claim_13"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1186/s12885-020-07117-4", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12885-020-07117-4"}, {"directness": "primary", "doi": "10.5152/AnatolJCardiol.2021.541", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "An Evaluation of Aspirin Treatment Preferences of Physicians in Hypertensive Patients in Terms of Current Guidelines: A Subgroup Analysis of the ASSOS Trial in Turkey", "support_kind": "candidate_source_row", "url": "https://doi.org/10.5152/AnatolJCardiol.2021.541"}, {"directness": "primary", "doi": "10.3389/fonc.2021.633462", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Can Aspirin Use Be Associated With the Risk or Prognosis of Bladder Cancer? 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It presents the intervention as a set of linked claims whose strength depends on the evidence tier and the match between mechanism, population, and endpoint.", "claim_id": "claim_14"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1186/s12885-020-07117-4", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12885-020-07117-4"}, {"directness": "primary", "doi": "10.5152/AnatolJCardiol.2021.541", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "An Evaluation of Aspirin Treatment Preferences of Physicians in Hypertensive Patients in Terms of Current Guidelines: A Subgroup Analysis of the ASSOS Trial in Turkey", "support_kind": "candidate_source_row", "url": "https://doi.org/10.5152/AnatolJCardiol.2021.541"}, {"directness": "primary", "doi": "10.3389/fonc.2021.633462", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Can Aspirin Use Be Associated With the Risk or Prognosis of Bladder Cancer? 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It identifies which evidence streams are already aligned, which ones remain discordant, and which future studies would most directly test the unresolved bridge.", "claim_id": "claim_15"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1186/s12885-020-07117-4", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12885-020-07117-4"}, {"directness": "primary", "doi": "10.5152/AnatolJCardiol.2021.541", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "An Evaluation of Aspirin Treatment Preferences of Physicians in Hypertensive Patients in Terms of Current Guidelines: A Subgroup Analysis of the ASSOS Trial in Turkey", "support_kind": "candidate_source_row", "url": "https://doi.org/10.5152/AnatolJCardiol.2021.541"}, {"directness": "primary", "doi": "10.3389/fonc.2021.633462", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Can Aspirin Use Be Associated With the Risk or Prognosis of Bladder Cancer? 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Direct clinical sources such as the retained evidence base are interpreted separately from mechanistic studies such as the retained evidence base, because these evidence roles answer different questions about aging biology and clinical translation.", "claim_id": "claim_16"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1186/s12885-020-07117-4", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12885-020-07117-4"}, {"directness": "primary", "doi": "10.5152/AnatolJCardiol.2021.541", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "An Evaluation of Aspirin Treatment Preferences of Physicians in Hypertensive Patients in Terms of Current Guidelines: A Subgroup Analysis of the ASSOS Trial in Turkey", "support_kind": "candidate_source_row", "url": "https://doi.org/10.5152/AnatolJCardiol.2021.541"}, {"directness": "primary", "doi": "10.3389/fonc.2021.633462", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Can Aspirin Use Be Associated With the Risk or Prognosis of Bladder Cancer? 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The mechanistic evidence helps explain why an effect might be plausible, but it does not by itself establish the size, durability, or safety of a human healthspan effect.", "claim_id": "claim_17"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1186/s12885-020-07117-4", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12885-020-07117-4"}, {"directness": "primary", "doi": "10.5152/AnatolJCardiol.2021.541", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "An Evaluation of Aspirin Treatment Preferences of Physicians in Hypertensive Patients in Terms of Current Guidelines: A Subgroup Analysis of the ASSOS Trial in Turkey", "support_kind": "candidate_source_row", "url": "https://doi.org/10.5152/AnatolJCardiol.2021.541"}, {"directness": "primary", "doi": "10.3389/fonc.2021.633462", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Can Aspirin Use Be Associated With the Risk or Prognosis of Bladder Cancer? 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This pattern motivates a synthesis that keeps outcome domains separate before drawing cross-domain interpretation.", "claim_id": "claim_18"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1186/s12885-020-07117-4", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12885-020-07117-4"}, {"directness": "primary", "doi": "10.5152/AnatolJCardiol.2021.541", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "An Evaluation of Aspirin Treatment Preferences of Physicians in Hypertensive Patients in Terms of Current Guidelines: A Subgroup Analysis of the ASSOS Trial in Turkey", "support_kind": "candidate_source_row", "url": "https://doi.org/10.5152/AnatolJCardiol.2021.541"}, {"directness": "primary", "doi": "10.3389/fonc.2021.633462", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Can Aspirin Use Be Associated With the Risk or Prognosis of Bladder Cancer? 