Derivation Web · source_ef40dd8085824148

source · application/json

source_ef40dd8085824148

sha256 a52d1bf51848f6b3bae72833ecb71f9c779cc8d84698e61d0adc5fddc4ed333c

by researka:v2 · 2026-06-06 04:10:44.758494+04:00

{"publication_id": "79d2cfdb-60fe-4786-be4f-b55cacadc266", "traces": [{"candidate_sources": [{"doi": "10.3390/cimb47080642", "study": "Harringtonine Attenuates Extracellular Matrix Degradation, Skin Barrier Dysfunction, and Inflammation in an In Vitro Skin Aging Model", "url": "https://doi.org/10.3390/cimb47080642"}, {"doi": "10.1152/function.109.2025", "study": "Repeated application of passive mechanical stress produces selective metabolic and extracellular matrix adaptations in human skeletal muscle but does not prevent disuse-induced atrophy", "url": "https://doi.org/10.1152/function.109.2025"}, {"doi": "10.3390/jcm12216866", "study": "The Role of Extracellular Matrix and Inflammation in the Stratification of Bleeding and Thrombotic Risk of Atrial Fibrillation on Oral Anticoagulant Therapy: Insights from Strat-Af Study", "url": "https://doi.org/10.3390/jcm12216866"}, {"doi": "10.1038/s41405-025-00370-4", "study": "In vitro and in vivo biocompatibility of a porcine cholecystic extracellular matrix (CECM) membrane for tissue regeneration", "url": "https://doi.org/10.1038/s41405-025-00370-4"}, {"doi": "10.1038/s42003-022-03563-x", "study": "Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes", "url": "https://doi.org/10.1038/s42003-022-03563-x"}], "claim": "The evidence profile contains no sources classified primarily as direct clinical evidence, 50 adjacent clinical sources, and 7 mechanistic or model-system sources, with 1051 cross-study disagreements across the evidence base.", "claim_id": "claim_1"}, {"candidate_sources": [{"doi": "10.3390/cimb47080642", "study": "Harringtonine Attenuates Extracellular Matrix Degradation, Skin Barrier Dysfunction, and Inflammation in an In Vitro Skin Aging Model", "url": "https://doi.org/10.3390/cimb47080642"}, {"doi": "10.1152/function.109.2025", "study": "Repeated application of passive mechanical stress produces selective metabolic and extracellular matrix adaptations in human skeletal muscle but does not prevent disuse-induced atrophy", "url": "https://doi.org/10.1152/function.109.2025"}, {"doi": "10.3390/jcm12216866", "study": "The Role of Extracellular Matrix and Inflammation in the Stratification of Bleeding and Thrombotic Risk of Atrial Fibrillation on Oral Anticoagulant Therapy: Insights from Strat-Af Study", "url": "https://doi.org/10.3390/jcm12216866"}, {"doi": "10.1038/s41405-025-00370-4", "study": "In vitro and in vivo biocompatibility of a porcine cholecystic extracellular matrix (CECM) membrane for tissue regeneration", "url": "https://doi.org/10.1038/s41405-025-00370-4"}, {"doi": "10.1038/s42003-022-03563-x", "study": "Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes", "url": "https://doi.org/10.1038/s42003-022-03563-x"}], "claim": "No single positive outcome class dominates the retained corpus; null signals cluster in the contextual adjacent evidence, immune and inflammation, immune outcome classes, and negative signals cluster in no dominant outcome class. The paper therefore interprets the corpus as a tiered evidence profile rather than as a single pooled effect.", "claim_id": "claim_2"}, {"candidate_sources": [{"doi": "10.3390/cimb47080642", "study": "Harringtonine Attenuates Extracellular Matrix Degradation, Skin Barrier Dysfunction, and Inflammation in an In Vitro Skin Aging Model", "url": "https://doi.org/10.3390/cimb47080642"}, {"doi": "10.1152/function.109.2025", "study": "Repeated application of passive mechanical stress produces selective metabolic and extracellular matrix adaptations in human skeletal muscle but does not prevent disuse-induced atrophy", "url": "https://doi.org/10.1152/function.109.2025"}, {"doi": "10.3390/jcm12216866", "study": "The Role of Extracellular Matrix and Inflammation in the Stratification of Bleeding and Thrombotic Risk of Atrial Fibrillation on Oral Anticoagulant Therapy: Insights from Strat-Af Study", "url": "https://doi.org/10.3390/jcm12216866"}, {"doi": "10.1038/s41405-025-00370-4", "study": "In vitro and in vivo biocompatibility of a porcine cholecystic extracellular matrix (CECM) membrane for tissue regeneration", "url": "https://doi.org/10.1038/s41405-025-00370-4"}, {"doi": "10.1038/s42003-022-03563-x", "study": "Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes", "url": "https://doi.org/10.1038/s42003-022-03563-x"}], "claim": "The conclusion is that extracellular matrix stiffening remains a bounded geroscience case: the retained clinical and adjacent evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.", "claim_id": "claim_3"}, {"candidate_sources": [{"doi": "10.3390/cimb47080642", "study": "Harringtonine Attenuates Extracellular Matrix Degradation, Skin Barrier Dysfunction, and Inflammation in an In Vitro Skin Aging Model", "url": "https://doi.org/10.3390/cimb47080642"}, {"doi": "10.1152/function.109.2025", "study": "Repeated application of passive mechanical stress produces selective metabolic and extracellular matrix adaptations in human skeletal muscle but does not prevent disuse-induced atrophy", "url": "https://doi.org/10.1152/function.109.2025"}, {"doi": "10.3390/jcm12216866", "study": "The Role of Extracellular Matrix and Inflammation in the Stratification of Bleeding and Thrombotic Risk of Atrial Fibrillation on Oral Anticoagulant Therapy: Insights from Strat-Af Study", "url": "https://doi.org/10.3390/jcm12216866"}, {"doi": "10.1038/s41405-025-00370-4", "study": "In vitro and in vivo biocompatibility of a porcine cholecystic extracellular matrix (CECM) membrane for tissue regeneration", "url": "https://doi.org/10.1038/s41405-025-00370-4"}, {"doi": "10.1038/s42003-022-03563-x", "study": "Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes", "url": "https://doi.org/10.1038/s42003-022-03563-x"}], "claim": "This manuscript is