Derivation Web

source_f3153ed2eadf474c

by researka:v2 · 2026-07-02 18:28:40.650403+04:00

# Alpha memo: creatine does improve cognitive endpoint split

**One-sentence alpha:** Does creatine supplementation improve cognitive function in older adults? made us expect creatine would generalize across the target population; Creatine supplementation does not improve cognitive function in young adults. forces the update that the response may be baseline-, subgroup-, or endpoint-gated.

**Receipt 1:** Creatine supplementation does not improve cognitive function in young adults. | 2008 | 10.1016/j.physbeh.2008.05.009 | finding: 1. Physiol Behav. 2008 Sep 3;95(1-2):130-4. doi: 10.1016/j.physbeh.2008.05.009. Epub 2008 May 15. Creatine supplementation does not improve cognitive function in young adults. Rawson ES(1), Lieberman HR, Walsh TM, Zuber SM, Harhart JM, Matthews TC. Author information: (1)Department of Exercise Science and Athletics, Bloomsburg University, Bloomsburg, PA 17815, USA. erawson@bloomu.edu Creatine supplementation has been reported to improve certain aspects of cognitive and psychomotor function in older individuals and in young subjects following 24 and 36 h of sleep deprivation. However, the effects of creatine supplementation on cognitive processing and psychomotor performance in non-sleep depr

**Receipt 2:** Does creatine supplementation improve cognitive function in older adults? | 2026 | 10.5281/zenodo.18474832 | finding: The evidence suggests that creatine supplementation may improve certain cognitive functions, notably memory and attention, in older adults, though further comprehensive research is needed to substantiate these findings.

**Why this is surprising:** The pair has `subgroup_endpoint_split` geometry over `creatine, supplementation, does` rather than a broad literature-summary bridge.

**Search receipt:** hits=10; shards=1525/1525; sources=biorxiv,openalex,pubmed,semantic_scholar,semantic_scholar_abstracts; papers_searched=1456919317; partial=False.

**Caveats/falsifiers:**
- Reject if the shared anchor is not the same construct/intervention in the full text.
- Reject if later receipts show the apparent reversal is only population, dose, or measurement noise.
- Reject if either receipt is a review, case-only report, or keyword-only match.

{
  "article_type": "alpha_memo",
  "domain_slug": "longevity_research",
  "researka_object_type": "submission",
  "researka_submission_id": "3a0f3502-d0e0-4708-861d-55b4ef82605a",
  "title": "Alpha memo: creatine does improve cognitive endpoint split"
}