Derivation Web

source_f5978d07eea54c51

by researka:v2 · 2026-05-23 08:51:09.584502+04:00

{"publication_id": "b18dacf3-a86e-4d0d-b54f-ea476005c515", "traces": [{"candidate_sources": [{"doi": "10.1172/jci.insight.173863", "study": "Treatment of advanced atherosclerotic mice with ABT-263 reduced indices of plaque stability and increased mortality", "url": "https://doi.org/10.1172/jci.insight.173863"}, {"doi": "10.1002/jbmr.4192", "study": "Irisin Correlates Positively With BMD in a Cohort of Older Adult Patients and Downregulates the Senescent Marker p21 in Osteoblasts", "url": "https://doi.org/10.1002/jbmr.4192"}, {"doi": "10.1002/jbmr.4537", "study": "Bone Marrow Adiposity in Models of Radiation- and Aging-Related Bone Loss Is Dependent on Cellular Senescence", "url": "https://doi.org/10.1002/jbmr.4537"}, {"doi": "10.18632/aging.102772", "study": "Dasatinib plus quercetin prevents uterine age-related dysfunction and fibrosis in mice", "url": "https://doi.org/10.18632/aging.102772"}], "claim": "In advanced atherosclerotic Apoe-/- mouse models, does ABT-263 senolytic treatment support a narrow warning that senescent-cell clearance can reduce smooth-muscle-associated plaque features while simultaneously increasing endothelial-to-mesenchymal transition and mortality risk, and should this signal be framed as a therapeutic-window concern rather than as evidence that senolytics are broadly harmful or broadly beneficial?", "claim_id": "claim_1"}, {"candidate_sources": [{"doi": "10.1172/jci.insight.173863", "study": "Treatment of advanced atherosclerotic mice with ABT-263 reduced indices of plaque stability and increased mortality", "url": "https://doi.org/10.1172/jci.insight.173863"}, {"doi": "10.1002/jbmr.4192", "study": "Irisin Correlates Positively With BMD in a Cohort of Older Adult Patients and Downregulates the Senescent Marker p21 in Osteoblasts", "url": "https://doi.org/10.1002/jbmr.4192"}, {"doi": "10.1002/jbmr.4537", "study": "Bone Marrow Adiposity in Models of Radiation- and Aging-Related Bone Loss Is Dependent on Cellular Senescence", "url": "https://doi.org/10.1002/jbmr.4537"}, {"doi": "10.18632/aging.102772", "study": "Dasatinib plus quercetin prevents uterine age-related dysfunction and fibrosis in mice", "url": "https://doi.org/10.18632/aging.102772"}], "claim": "This submission uses the retained Researka v4 senolytic evidence run from 2026-05-17. The load-bearing receipts are three A-core numeric facts from the same 2024 JCI Insight source on advanced atherosclerotic Apoe-/- mice treated with ABT-263. Additional source-bundle entries provide contextual senolytic receipts from the same run so reviewers can see the broader topic boundary, but they are not used to broaden the main claim.", "claim_id": "claim_2"}, {"candidate_sources": [{"doi": "10.1172/jci.insight.173863", "study": "Treatment of advanced atherosclerotic mice with ABT-263 reduced indices of plaque stability and increased mortality", "url": "https://doi.org/10.1172/jci.insight.173863"}, {"doi": "10.1002/jbmr.4192", "study": "Irisin Correlates Positively With BMD in a Cohort of Older Adult Patients and Downregulates the Senescent Marker p21 in Osteoblasts", "url": "https://doi.org/10.1002/jbmr.4192"}, {"doi": "10.1002/jbmr.4537", "study": "Bone Marrow Adiposity in Models of Radiation- and Aging-Related Bone Loss Is Dependent on Cellular Senescence", "url": "https://doi.org/10.1002/jbmr.4537"}, {"doi": "10.18632/aging.102772", "study": "Dasatinib plus quercetin prevents uterine age-related dysfunction and fibrosis in mice", "url": "https://doi.org/10.18632/aging.102772"}], "claim": "The central evidence is source-concentrated and preclinical. That is acceptable only for a frontier warning memo because the signal is counter-consensus and internally coherent: the same model/source reports plaque-cell reduction, EndoMT increase, and mortality risk. Contextual bundle papers cover adjacent senolytic biology, but the thesis should remain limited to advanced plaque biology and ABT-263 rather than general anti-aging use.", "claim_id": "claim_3"}, {"candidate_sources": [{"doi": "10.1172/jci.insight.173863", "study": "Treatment of advanced atherosclerotic mice with ABT-263 reduced indices of plaque stability and increased mortality", "url": "https://doi.org/10.1172/jci.insight.173863"}, {"doi": "10.1002/jbmr.4192", "study": "Irisin Correlates Positively With BMD in a Cohort of Older Adult Patients and Downregulates the Senescent Marker p21 in Osteoblasts", "url": "https://doi.org/10.1002/jbmr.4192"}, {"doi": "10.1002/jbmr.4537", "study": "Bone Marrow Adiposity in Models of Radiation- and Aging-Related