reported as a Thin-corpus evidence brief. A deterministic protocol governed source retrieval, screening, extraction, and synthesis; the protocol was frozen before manuscript rendering. The full audit trail is in the supplementary `methods_pack.json` and the timestamped submission directory `synthesis-extracellular_matrix_stiffening-v06-DAILY-2026-06-06T00-02-32Z`.", "claim_id": "claim_4"}, {"candidate_sources": [{"doi": "10.3390/cimb47080642", "study": "Harringtonine Attenuates Extracellular Matrix Degradation, Skin Barrier Dysfunction, and Inflammation in an In Vitro Skin Aging Model", "url": "https://doi.org/10.3390/cimb47080642"}, {"doi": "10.1152/function.109.2025", "study": "Repeated application of passive mechanical stress produces selective metabolic and extracellular matrix adaptations in human skeletal muscle but does not prevent disuse-induced atrophy", "url": "https://doi.org/10.1152/function.109.2025"}, {"doi": "10.3390/jcm12216866", "study": "The Role of Extracellular Matrix and Inflammation in the Stratification of Bleeding and Thrombotic Risk of Atrial Fibrillation on Oral Anticoagulant Therapy: Insights from Strat-Af Study", "url": "https://doi.org/10.3390/jcm12216866"}, {"doi": "10.1038/s41405-025-00370-4", "study": "In vitro and in vivo biocompatibility of a porcine cholecystic extracellular matrix (CECM) membrane for tissue regeneration", "url": "https://doi.org/10.1038/s41405-025-00370-4"}, {"doi": "10.1038/s42003-022-03563-x", "study": "Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes", "url": "https://doi.org/10.1038/s42003-022-03563-x"}], "claim": "The following fields were extracted from each included source: study design, population / cohort, intervention or exposure, comparator, outcome class, effect direction, effect size, confidence interval or credible interval, p-value, sample size, follow-up duration, risk-of-bias rating. Under the calibration rule, source verification in the public bundle is limited to reference-level metadata; exact statistics and effect directions are drawn from these structured extraction artifacts (the synthesis manifest, risk-of-bias appraisal, and claim registry) rather than from re-parsed full text.", "claim_id": "claim_5"}, {"candidate_sources": [{"doi": "10.3390/cimb47080642", "study": "Harringtonine Attenuates Extracellular Matrix Degradation, Skin Barrier Dysfunction, and Inflammation in an In Vitro Skin Aging Model", "url": "https://doi.org/10.3390/cimb47080642"}, {"doi": "10.1152/function.109.2025", "study": "Repeated application of passive mechanical stress produces selective metabolic and extracellular matrix adaptations in human skeletal muscle but does not prevent disuse-induced atrophy", "url": "https://doi.org/10.1152/function.109.2025"}, {"doi": "10.3390/jcm12216866", "study": "The Role of Extracellular Matrix and Inflammation in the Stratification of Bleeding and Thrombotic Risk of Atrial Fibrillation on Oral Anticoagulant Therapy: Insights from Strat-Af Study", "url": "https://doi.org/10.3390/jcm12216866"}, {"doi": "10.1038/s41405-025-00370-4", "study": "In vitro and in vivo biocompatibility of a porcine cholecystic extracellular matrix (CECM) membrane for tissue regeneration", "url": "https://doi.org/10.1038/s41405-025-00370-4"}, {"doi": "10.1038/s42003-022-03563-x", "study": "Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes", "url": "https://doi.org/10.1038/s42003-022-03563-x"}], "claim": "Per-source risk-of-bias was rated using design-appropriate Cochrane RoB-2 (RCTs), ROBINS-I (non-randomised studies), and AMSTAR-2 (systematic reviews / meta-analyses). Ratings recorded in `risk_of_bias.json`.", "claim_id": "claim_6"}, {"candidate_sources": [{"doi": "10.3390/cimb47080642", "study": "Harringtonine Attenuates Extracellular Matrix Degradation, Skin Barrier Dysfunction, and Inflammation in an In Vitro Skin Aging Model", "url": "https://doi.org/10.3390/cimb47080642"}, {"doi": "10.1152/function.109.2025", "study": "Repeated application of passive mechanical stress produces selective metabolic and extracellular matrix adaptations in human skeletal muscle but does not prevent disuse-induced atrophy", "url": "https://doi.org/10.1152/function.109.2025"}, {"doi": "10.3390/jcm12216866", "study": "The Role of Extracellular Matrix and Inflammation in the Stratification of Bleeding and Thrombotic Risk of Atrial Fibrillation on Oral Anticoagulant Therapy: Insights from Strat-Af Study", "url": "https://doi.org/10.3390/jcm12216866"}, {"doi": "10.1038/s41405-025-00370-4", "study": "In vitro and in vivo biocompatibility of a porcine cholecystic extracellular matrix (CECM) membrane for tissue regeneration", "url": "https://doi.org/10.1038/s41405-025-00370-4"}, {"doi": "10.1038/s42003-022-03563-x", "study": "Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes", "url": "https://doi.org/10.1038/s42003-022-03563-x"}], "claim": "Evidence-tension synthesis: claims grouped by outcome class (contextual adjacent evidence, immune, immune and inflammation, longevity, safety and comorbidity, skeletal, fracture, and bone); within-class agreement, disagreement, and directness gaps surfaced explicitly. Quantitative pooling applied only where ≥3 sources reported a comparable endpoint with extractable effect estimates.", "claim_id": "claim_7"}, {"candidate_sources": [{"doi": "10.3390/cimb47080642", "study": "Harringtonine Attenuates Extracellular Matrix Degradation, Skin Barrier Dysfunction, and Inflammation in an In Vitro Skin Aging Model", "url": "https://doi.org/10.3390/cimb47080642"}, {"doi": "10.1152/function.109.2025", "study": "Repeated application of passive mechanical stress produces selective metabolic and extracellular matrix adaptations in human skeletal muscle but does not prevent disuse-induced atrophy", "url": "https://doi.org/10.1152/function.109.2025"}, {"doi": "10.3390/jcm12216866", "study": "The Role of Extracellular Matrix and Inflammation in the Stratification of Bleeding and Thrombotic Risk