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Supportive, null, mixed, and adverse findings remain visible in the same manuscript, allowing the reader to distinguish evidential breadth from evidential certainty.", "claim_id": "claim_19"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1186/s12885-020-07117-4", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12885-020-07117-4"}, {"directness": "primary", "doi": "10.5152/AnatolJCardiol.2021.541", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "An Evaluation of Aspirin Treatment Preferences of Physicians in Hypertensive Patients in Terms of Current Guidelines: A Subgroup Analysis of the ASSOS Trial in Turkey", "support_kind": "candidate_source_row", "url": "https://doi.org/10.5152/AnatolJCardiol.2021.541"}, {"directness": "primary", "doi": "10.3389/fonc.2021.633462", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Can Aspirin Use Be Associated With the Risk or Prognosis of Bladder Cancer? 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Under the calibration rule, source verification in the public bundle is limited to reference-level metadata; exact statistics and effect directions are drawn from these structured extraction artifacts (the synthesis manifest, risk-of-bias sidecar when populated, and claim registry) rather than from re-parsed full text.", "claim_id": "claim_21"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1186/s12885-020-07117-4", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12885-020-07117-4"}, {"directness": "primary", "doi": "10.5152/AnatolJCardiol.2021.541", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "An Evaluation of Aspirin Treatment Preferences of Physicians in Hypertensive Patients in Terms of Current Guidelines: A Subgroup Analysis of the ASSOS Trial in Turkey", "support_kind": "candidate_source_row", "url": "https://doi.org/10.5152/AnatolJCardiol.2021.541"}, {"directness": "primary", "doi": "10.3389/fonc.2021.633462", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Can Aspirin Use Be Associated With the Risk or Prognosis of Bladder Cancer? 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Public appraisal claims are limited to populated `risk_of_bias.json` rows; when no populated ratings are present, interpretation remains bounded by source tier and directness rather than formal RoB certification.", "claim_id": "claim_22"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1186/s12885-020-07117-4", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12885-020-07117-4"}, {"directness": "primary", "doi": "10.5152/AnatolJCardiol.2021.541", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "An Evaluation of Aspirin Treatment Preferences of Physicians in Hypertensive Patients in Terms of Current Guidelines: A Subgroup Analysis of the ASSOS Trial in Turkey", "support_kind": "candidate_source_row", "url": "https://doi.org/10.5152/AnatolJCardiol.2021.541"}, {"directness": "primary", "doi": "10.3389/fonc.2021.633462", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Can Aspirin Use Be Associated With the Risk or Prognosis of Bladder Cancer? A Case-Control Study and Meta-analytic Assessment", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3389/fonc.2021.633462"}, {"directness": "primary", "doi": "10.1001/jamanetworkopen.2022.3890", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Association of Early Aspirin Use With In-Hospital Mortality in Patients With Moderate COVID-19", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1001/jamanetworkopen.2022.3890"}, {"directness": "primary", "doi": "10.1038/s41523-025-00775-2", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Regular aspirin use, breast tumor characteristics and long-term breast cancer survival", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41523-025-00775-2"}], "claim": "Evidence-tension synthesis: claims grouped by outcome class (cardiometabolic, contextual adjacent evidence, deficiency prevalence, dosing and pharmacokinetics, immune and inflammation, longevity, mortality and survival, safety and comorbidity); within-class agreement, disagreement, and directness gaps surfaced explicitly. Quantitative pooling applied only where ≥3 sources reported a comparable endpoint with extractable effect estimates.", "claim_id": "claim_23"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1186/s12885-020-07117-4", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12885-020-07117-4"}, {"directness": "primary", "doi": "10.5152/AnatolJCardiol.2021.541", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "An Evaluation of Aspirin Treatment Preferences of Physicians in Hypertensive Patients in Terms of Current Guidelines: A Subgroup Analysis of the ASSOS Trial in Turkey", "support_kind": "candidate_source_row", "url": "https://doi.org/10.5152/AnatolJCardiol.2021.541"}, {"directness": "primary", "doi": "10.3389/fonc.2021.633462", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Can Aspirin Use Be Associated With the Risk or Prognosis of Bladder Cancer? A Case-Control Study and Meta-analytic Assessment", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3389/fonc.2021.633462"}, {"directness": "primary", "doi": "10.1001/jamanetworkopen.2022.3890", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Association of Early Aspirin Use With In-Hospital Mortality in Patients With Moderate COVID-19", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1001/jamanetworkopen.2022.3890"}, {"directness": "primary", "doi": "10.1038/s41523-025-00775-2", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Regular aspirin use, breast