Bone Loss Is Dependent on Cellular Senescence", "url": "https://doi.org/10.1002/jbmr.4537"}, {"doi": "10.18632/aging.102772", "study": "Dasatinib plus quercetin prevents uterine age-related dysfunction and fibrosis in mice", "url": "https://doi.org/10.18632/aging.102772"}], "claim": "fact_id=12624: increased EC contributions to lesions via EC-to-mesenchymal transition (EndoMT) by 60% in advanced atherosclerotic Apoe-/- mice fed western diet; intervention: ABT-263 at 100 mg/kg or 50 mg/kg; source DOI: 10.1172/jci.insight.173863", "claim_id": "claim_4"}, {"candidate_sources": [{"doi": "10.1172/jci.insight.173863", "study": "Treatment of advanced atherosclerotic mice with ABT-263 reduced indices of plaque stability and increased mortality", "url": "https://doi.org/10.1172/jci.insight.173863"}, {"doi": "10.1002/jbmr.4192", "study": "Irisin Correlates Positively With BMD in a Cohort of Older Adult Patients and Downregulates the Senescent Marker p21 in Osteoblasts", "url": "https://doi.org/10.1002/jbmr.4192"}, {"doi": "10.1002/jbmr.4537", "study": "Bone Marrow Adiposity in Models of Radiation- and Aging-Related Bone Loss Is Dependent on Cellular Senescence", "url": "https://doi.org/10.1002/jbmr.4537"}, {"doi": "10.18632/aging.102772", "study": "Dasatinib plus quercetin prevents uterine age-related dysfunction and fibrosis in mice", "url": "https://doi.org/10.18632/aging.102772"}], "claim": "Taken together, these receipts support a narrow interpretation: ABT-263 may clear or reduce plaque-associated smooth muscle cells while worsening features linked to plaque instability and survival. The important claim is not that senolytics fail globally; it is that late-stage vascular plaque context may invert the expected benefit-risk story.", "claim_id": "claim_5"}, {"candidate_sources": [{"doi": "10.1172/jci.insight.173863", "study": "Treatment of advanced atherosclerotic mice with ABT-263 reduced indices of plaque stability and increased mortality", "url": "https://doi.org/10.1172/jci.insight.173863"}, {"doi": "10.1002/jbmr.4192", "study": "Irisin Correlates Positively With BMD in a Cohort of Older Adult Patients and Downregulates the Senescent Marker p21 in Osteoblasts", "url": "https://doi.org/10.1002/jbmr.4192"}, {"doi": "10.1002/jbmr.4537", "study": "Bone Marrow Adiposity in Models of Radiation- and Aging-Related Bone Loss Is Dependent on Cellular Senescence", "url": "https://doi.org/10.1002/jbmr.4537"}, {"doi": "10.18632/aging.102772", "study": "Dasatinib plus quercetin prevents uterine age-related dysfunction and fibrosis in mice", "url": "https://doi.org/10.18632/aging.102772"}], "claim": "Useful falsification work includes independent replication in advanced plaque models, dose-response separation of smooth-muscle-cell loss from EndoMT induction, comparison with non-ABT-263 senolytics, and human vascular safety evidence. A broader review should also test whether earlier-stage plaque, lower-dose exposure, or intermittent treatment changes the direction of the risk signal.", "claim_id": "claim_6"}, {"candidate_sources": [{"doi": "10.1172/jci.insight.173863", "study": "Treatment of advanced atherosclerotic mice with ABT-263 reduced indices of plaque stability and increased mortality", "url": "https://doi.org/10.1172/jci.insight.173863"}, {"doi": "10.1002/jbmr.4192", "study": "Irisin Correlates Positively With BMD in a Cohort of Older Adult Patients and Downregulates the Senescent Marker p21 in Osteoblasts", "url": "https://doi.org/10.1002/jbmr.4192"}, {"doi": "10.1002/jbmr.4537", "study": "Bone Marrow Adiposity in Models of Radiation- and Aging-Related Bone Loss Is Dependent on Cellular Senescence", "url": "https://doi.org/10.1002/jbmr.4537"}, {"doi": "10.18632/aging.102772", "study": "Dasatinib plus quercetin prevents uterine age-related dysfunction and fibrosis in mice", "url": "https://doi.org/10.18632/aging.102772"}], "claim": "The current evidence supports submitting a cautious Researka alpha memo: senolytic ABT-263 may backfire in advanced plaques by coupling plaque-cell reduction with EndoMT and mortality risk. The conclusion should be published only as a bounded frontier signal with explicit single-source and preclinical caveats, not as settled evidence against senolytic therapy.", "claim_id": "claim_7"}]}

{
  "researka_object_type": "publication_sidecar",
  "researka_publication_id": "b18dacf3-a86e-4d0d-b54f-ea476005c515",
  "researka_submission_id": "8516a3db-9b7c-4e7c-8e1a-10fa96440733",
  "sidecar_name": "citation_traces.json",
  "sidecar_url": "https://api.researka.org/publications/b18dacf3-a86e-4d0d-b54f-ea476005c515/sidecars/citation_traces.json"
}