of Atrial Fibrillation on Oral Anticoagulant Therapy: Insights from Strat-Af Study", "url": "https://doi.org/10.3390/jcm12216866"}, {"doi": "10.1038/s41405-025-00370-4", "study": "In vitro and in vivo biocompatibility of a porcine cholecystic extracellular matrix (CECM) membrane for tissue regeneration", "url": "https://doi.org/10.1038/s41405-025-00370-4"}, {"doi": "10.1038/s42003-022-03563-x", "study": "Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes", "url": "https://doi.org/10.1038/s42003-022-03563-x"}], "claim": "Source retrieval, claim extraction, evidence routing, and prose drafting were assisted by large language models under a deterministic audit-trail protocol. Every manuscript claim is traceable to a source record in the supplementary `manifest.json`. Final eligibility and interpretation decisions are author-verified.", "claim_id": "claim_8"}, {"candidate_sources": [{"doi": "10.3390/cimb47080642", "study": "Harringtonine Attenuates Extracellular Matrix Degradation, Skin Barrier Dysfunction, and Inflammation in an In Vitro Skin Aging Model", "url": "https://doi.org/10.3390/cimb47080642"}, {"doi": "10.1152/function.109.2025", "study": "Repeated application of passive mechanical stress produces selective metabolic and extracellular matrix adaptations in human skeletal muscle but does not prevent disuse-induced atrophy", "url": "https://doi.org/10.1152/function.109.2025"}, {"doi": "10.3390/jcm12216866", "study": "The Role of Extracellular Matrix and Inflammation in the Stratification of Bleeding and Thrombotic Risk of Atrial Fibrillation on Oral Anticoagulant Therapy: Insights from Strat-Af Study", "url": "https://doi.org/10.3390/jcm12216866"}, {"doi": "10.1038/s41405-025-00370-4", "study": "In vitro and in vivo biocompatibility of a porcine cholecystic extracellular matrix (CECM) membrane for tissue regeneration", "url": "https://doi.org/10.1038/s41405-025-00370-4"}, {"doi": "10.1038/s42003-022-03563-x", "study": "Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes", "url": "https://doi.org/10.1038/s42003-022-03563-x"}], "claim": "Outcome-class note:** Contextual Adjacent Evidence denotes background, boundary-condition, or adjacent-outcome sources. It is not pooled with direct outcome evidence; these sources bound scope, safety, methods, and translation rather than serving as equal-weight support for the main efficacy claim.", "claim_id": "claim_9"}, {"candidate_sources": [{"doi": "10.3390/cimb47080642", "study": "Harringtonine Attenuates Extracellular Matrix Degradation, Skin Barrier Dysfunction, and Inflammation in an In Vitro Skin Aging Model", "url": "https://doi.org/10.3390/cimb47080642"}, {"doi": "10.1152/function.109.2025", "study": "Repeated application of passive mechanical stress produces selective metabolic and extracellular matrix adaptations in human skeletal muscle but does not prevent disuse-induced atrophy", "url": "https://doi.org/10.1152/function.109.2025"}, {"doi": "10.3390/jcm12216866", "study": "The Role of Extracellular Matrix and Inflammation in the Stratification of Bleeding and Thrombotic Risk of Atrial Fibrillation on Oral Anticoagulant Therapy: Insights from Strat-Af Study", "url": "https://doi.org/10.3390/jcm12216866"}, {"doi": "10.1038/s41405-025-00370-4", "study": "In vitro and in vivo biocompatibility of a porcine cholecystic extracellular matrix (CECM) membrane for tissue regeneration", "url": "https://doi.org/10.1038/s41405-025-00370-4"}, {"doi": "10.1038/s42003-022-03563-x", "study": "Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes", "url": "https://doi.org/10.1038/s42003-022-03563-x"}], "claim": "| Evidence domain | Corpus slice | Strongest signal | Directness | Main limitation |", "claim_id": "claim_10"}, {"candidate_sources": [{"doi": "10.3390/cimb47080642", "study": "Harringtonine Attenuates Extracellular Matrix Degradation, Skin Barrier Dysfunction, and Inflammation in an In Vitro Skin Aging Model", "url": "https://doi.org/10.3390/cimb47080642"}, {"doi": "10.1152/function.109.2025", "study": "Repeated application of passive mechanical stress produces selective metabolic and extracellular matrix adaptations in human skeletal muscle but does not prevent disuse-induced atrophy", "url": "https://doi.org/10.1152/function.109.2025"}, {"doi": "10.3390/jcm12216866", "study": "The Role of Extracellular Matrix and Inflammation in the Stratification of Bleeding and Thrombotic Risk of Atrial Fibrillation on Oral Anticoagulant Therapy: Insights from Strat-Af Study", "url": "https://doi.org/10.3390/jcm12216866"}, {"doi": "10.1038/s41405-025-00370-4", "study": "In vitro and in vivo biocompatibility of a porcine cholecystic extracellular matrix (CECM) membrane for tissue regeneration", "url": "https://doi.org/10.1038/s41405-025-00370-4"}, {"doi": "10.1038/s42003-022-03563-x", "study": "Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes", "url": "https://doi.org/10.1038/s42003-022-03563-x"}], "claim": "| Contextual Adjacent Evidence | n=46; claims=816 | no extracted directional signal in 46/46 sources | 40 indirect; 4 mechanistic; 2 review | limited corpus depth in this outcome class |", "claim_id": "claim_11"}, {"candidate_sources": [{"doi": "10.3390/cimb47080642", "study": "Harringtonine Attenuates Extracellular Matrix Degradation, Skin Barrier Dysfunction, and Inflammation in an In Vitro Skin Aging Model", "url": "https://doi.org/10.3390/cimb47080642"}, {"doi": "10.1152/function.109.2025", "study": "Repeated application of passive mechanical stress produces selective metabolic and extracellular matrix adaptations in human skeletal muscle but does not prevent disuse-induced atrophy", "url": "https://doi.org/10.1152/function.109.2025"}, {"doi": "10.3390/jcm12216866", "study": "The Role of Extracellular Matrix and Inflammation in the Stratification of Bleeding and Thrombotic Risk of Atrial Fibrillation on Oral Anticoagulant Therapy: Insights from Strat-Af Study", "url": "https://doi.org/10.3390/jcm12216866"}, {"doi": "10.1038/s41405-025-00370-4", "study": "In