tumor characteristics and long-term breast cancer survival", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41523-025-00775-2"}], "claim": "Source retrieval, claim extraction, evidence routing, and prose drafting were assisted by large language models under a deterministic audit-trail protocol. Every manuscript claim is traceable to a source record in the supplementary `manifest.json`. Final eligibility and interpretation decisions are author-verified.", "claim_id": "claim_24"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1186/s12885-020-07117-4", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12885-020-07117-4"}, {"directness": "primary", "doi": "10.5152/AnatolJCardiol.2021.541", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "An Evaluation of Aspirin Treatment Preferences of Physicians in Hypertensive Patients in Terms of Current Guidelines: A Subgroup Analysis of the ASSOS Trial in Turkey", "support_kind": "candidate_source_row", "url": "https://doi.org/10.5152/AnatolJCardiol.2021.541"}, {"directness": "primary", "doi": "10.3389/fonc.2021.633462", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Can Aspirin Use Be Associated With the Risk or Prognosis of Bladder Cancer? A Case-Control Study and Meta-analytic Assessment", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3389/fonc.2021.633462"}, {"directness": "primary", "doi": "10.1001/jamanetworkopen.2022.3890", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Association of Early Aspirin Use With In-Hospital Mortality in Patients With Moderate COVID-19", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1001/jamanetworkopen.2022.3890"}, {"directness": "primary", "doi": "10.1038/s41523-025-00775-2", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Regular aspirin use, breast tumor characteristics and long-term breast cancer survival", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41523-025-00775-2"}], "claim": "Outcome-class note:** Contextual Adjacent Evidence denotes background, boundary-condition, or adjacent-outcome sources. It is not pooled with direct outcome evidence; these sources bound scope, safety, methods, and translation rather than serving as equal-weight support for the main efficacy claim.", "claim_id": "claim_25"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1186/s12885-020-07117-4", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12885-020-07117-4"}, {"directness": "primary", "doi": "10.5152/AnatolJCardiol.2021.541", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "An Evaluation of Aspirin Treatment Preferences of Physicians in Hypertensive Patients in Terms of Current Guidelines: A Subgroup Analysis of the ASSOS Trial in Turkey", "support_kind": "candidate_source_row", "url": "https://doi.org/10.5152/AnatolJCardiol.2021.541"}, {"directness": "primary", "doi": "10.3389/fonc.2021.633462", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Can Aspirin Use Be Associated With the Risk or Prognosis of Bladder Cancer? A Case-Control Study and Meta-analytic Assessment", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3389/fonc.2021.633462"}, {"directness": "primary", "doi": "10.1001/jamanetworkopen.2022.3890", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Association of Early Aspirin Use With In-Hospital Mortality in Patients With Moderate COVID-19", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1001/jamanetworkopen.2022.3890"}, {"directness": "primary", "doi": "10.1038/s41523-025-00775-2", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Regular aspirin use, breast tumor characteristics and long-term breast cancer survival", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41523-025-00775-2"}], "claim": "| Evidence domain | Corpus slice | Strongest signal | Directness | Main limitation |", "claim_id": "claim_26"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1186/s12885-020-07117-4", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12885-020-07117-4"}, {"directness": "primary", "doi": "10.5152/AnatolJCardiol.2021.541", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "An Evaluation of Aspirin Treatment Preferences of Physicians in Hypertensive Patients in Terms of Current Guidelines: A Subgroup Analysis of the ASSOS Trial in Turkey", "support_kind": "candidate_source_row", "url": "https://doi.org/10.5152/AnatolJCardiol.2021.541"}, {"directness": "primary", "doi": "10.3389/fonc.2021.633462", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Can Aspirin Use Be Associated With the Risk or Prognosis of Bladder Cancer? A Case-Control Study and Meta-analytic Assessment", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3389/fonc.2021.633462"}, {"directness": "primary", "doi": "10.1001/jamanetworkopen.2022.3890", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Association of Early Aspirin Use With In-Hospital Mortality in Patients With Moderate COVID-19", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1001/jamanetworkopen.2022.3890"}, {"directness": "primary", "doi": "10.1038/s41523-025-00775-2", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Regular aspirin use, breast tumor characteristics and long-term breast cancer survival", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41523-025-00775-2"}], "claim": "| Aspirin Use Effects / Contextual Adjacent Evidence | n=23; claims=984 | significant source statistic in 16/23 sources; receipt-level direction coded unclear | 14 indirect; 9 review | limited corpus depth in this outcome class |", "claim_id": "claim_27"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1186/s12885-020-07117-4", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12885-020-07117-4"}, {"directness": "primary", "doi": "10.5152/AnatolJCardiol.2021.541", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "An Evaluation of Aspirin Treatment Preferences of Physicians in Hypertensive Patients in Terms of Current Guidelines: A Subgroup Analysis of the ASSOS Trial in Turkey", "support_kind": "candidate_source_row", "url": "https://doi.org/10.5152/AnatolJCardiol.2021.541"}, {"directness": "primary", "doi": "10.3389/fonc.2021.633462", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Can Aspirin Use Be Associated With the Risk or Prognosis of Bladder Cancer? A Case-Control Study and Meta-analytic Assessment", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3389/fonc.2021.633462"}, {"directness": "primary", "doi": "10.1001/jamanetworkopen.2022.3890", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Association of Early Aspirin Use With In-Hospital Mortality in Patients With Moderate COVID-19", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1001/jamanetworkopen.2022.3890"}, {"directness": "primary", "doi": "10.1038/s41523-025-00775-2", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Regular aspirin use, breast tumor characteristics and long-term breast cancer survival", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41523-025-00775-2"}], "claim": "| Aspirin Use Effects / Cardiometabolic | n=1; claims=81 | significant source statistic in 1/1 sources; receipt-level direction coded null | 1 indirect | single-source slice; hypothesis-generating |", "claim_id": "claim_28"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1186/s12885-020-07117-4", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12885-020-07117-4"}, {"directness": "primary", "doi": "10.5152/AnatolJCardiol.2021.541", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "An Evaluation of Aspirin Treatment Preferences of Physicians in Hypertensive Patients in Terms of Current Guidelines: A Subgroup Analysis of the ASSOS Trial in Turkey", "support_kind": "candidate_source_row", "url": "https://doi.org/10.5152/AnatolJCardiol.2021.541"}, {"directness": "primary", "doi": "10.3389/fonc.2021.633462", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Can Aspirin Use Be Associated With the Risk or Prognosis of Bladder Cancer? A Case-Control Study and Meta-analytic Assessment", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3389/fonc.2021.633462"}, {"directness": "primary", "doi": "10.1001/jamanetworkopen.2022.3890", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Association of Early Aspirin Use With In-Hospital Mortality in Patients With Moderate COVID-19", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1001/jamanetworkopen.2022.3890"}, {"directness": "primary", "doi": "10.1038/s41523-025-00775-2", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Regular aspirin use, breast tumor characteristics and long-term breast cancer survival", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41523-025-00775-2"}], "claim": "Contextual Adjacent Evidence: n=23; claims=984; mixed signal in 15/23 sources | directness: 14 indirect; 9 review; main limitation: no direct clinical anchor.", "claim_id": "claim_29"}, {"candidate_sources": [{"directness": "review-level", "doi": "10.1186/s12885-020-07117-4", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Relationship between aspirin use of esophageal, gastric and colorectal cancer patient survival: a meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12885-020-07117-4"}, {"directness": "primary", "doi": "10.5152/AnatolJCardiol.2021.541", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "An Evaluation of Aspirin Treatment Preferences of Physicians in Hypertensive Patients in Terms of Current Guidelines: A Subgroup Analysis of the ASSOS Trial in Turkey", "support_kind": "candidate_source_row", "url": "https://doi.org/10.5152/AnatolJCardiol.2021.541"}, {"directness": "primary", "doi": "10.3389/fonc.2021.633462", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Can Aspirin Use Be Associated With the Risk or Prognosis of Bladder Cancer? A Case-Control Study and Meta-analytic Assessment", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3389/fonc.2021.633462"}, {"directness": "primary", "doi": "10.1001/jamanetworkopen.2022.3890", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Association of Early Aspirin Use With In-Hospital Mortality in Patients With Moderate COVID-19", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1001/jamanetworkopen.2022.3890"}, {"directness": "primary", "doi": "10.1038/s41523-025-00775-2", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Regular aspirin use, breast tumor characteristics and long-term breast cancer survival", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1038/s41523-025-00775-2"}], "claim": "The cardiometabolic evidence base for aspirin use in primary prevention is anchored by one observational cohort study, Huang 2024, which characterizes US population eligibility rather than incident events. The study identifies the proportion of US adults 40–59 years who meet USPSTF criteria for primary prevention aspirin, framing the upstream public-health denominator before any effect-size analysis is attempted. By design, this is an epidemiologic estimation paper, so the canonical endpoint is prevalence of eligibility rather than a hazard ratio for a clinical outcome. The full numeric anchor is reported in the evidence synthesis alongside any per-study effect estimate where available.", "claim_id": "claim_30"}]}
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