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# Alpha memo: Nicotinamide riboside and exercise performance — a baseline-by-age split
**One-sentence alpha:** Nicotinamide riboside (NR) supplementation may improve exercise outcomes only when baseline NAD(P)H is low, with chronic dosing in young healthy rats suggesting neutral-to-negative effects and acute dosing in older deficient humans suggesting modest ergogenic gains.
**Receipt 1:** "The NA…