vitro and in vivo biocompatibility of a porcine cholecystic extracellular matrix (CECM) membrane for tissue regeneration", "url": "https://doi.org/10.1038/s41405-025-00370-4"}, {"doi": "10.1038/s42003-022-03563-x", "study": "Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes", "url": "https://doi.org/10.1038/s42003-022-03563-x"}], "claim": "This evidence brief reports outcome packets as a map of retained evidence rather than as a full journal Results narrative or pooled effect estimate.", "claim_id": "claim_12"}, {"candidate_sources": [{"doi": "10.3390/cimb47080642", "study": "Harringtonine Attenuates Extracellular Matrix Degradation, Skin Barrier Dysfunction, and Inflammation in an In Vitro Skin Aging Model", "url": "https://doi.org/10.3390/cimb47080642"}, {"doi": "10.1152/function.109.2025", "study": "Repeated application of passive mechanical stress produces selective metabolic and extracellular matrix adaptations in human skeletal muscle but does not prevent disuse-induced atrophy", "url": "https://doi.org/10.1152/function.109.2025"}, {"doi": "10.3390/jcm12216866", "study": "The Role of Extracellular Matrix and Inflammation in the Stratification of Bleeding and Thrombotic Risk of Atrial Fibrillation on Oral Anticoagulant Therapy: Insights from Strat-Af Study", "url": "https://doi.org/10.3390/jcm12216866"}, {"doi": "10.1038/s41405-025-00370-4", "study": "In vitro and in vivo biocompatibility of a porcine cholecystic extracellular matrix (CECM) membrane for tissue regeneration", "url": "https://doi.org/10.1038/s41405-025-00370-4"}, {"doi": "10.1038/s42003-022-03563-x", "study": "Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes", "url": "https://doi.org/10.1038/s42003-022-03563-x"}], "claim": "46 included sources were assigned to this outcome class. Directional coding: null=46. Directness coding: indirect=40, mechanistic=4, review=2.", "claim_id": "claim_13"}, {"candidate_sources": [{"doi": "10.3390/cimb47080642", "study": "Harringtonine Attenuates Extracellular Matrix Degradation, Skin Barrier Dysfunction, and Inflammation in an In Vitro Skin Aging Model", "url": "https://doi.org/10.3390/cimb47080642"}, {"doi": "10.1152/function.109.2025", "study": "Repeated application of passive mechanical stress produces selective metabolic and extracellular matrix adaptations in human skeletal muscle but does not prevent disuse-induced atrophy", "url": "https://doi.org/10.1152/function.109.2025"}, {"doi": "10.3390/jcm12216866", "study": "The Role of Extracellular Matrix and Inflammation in the Stratification of Bleeding and Thrombotic Risk of Atrial Fibrillation on Oral Anticoagulant Therapy: Insights from Strat-Af Study", "url": "https://doi.org/10.3390/jcm12216866"}, {"doi": "10.1038/s41405-025-00370-4", "study": "In vitro and in vivo biocompatibility of a porcine cholecystic extracellular matrix (CECM) membrane for tissue regeneration", "url": "https://doi.org/10.1038/s41405-025-00370-4"}, {"doi": "10.1038/s42003-022-03563-x", "study": "Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes", "url": "https://doi.org/10.1038/s42003-022-03563-x"}], "claim": "5 included sources were assigned to this outcome class. Directional coding: null=5. Directness coding: indirect=5.", "claim_id": "claim_14"}, {"candidate_sources": [{"doi": "10.3390/cimb47080642", "study": "Harringtonine Attenuates Extracellular Matrix Degradation, Skin Barrier Dysfunction, and Inflammation in an In Vitro Skin Aging Model", "url": "https://doi.org/10.3390/cimb47080642"}, {"doi": "10.1152/function.109.2025", "study": "Repeated application of passive mechanical stress produces selective metabolic and extracellular matrix adaptations in human skeletal muscle but does not prevent disuse-induced atrophy", "url": "https://doi.org/10.1152/function.109.2025"}, {"doi": "10.3390/jcm12216866", "study": "The Role of Extracellular Matrix and Inflammation in the Stratification of Bleeding and Thrombotic Risk of Atrial Fibrillation on Oral Anticoagulant Therapy: Insights from Strat-Af Study", "url": "https://doi.org/10.3390/jcm12216866"}, {"doi": "10.1038/s41405-025-00370-4", "study": "In vitro and in vivo biocompatibility of a porcine cholecystic extracellular matrix (CECM) membrane for tissue regeneration", "url": "https://doi.org/10.1038/s41405-025-00370-4"}, {"doi": "10.1038/s42003-022-03563-x", "study": "Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes", "url": "https://doi.org/10.1038/s42003-022-03563-x"}], "claim": "3 included sources were assigned to this outcome class. Directional coding: null=3. Directness coding: indirect=2, mechanistic=1.", "claim_id": "claim_15"}, {"candidate_sources": [{"doi": "10.3390/cimb47080642", "study": "Harringtonine Attenuates Extracellular Matrix Degradation, Skin Barrier Dysfunction, and Inflammation in an In Vitro Skin Aging Model", "url": "https://doi.org/10.3390/cimb47080642"}, {"doi": "10.1152/function.109.2025", "study": "Repeated application of passive mechanical stress produces selective metabolic and extracellular matrix adaptations in human skeletal muscle but does not prevent disuse-induced atrophy", "url": "https://doi.org/10.1152/function.109.2025"}, {"doi": "10.3390/jcm12216866", "study": "The Role of Extracellular Matrix and Inflammation in the Stratification of Bleeding and Thrombotic Risk of Atrial Fibrillation on Oral Anticoagulant Therapy: Insights from Strat-Af Study", "url": "https://doi.org/10.3390/jcm12216866"}, {"doi": "10.1038/s41405-025-00370-4", "study": "In vitro and in vivo biocompatibility of a porcine cholecystic extracellular matrix (CECM) membrane for tissue regeneration", "url": "https://doi.org/10.1038/s41405-025-00370-4"}, {"doi": "10.1038/s42003-022-03563-x", "study": "Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes", "url": "https://doi.org/10.1038/s42003-022-03563-x"}], "claim": "3 included sources were assigned to this outcome class. Directional coding: null=3. Directness