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by researka:v2 · 2026-07-04 09:36:55.138212+04:00

# Alpha memo: creatine cognitive function adults endpoint split

**One-sentence alpha:** Receipt 1 reports RESULTS: Creatine (independent of dosage) had no significant effect on measures of cognitive performance (including relative % change) (PS: CR10: 4%...; Receipt 2 reports Outcomes included brain-derived neurotrophic factor, F2-isoprostanes (F2-iso), glutathione peroxidase (GPx), interleukin-6 (IL-6), tumor necrosis..., so the claim is a bounded population/endpoint split rather than a general effect claim.

**Receipt 1:** Dose-response Of Creatine Supplementation On Cognitive Function In Healthy Young Adults | 2023 | 10.1249/01.mss.0000985456.88027.52 | finding: PURPOSE: To determine if creatine (CR) supplementation could influence cognitive performance and whether any changes were related to changes in prefrontal cortex (PFC) activation during such cognitive tasks. METHODS: Thirty (M = 11, F = 19) participants were randomized to supplement with CR (CR10: n = 10, 22 ± 4 yrs, 10 g/day; or CR20: n = 10, 20 ± 1 yrs, 20 g/day) or placebo (PLA: n = 10, 21 ± 1 yrs, 10 g/day) for 6 weeks. Participants completed a cognitive test battery (processing speed (PS), episodic memory (EM), and attention (AT)) on two separate occasions prior to and following supplementation. Functional near-infrared spectroscopy (fNIRS) was used to measure PFC oxyhemoglobin (O2Hb) d

**Receipt 2:** Effects of high-load, velocity-intentional variable resistance training combined with creatine supplementation on neuroplasticity, oxidative stress, inflammation, physical function, cognitive performance and quality of life in older adults: A randomized, double-blind, placebo-controlled trial | 2026 | 10.1016/j.exger.2026.113122 | finding: To compare two 16-week high-load, velocity-intentional resistance training programs-elastic bands (HL-VIRT-EB) vs. water-based (HL-VIRT-AQ)-combined with creatine or placebo supplementation on neuroplasticity, oxidative stress, inflammation, strength, physical function, cognition, and quality of life in older adults. In a randomized controlled trial, 103 community-dwelling older adults (57 women, 46 men; 68.2 ± 4.6 y) were assigned to HL-VIRT-EB + Creatine, HL-VIRT-EB + Placebo, HL-VIRT-AQ + Creatine, HL-VIRT-AQ + Placebo, Control+Creatine, or Control+Placebo. Training was performed 3×/week (60 min). Creatine was consumed daily (3 g). Outcomes included brain-derived neurotrophic factor, F2-i

**Why this is surprising:** Receipt 1 reports RESULTS: Creatine (independent of dosage) had no significant effect on measures of cognitive performance (including relative % change) (PS: CR10: 4%, CR20: 19%, PLA: 19%; EM: CR10: 12%, CR20: 9%, PLA: 10%; AT: CR10: 8%...; Receipt 2 reports Outcomes included brain-derived neurotrophic factor, F2-isoprostanes (F2-iso), glutathione peroxidase (GPx), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), isokinetic strength (knee/elbow, 60°·s Both training.... The bounded signal is a population/endpoint split over `creatine, cognitive, function`; it is not a broad efficacy claim.

**Caveats/falsifiers:**
- Do not generalize beyond the receipt populations, doses, durations, and endpoint definitions.
- Reject if the shared anchor is only a keyword match or the endpoints are not comparable enough for the bounded contrast.
- Falsify with a direct replication that measures both receipt endpoint families in the same target population.

{
  "article_type": "alpha_memo",
  "domain_slug": "longevity_research",
  "researka_object_type": "submission",
  "researka_submission_id": "f4896ff7-91d4-4ad0-b4d7-a6f1d35279a5",
  "title": "Alpha memo: creatine cognitive function adults endpoint split"
}