coding: indirect=2, mechanistic=1.", "claim_id": "claim_16"}, {"candidate_sources": [{"doi": "10.3390/cimb47080642", "study": "Harringtonine Attenuates Extracellular Matrix Degradation, Skin Barrier Dysfunction, and Inflammation in an In Vitro Skin Aging Model", "url": "https://doi.org/10.3390/cimb47080642"}, {"doi": "10.1152/function.109.2025", "study": "Repeated application of passive mechanical stress produces selective metabolic and extracellular matrix adaptations in human skeletal muscle but does not prevent disuse-induced atrophy", "url": "https://doi.org/10.1152/function.109.2025"}, {"doi": "10.3390/jcm12216866", "study": "The Role of Extracellular Matrix and Inflammation in the Stratification of Bleeding and Thrombotic Risk of Atrial Fibrillation on Oral Anticoagulant Therapy: Insights from Strat-Af Study", "url": "https://doi.org/10.3390/jcm12216866"}, {"doi": "10.1038/s41405-025-00370-4", "study": "In vitro and in vivo biocompatibility of a porcine cholecystic extracellular matrix (CECM) membrane for tissue regeneration", "url": "https://doi.org/10.1038/s41405-025-00370-4"}, {"doi": "10.1038/s42003-022-03563-x", "study": "Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes", "url": "https://doi.org/10.1038/s42003-022-03563-x"}], "claim": "1 included source were assigned to this outcome class. Directional coding: null=1. Directness coding: indirect=1.", "claim_id": "claim_17"}, {"candidate_sources": [{"doi": "10.3390/cimb47080642", "study": "Harringtonine Attenuates Extracellular Matrix Degradation, Skin Barrier Dysfunction, and Inflammation in an In Vitro Skin Aging Model", "url": "https://doi.org/10.3390/cimb47080642"}, {"doi": "10.1152/function.109.2025", "study": "Repeated application of passive mechanical stress produces selective metabolic and extracellular matrix adaptations in human skeletal muscle but does not prevent disuse-induced atrophy", "url": "https://doi.org/10.1152/function.109.2025"}, {"doi": "10.3390/jcm12216866", "study": "The Role of Extracellular Matrix and Inflammation in the Stratification of Bleeding and Thrombotic Risk of Atrial Fibrillation on Oral Anticoagulant Therapy: Insights from Strat-Af Study", "url": "https://doi.org/10.3390/jcm12216866"}, {"doi": "10.1038/s41405-025-00370-4", "study": "In vitro and in vivo biocompatibility of a porcine cholecystic extracellular matrix (CECM) membrane for tissue regeneration", "url": "https://doi.org/10.1038/s41405-025-00370-4"}, {"doi": "10.1038/s42003-022-03563-x", "study": "Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes", "url": "https://doi.org/10.1038/s42003-022-03563-x"}], "claim": "1 included source were assigned to this outcome class. Directional coding: null=1. Directness coding: mechanistic=1.", "claim_id": "claim_18"}, {"candidate_sources": [{"doi": "10.3390/cimb47080642", "study": "Harringtonine Attenuates Extracellular Matrix Degradation, Skin Barrier Dysfunction, and Inflammation in an In Vitro Skin Aging Model", "url": "https://doi.org/10.3390/cimb47080642"}, {"doi": "10.1152/function.109.2025", "study": "Repeated application of passive mechanical stress produces selective metabolic and extracellular matrix adaptations in human skeletal muscle but does not prevent disuse-induced atrophy", "url": "https://doi.org/10.1152/function.109.2025"}, {"doi": "10.3390/jcm12216866", "study": "The Role of Extracellular Matrix and Inflammation in the Stratification of Bleeding and Thrombotic Risk of Atrial Fibrillation on Oral Anticoagulant Therapy: Insights from Strat-Af Study", "url": "https://doi.org/10.3390/jcm12216866"}, {"doi": "10.1038/s41405-025-00370-4", "study": "In vitro and in vivo biocompatibility of a porcine cholecystic extracellular matrix (CECM) membrane for tissue regeneration", "url": "https://doi.org/10.1038/s41405-025-00370-4"}, {"doi": "10.1038/s42003-022-03563-x", "study": "Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes", "url": "https://doi.org/10.1038/s42003-022-03563-x"}], "claim": "Verification note:** Reference-only or no-abstract records are treated as verification-limited context, not as equal-weight support for the main claim.", "claim_id": "claim_19"}, {"candidate_sources": [{"doi": "10.3390/cimb47080642", "study": "Harringtonine Attenuates Extracellular Matrix Degradation, Skin Barrier Dysfunction, and Inflammation in an In Vitro Skin Aging Model", "url": "https://doi.org/10.3390/cimb47080642"}, {"doi": "10.1152/function.109.2025", "study": "Repeated application of passive mechanical stress produces selective metabolic and extracellular matrix adaptations in human skeletal muscle but does not prevent disuse-induced atrophy", "url": "https://doi.org/10.1152/function.109.2025"}, {"doi": "10.3390/jcm12216866", "study": "The Role of Extracellular Matrix and Inflammation in the Stratification of Bleeding and Thrombotic Risk of Atrial Fibrillation on Oral Anticoagulant Therapy: Insights from Strat-Af Study", "url": "https://doi.org/10.3390/jcm12216866"}, {"doi": "10.1038/s41405-025-00370-4", "study": "In vitro and in vivo biocompatibility of a porcine cholecystic extracellular matrix (CECM) membrane for tissue regeneration", "url": "https://doi.org/10.1038/s41405-025-00370-4"}, {"doi": "10.1038/s42003-022-03563-x", "study": "Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes", "url": "https://doi.org/10.1038/s42003-022-03563-x"}], "claim": "The curated corpus contains no randomized controlled trials and no prospective interventional studies with hard clinical endpoints such as mortality, cardiovascular events, or functional disability. All 59 included studies are either preclinical mechanistic investigations (e.g., Lee 2025, Moudt 2022) or observational cohorts (e.g., Alfano 2023, Ahmadi 2026), meaning the synthesis cannot establish causal directionality for extracellular matrix stiffening in human disease. The absence of randomized evidence precludes any estimate of treatment effect magnitude, and conclusions that depend on associational data must be interpreted with caution given the well-recognized limitations of surrogate endpoints (Ioannidis 2005).", "claim_id": "claim_20"}, {"candidate_sources": [{"doi": "10.3390/cimb47080642", "study": "Harringtonine Attenuates Extracellular Matrix Degradation, Skin Barrier Dysfunction, and Inflammation in an In Vitro Skin Aging Model", "url": "https://doi.org/10.3390/cimb47080642"}, {"doi": "10.1152/function.109.2025", "study": "Repeated application of passive mechanical stress produces selective metabolic and extracellular matrix adaptations in human skeletal muscle but does not prevent disuse-induced atrophy", "url": "https://doi.org/10.1152/function.109.2025"}, {"doi": "10.3390/jcm12216866", "study": "The Role of Extracellular Matrix and Inflammation in the Stratification of Bleeding and Thrombotic Risk of Atrial Fibrillation on Oral Anticoagulant Therapy: Insights from Strat-Af Study", "url": "https://doi.org/10.3390/jcm12216866"}, {"doi": "10.1038/s41405-025-00370-4", "study": "In vitro and in vivo biocompatibility of a porcine cholecystic extracellular matrix (CECM) membrane for tissue regeneration", "url": "https://doi.org/10.1038/s41405-025-00370-4"}, {"doi": "10.1038/s42003-022-03563-x", "study": "Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes", "url": "https://doi.org/10.1038/s42003-022-03563-x"}], "claim": "Single-trial generalization risk is substantial across multiple outcome domains within this corpus. For example, skeletal fracture and bone outcomes are supported by only two observational cohorts — Schurman 2026 and Ahmadi 2026 — alongside one preclinical study (Pereira 2022), while immune mechanistic evidence rests almost entirely on a single in-vitro investigation (Lee 2025). When only one or two studies inform a domain, replication within the corpus is impossible, and apparent consistency may reflect shared methodological biases rather than biological robustness.", "claim_id": "claim_21"}, {"candidate_sources": [{"doi": "10.3390/cimb47080642", "study": "Harringtonine Attenuates Extracellular Matrix Degradation, Skin Barrier Dysfunction, and Inflammation in an In Vitro Skin Aging Model", "url": "https://doi.org/10.3390/cimb47080642"}, {"doi": "10.1152/function.109.2025", "study": "Repeated application of passive mechanical stress produces selective metabolic and extracellular matrix adaptations in human skeletal muscle but does not prevent disuse-induced atrophy", "url": "https://doi.org/10.1152/function.109.2025"}, {"doi": "10.3390/jcm12216866", "study": "The Role of Extracellular Matrix and Inflammation in the Stratification of Bleeding and Thrombotic Risk of Atrial Fibrillation on Oral Anticoagulant Therapy: Insights from Strat-Af Study", "url": "https://doi.org/10.3390/jcm12216866"}, {"doi": "10.1038/s41405-025-00370-4", "study": "In vitro and in vivo biocompatibility of a porcine cholecystic extracellular matrix (CECM) membrane for tissue regeneration", "url": "https://doi.org/10.1038/s41405-025-00370-4"}, {"doi": "10.1038/s42003-022-03563-x", "study": "Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes", "url": "https://doi.org/10.1038/s42003-022-03563-x"}], "claim": "Several clinically relevant endpoints were not measured in any study within the corpus. No study reported gait speed, handgrip strength, or other standard mobility and sarcopenia metrics (Cruz-Jentoft 2019), and no study assessed fall risk or patient-reported quality of life. The mechanistic evidence linking ECM stiffness to immune cell behavior (Lee 2025) and inflammation (Alfano 2023, Hu 2022) has not been translated into clinical outcomes such as infection incidence or inflammatory biomarker trajectories in intervention trials. Similarly, although ECM stiffening has been mechanistically linked to cancer progression (Xie 2025, Wang 2025c) and organ fibrosis (Junior 2023, Sun 2024), this corpus contains no longitudinal studies tracking whether biomechanical ECM changes precede clinical disease onset — leaving the directionality of these associations unresolved.", "claim_id": "claim_22"}, {"candidate_sources": [{"doi": "10.3390/cimb47080642", "study": "Harringtonine Attenuates Extracellular Matrix Degradation, Skin Barrier Dysfunction, and Inflammation in an In Vitro Skin Aging Model", "url": "https://doi.org/10.3390/cimb47080642"}, {"doi": "10.1152/function.109.2025", "study": "Repeated application of passive mechanical stress produces selective metabolic and extracellular matrix adaptations in human skeletal muscle but does not prevent disuse-induced atrophy", "url": "https://doi.org/10.1152/function.109.2025"}, {"doi": "10.3390/jcm12216866", "study": "The Role of Extracellular Matrix and Inflammation in the Stratification of Bleeding and Thrombotic Risk of Atrial Fibrillation on Oral Anticoagulant Therapy: Insights from Strat-Af Study", "url": "https://doi.org/10.3390/jcm12216866"}, {"doi": "10.1038/s41405-025-00370-4", "study": "In vitro and in vivo biocompatibility of a porcine cholecystic extracellular matrix (CECM) membrane for tissue regeneration", "url": "https://doi.org/10.1038/s41405-025-00370-4"}, {"doi": "10.1038/s42003-022-03563-x", "study": "Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes", "url": "https://doi.org/10.1038/s42003-022-03563-x"}], "claim": "For extracellular matrix stiffening, the final interpretation is deliberately tiered: the retained clinical and adjacent evidence profile defines a bounded geroscience rationale, but the corpus does not support treating mechanistic target engagement, intermediate biomarkers, and patient-relevant outcomes as interchangeable evidence. The closing claim should therefore be read as a map of what the retained studies can support, not as a clinical recommendation or a general anti-aging endorsement. Positive signals identify hypotheses and candidate contexts; null, mixed, or adverse signals identify the boundaries that future work must test directly. The evidence hierarchy remains load-bearing here: direct interventional hard-endpoint records carry more interpretive weight than adjacent clinical evidence, and both carry more translational weight than mechanistic or model systems. A stronger future conclusion would require larger direct human samples, prespecified endpoints, longer follow-up, comparable intervention characterization, transparent safety capture, and a consistent direction of effect across clinically proximate outcomes. Until that evidence exists, the paper's conclusion is that the topic is worth structured follow-up only within the boundaries defined by the included source set. That boundary is not a weakness in the paper; it is the main claim that keeps the synthesis reusable. Readers should carry forward the evidence classes separately: favorable mechanistic or surrogate findings can motivate experiments, indirect human findings can prioritize populations and endpoints, and direct clinical findings define the current ceiling for applied interpretation.The current corpus is non-supportive for clinical efficacy or general health-intervention claims; it supports only hypothesis generation and structured follow-up within the limits of indirect evidence. Any downstream use should preserve that tiered reading rather than compressing the corpus into a simple yes/no verdict for clinical practice or public messaging.", "claim_id": "claim_23"}, {"candidate_sources": [{"doi": "10.3390/cimb47080642", "study": "Harringtonine Attenuates Extracellular Matrix Degradation, Skin Barrier Dysfunction, and Inflammation in an In Vitro Skin Aging Model", "url": "https://doi.org/10.3390/cimb47080642"}, {"doi": "10.1152/function.109.2025", "study": "Repeated application of passive mechanical stress produces selective metabolic and extracellular matrix adaptations in human skeletal muscle but does not prevent disuse-induced atrophy", "url": "https://doi.org/10.1152/function.109.2025"}, {"doi": "10.3390/jcm12216866", "study": "The Role of Extracellular Matrix and Inflammation in the Stratification of Bleeding and Thrombotic Risk of Atrial Fibrillation on Oral Anticoagulant Therapy: Insights from Strat-Af Study", "url": "https://doi.org/10.3390/jcm12216866"}, {"doi": "10.1038/s41405-025-00370-4", "study": "In vitro and in vivo biocompatibility of a porcine cholecystic extracellular matrix (CECM) membrane for tissue regeneration", "url": "https://doi.org/10.1038/s41405-025-00370-4"}, {"doi": "10.1038/s42003-022-03563-x", "study": "Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes", "url": "https://doi.org/10.1038/s42003-022-03563-x"}], "claim": "This synthesis maps 59 included sources on Extracellular matrix stiffening across 6 outcome classes and 1051 cross-study disagreements. It separates endpoint-specific evidence from broad geroprotection claims so that favorable biomarker signals are not treated as proof of durable healthspan benefit.", "claim_id": "claim_24"}, {"candidate_sources": [{"doi": "10.3390/cimb47080642", "study": "Harringtonine Attenuates Extracellular Matrix Degradation, Skin Barrier Dysfunction, and Inflammation in an In Vitro Skin Aging Model", "url": "https://doi.org/10.3390/cimb47080642"}, {"doi": "10.1152/function.109.2025", "study": "Repeated application of passive mechanical stress produces selective metabolic and extracellular matrix adaptations in human skeletal muscle but does not prevent disuse-induced atrophy", "url": "https://doi.org/10.1152/function.109.2025"}, {"doi": "10.3390/jcm12216866", "study": "The Role of Extracellular Matrix and Inflammation in the Stratification of Bleeding and Thrombotic Risk of Atrial Fibrillation on Oral Anticoagulant Therapy: Insights from Strat-Af Study", "url": "https://doi.org/10.3390/jcm12216866"}, {"doi": "10.1038/s41405-025-00370-4", "study": "In vitro and in vivo biocompatibility of a porcine cholecystic extracellular matrix (CECM) membrane for tissue regeneration", "url": "https://doi.org/10.1038/s41405-025-00370-4"}, {"doi": "10.1038/s42003-022-03563-x", "study": "Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes", "url": "https://doi.org/10.1038/s42003-022-03563-x"}], "claim": "Across 59 curated reference papers, the evidence base for Extracellular matrix stiffening shows a context-dependent profile. Null findings dominate: contextual other, immune inflammation. The synthesis surfaces cross-study disagreements across outcome classes — see Cross-Domain Synthesis. The Extracellular matrix stiffening anti-aging case as currently constituted is incomplete: mechanistic plausibility coexists with mixed or sparse human-RCT evidence, and the boundary conditions remain to be established.", "claim_id": "claim_25"}, {"candidate_sources": [{"doi": "10.3390/cimb47080642", "study": "Harringtonine Attenuates Extracellular Matrix Degradation, Skin Barrier Dysfunction, and Inflammation in an In Vitro Skin Aging Model", "url": "https://doi.org/10.3390/cimb47080642"}, {"doi": "10.1152/function.109.2025", "study": "Repeated application of passive mechanical stress produces selective metabolic and extracellular matrix adaptations in human skeletal muscle but does not prevent disuse-induced atrophy", "url": "https://doi.org/10.1152/function.109.2025"}, {"doi": "10.3390/jcm12216866", "study": "The Role of Extracellular Matrix and Inflammation in the Stratification of Bleeding and Thrombotic Risk of Atrial Fibrillation on Oral Anticoagulant Therapy: Insights from Strat-Af Study", "url": "https://doi.org/10.3390/jcm12216866"}, {"doi": "10.1038/s41405-025-00370-4", "study": "In vitro and in vivo biocompatibility of a porcine cholecystic extracellular matrix (CECM) membrane for tissue regeneration", "url": "https://doi.org/10.1038/s41405-025-00370-4"}, {"doi": "10.1038/s42003-022-03563-x", "study": "Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes", "url": "https://doi.org/10.1038/s42003-022-03563-x"}], "claim": "The strongest unresolved contrast is the agreement between Zhu 2023 and Zhang 2023b on contextual adjacent evidence (severity 1/5), which defines the boundary condition future studies must test rather than smooth over.", "claim_id": "claim_26"}, {"candidate_sources": [{"doi": "10.3390/cimb47080642", "study": "Harringtonine Attenuates Extracellular Matrix Degradation, Skin Barrier Dysfunction, and Inflammation in an In Vitro Skin Aging Model", "url": "https://doi.org/10.3390/cimb47080642"}, {"doi": "10.1152/function.109.2025", "study": "Repeated application of passive mechanical stress produces selective metabolic and extracellular matrix adaptations in human skeletal muscle but does not prevent disuse-induced atrophy", "url": "https://doi.org/10.1152/function.109.2025"}, {"doi": "10.3390/jcm12216866", "study": "The Role of Extracellular Matrix and Inflammation in the Stratification of Bleeding and Thrombotic Risk of Atrial Fibrillation on Oral Anticoagulant Therapy: Insights from Strat-Af Study", "url": "https://doi.org/10.3390/jcm12216866"}, {"doi": "10.1038/s41405-025-00370-4", "study": "In vitro and in vivo biocompatibility of a porcine cholecystic extracellular matrix (CECM) membrane for tissue regeneration", "url": "https://doi.org/10.1038/s41405-025-00370-4"}, {"doi": "10.1038/s42003-022-03563-x", "study": "Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes", "url": "https://doi.org/10.1038/s42003-022-03563-x"}], "claim": "This synthesis adds a design-level evidence-weighting layer and an explicit cross-study disagreement map, keeping boundary conditions visible instead of averaging them away in narrative summary.", "claim_id": "claim_27"}, {"candidate_sources": [{"doi": "10.3390/cimb47080642", "study": "Harringtonine Attenuates Extracellular Matrix Degradation, Skin Barrier Dysfunction, and Inflammation in an In Vitro Skin Aging Model", "url": "https://doi.org/10.3390/cimb47080642"}, {"doi": "10.1152/function.109.2025", "study": "Repeated application of passive mechanical stress produces selective metabolic and extracellular matrix adaptations in human skeletal muscle but does not prevent disuse-induced atrophy", "url": "https://doi.org/10.1152/function.109.2025"}, {"doi": "10.3390/jcm12216866", "study": "The Role of Extracellular Matrix and Inflammation in the Stratification of Bleeding and Thrombotic Risk of Atrial Fibrillation on Oral Anticoagulant Therapy: Insights from Strat-Af Study", "url": "https://doi.org/10.3390/jcm12216866"}, {"doi": "10.1038/s41405-025-00370-4", "study": "In vitro and in vivo biocompatibility of a porcine cholecystic extracellular matrix (CECM) membrane for tissue regeneration", "url": "https://doi.org/10.1038/s41405-025-00370-4"}, {"doi": "10.1038/s42003-022-03563-x", "study": "Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes", "url": "https://doi.org/10.1038/s42003-022-03563-x"}], "claim": "| Evidence domain | Direct sources | Indirect / mechanism sources | Direction profile | Interpretation boundary |", "claim_id": "claim_28"}, {"candidate_sources": [{"doi": "10.3390/cimb47080642", "study": "Harringtonine Attenuates Extracellular Matrix Degradation, Skin Barrier Dysfunction, and Inflammation in an In Vitro Skin Aging Model", "url": "https://doi.org/10.3390/cimb47080642"}, {"doi": "10.1152/function.109.2025", "study": "Repeated application of passive mechanical stress produces selective metabolic and extracellular matrix adaptations in human skeletal muscle but does not prevent disuse-induced atrophy", "url": "https://doi.org/10.1152/function.109.2025"}, {"doi": "10.3390/jcm12216866", "study": "The Role of Extracellular Matrix and Inflammation in the Stratification of Bleeding and Thrombotic Risk of Atrial Fibrillation on Oral Anticoagulant Therapy: Insights from Strat-Af Study", "url": "https://doi.org/10.3390/jcm12216866"}, {"doi": "10.1038/s41405-025-00370-4", "study": "In vitro and in vivo biocompatibility of a porcine cholecystic extracellular matrix (CECM) membrane for tissue regeneration", "url": "https://doi.org/10.1038/s41405-025-00370-4"}, {"doi": "10.1038/s42003-022-03563-x", "study": "Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes", "url": "https://doi.org/10.1038/s42003-022-03563-x"}], "claim": "| contextual adjacent evidence | 0 | 46 | null | direct interventional hard-endpoint gap |", "claim_id": "claim_29"}, {"candidate_sources": [{"doi": "10.3390/cimb47080642", "study": "Harringtonine Attenuates Extracellular Matrix Degradation, Skin Barrier Dysfunction, and Inflammation in an In Vitro Skin Aging Model", "url": "https://doi.org/10.3390/cimb47080642"}, {"doi": "10.1152/function.109.2025", "study": "Repeated application of passive mechanical stress produces selective metabolic and extracellular matrix adaptations in human skeletal muscle but does not prevent disuse-induced atrophy", "url": "https://doi.org/10.1152/function.109.2025"}, {"doi": "10.3390/jcm12216866", "study": "The Role of Extracellular Matrix and Inflammation in the Stratification of Bleeding and Thrombotic Risk of Atrial Fibrillation on Oral Anticoagulant Therapy: Insights from Strat-Af Study", "url": "https://doi.org/10.3390/jcm12216866"}, {"doi": "10.1038/s41405-025-00370-4", "study": "In vitro and in vivo biocompatibility of a porcine cholecystic extracellular matrix (CECM) membrane for tissue regeneration", "url": "https://doi.org/10.1038/s41405-025-00370-4"}, {"doi": "10.1038/s42003-022-03563-x", "study": "Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes", "url": "https://doi.org/10.1038/s42003-022-03563-x"}], "claim": "| immune and inflammation | 0 | 5 | null | direct interventional hard-endpoint gap |", "claim_id": "claim_30"}]}

metadata

{
  "researka_object_type": "publication_sidecar",
  "researka_publication_id": "79d2cfdb-60fe-4786-be4f-b55cacadc266",
  "researka_submission_id": "ca33ca55-467b-41c9-b22d-473853ddf6df",
  "sidecar_name": "citation_traces.json",
  "sidecar_url": "https://api.researka.org/publications/79d2cfdb-60fe-4786-be4f-b55cacadc266/sidecars/citation_traces.json"
}

view full chain →